Durham, North Carolina Clinical Trials

A listing of Durham, North Carolina clinical trials actively recruiting patient volunteers.

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Found 254 clinical trials
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Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation (KRYSTAL-7)

This Phase 2 study evaluates the clinical activity and safety of MRTX849 in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS.

KRAS
pembrolizumab
Duke University Medical Center
 (2.5 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • +40 other locations
A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy Compared With Carboplatin-Pemetrexed in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

The purpose of this study is to compare the efficacy, as demonstrated by progression-free survival (PFS), in participants treated with amivantamab in combination with chemotherapy, versus chemotherapy alone in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) characterized by EGFR Exon 20ins mutations.

carboplatin
measurable disease
cancer chemotherapy
growth factor
pemetrexed
Durham VAMC
 (3.3 away) Contact site
  • 0 views
  • 29 Jul, 2021
  • +281 other locations
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus prednisone in participants with deleterious germline or somatic Homologous Recombination Repair (HRR) gene-mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) provides superior efficacy in improving radiographic progression-free survival (rPFS).

Durham VAMC
 (3.3 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +397 other locations
Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients

The purpose of this study is to determine whether PXT3003 is effective and safe in the treatment of Charcot-Marie-Tooth disease - Type 1A. This double-blind study will assess in parallel groups 1 dose of PXT3003 compared to Placebo in CMT1A patients treated for 15 months.

UNC Department of Neurology Peripheral Neuropathy Center
 (8.6 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +47 other locations
ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo …

Duke University Hospital (Site 301-006), 2301 Erwin Road
 (2.4 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +38 other locations
ACTIV-6: COVID-19 Study of Repurposed Medications

The purpose of this study is to evaluate the effectiveness of repurposed medications (study drug(s) in reducing symptoms of non-hospitalized participants with mild to moderate COVID-19. Participants will receive either study drug or placebo. They will self-report any new or worsening symptoms or medical events they may experience while taking …

Duke Clinical Research Institute
 (4.3 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +3 other locations
A Study to Evaluate DAY101 in Pediatric and Young Adult Patients With Relapsed or Progressive Low-Grade Glioma

FIREFLY-1 is a Phase 2, multi center, open-label study to evaluate the safety and efficacy of oral pan-RAF inhibitor DAY101 in pediatric, adolescent, and young adult patients with recurrent or progressive low-grade glioma harboring a known BRAF alteration.

Duke Univ. Medical Center
 (4.3 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +12 other locations
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge

Duke Medical Center
 (3.3 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +74 other locations
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix

This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters.

Duke University
 (4.3 away) Contact site
  • 219 views
  • 26 Jul, 2021
  • +13 other locations
A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura

The main aim of the study is to check for side effects of TAK-755. Participants will either receive TAK-755 every week or every other week to prevent bleeds (prophylactic arm) or they will receive TAK-755 to treat an acute bleed (on-demand arm). Participants in the prophylactic arm will receive treatment …

Duke University Medical Center
 (4.3 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +21 other locations