Greenville, North Carolina Clinical Trials

A listing of Greenville, North Carolina clinical trials actively recruiting patient volunteers.

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Found 83 clinical trials
Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH)

Combination therapy in pulmonary arterial hypertension (PAH) has been the subject of active investigation for more than a decade, with the benefit of targeting different pathways known to be involved in the pathogenesis of the disease. Adherence to prescribed therapy has an impact on clinical outcomes. Reducing the pill/tablet count …

Pitt County Memorial Hospital d/b/a Vidant Medical Center
 (2.3 away) Contact site
  • 100 views
  • 17 Jul, 2021
  • +219 other locations
Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer

This study is being done to see how well two drugs (enfortumab vedotin and pembrolizumab) work together to treat patients with urothelial cancer. The study will compare these drugs to other drugs that are usually used to treat this cancer (standard of care). The patients in this study will have …

systemic therapy
adjuvant chemotherapy
carcinoma
metastatic urothelial carcinoma
transitional cell carcinoma
Vidant Medical Center
 (2.7 away) Contact site
  • 5 views
  • 21 Jul, 2021
  • +111 other locations
Efficacy and Safety APT-1011 in Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)

This is a 2-part randomized, double-blind, placebo-controlled study of APT-1011 in adults and adolescents (12 years) with EoE. Part A will evaluate the efficacy and safety of APT-1011 3 mg administered HS for the induction of response to treatment (histologic and symptomatic) over 12 weeks. Part B will evaluate histological …

esophagogastroduodenoscopy
dysphagia
Carolina Research
 (2.7 away) Contact site
  • 93 views
  • 19 Jul, 2021
  • +141 other locations
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge

East Carolina University/Vidant Health
 (5.0 away) Contact site
  • 0 views
  • 21 Jul, 2021
  • +74 other locations
Effect of Sodium Zirconium Cyclosilicate on Arrythmia-related Cardiovascular Outcomes in Participants on Chronic Hemodialysis With Recurrent Hyperkalemia (DIALIZE-Outcomes)

The purpose of this study is to evaluate the effect of Sodium Zirconium Cyclosilicate (SZC) on arrhythmia-related cardiovascular outcomes in participants on chronic hemodialysis with recurrent hyperkalemia.

Research Site
 (2.7 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +252 other locations
Rofecoxib Efficacy and Safety Evaluation Trial in Hemophilic Arthropathy

This is a multicenter, randomized, double-blind study to evaluate the efficacy and safety of TRM-201 (rofecoxib) versus Placebo in the treatment of patients with hemophilic arthropathy (HA) over a 12-week period (Part I) that is followed by a year-long (52 week) open-label extension (Part II) to further evaluate the safety …

East Carolina University
 (2.5 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • +49 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

metastatic colorectal cancer
fluorouracil
cancer treatment
major surgery
rifampin
East Carolina University
 (2.7 away) Contact site
  • 65 views
  • 27 Jul, 2021
  • +978 other locations
Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects 1 Month to <17 Years Undergoing MRI Scans

This is a randomized, double-blind, dose-ranging study of the efficacy and safety of dexmedetomidine (DEX) when used with propofol as needed, for procedural sedation of pediatric subjects 1 month to <17 years of age undergoing MRI scans in the US and Japan.

Brody School of Medicine at East Carolina University
 (2.7 away) Contact site
  • 5 views
  • 26 Jul, 2021
  • +37 other locations
A Study of PRN1008 in Adult Patients With Immune Thrombocytopenia (ITP)

This is a 2 part (Part A and B) adaptive, open-label, dose-finding study of PRN1008 in patients with ITP who are refractory or relapsed with no available and approved therapeutic options, with a platelet count <30,000/L on two counts no sooner than 7 days apart in the 15 days before …

thrombocytopenia
autoimmune thrombocytopenia
platelet count
Central Recruiting (Principia Biopharma)
 (2.7 away) Contact site
  • 450 views
  • 23 Jul, 2021
  • +63 other locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

leucovorin
immunosuppressive
absolute neutrophil count
fluorouracil
adenocarcinoma
East Carolina University
 (2.7 away) Contact site
  • 1047 views
  • 29 Jul, 2021
  • +589 other locations