Cornelius, North Carolina Clinical Trials

A listing of Cornelius, North Carolina clinical trials actively recruiting patient volunteers.

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Found 88 clinical trials
Pivotal Randomized Open-label Study of Optune (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM

To test the effectiveness and safety of Optune given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patients, compared to radiation therapy and temozolomide alone. In both arms, Optune and maintenance temozolomide are continued following radiation therapy.

complete resection
gross total resection
cancer
MRI
temozolomide
Novant Health Medical Center Huntersville
 (3.9 away) Contact site
  • 25 views
  • 02 Sep, 2021
  • +161 other locations
Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study

The purpose of study JZP110-405 is to determine whether solriamfetol is effective at improving cognitive function in participants with excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA).

Advanced Respiratory and Sleep Medicine, PLLC
 (4.6 away) Contact site
  • 0 views
  • 25 Sep, 2021
  • +14 other locations
Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid Tumors

Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-Small Cell Lung Cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study is to evaluate the safety and efficacy …

platinum-based chemotherapy
epidermal growth factor
osimertinib
cancer chemotherapy
targeted therapy
Carolina BioOncology Institute /ID# 225358
 (4.6 away) Contact site
  • 0 views
  • 08 Aug, 2021
  • +29 other locations
A Study of GSK3511294 (Depemokimab) in Participants With Severe Asthma With an Eosinophilic Phenotype

This study will assess the efficacy and safety of GSK3511294 (Depemokimab) as an adjunctive therapy in participants with severe uncontrolled asthma with an eosinophilic phenotype despite standard of care (SoC) treatment with medium to high dose inhaled corticosteroid (ICS) plus at least one additional controller.

GSK Investigational Site
 (5.0 away) Contact site
  • 0 views
  • 17 Sep, 2021
  • +54 other locations
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (LOGOS)

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.

Research Site
 (5.0 away) Contact site
  • 7 views
  • 21 Jul, 2021
  • +227 other locations
Study to Evaluate Adverse Events and Change in Disease Activity in Adult and Adolescent Participants With Acute Hepatitis C Virus (HCV) Infection on Treatment With Oral Tablets of Glecaprevir (GLE)/Pibrentasvir (PIB)

Hepatitis C Virus (HCV) infection is a global health problem. HCV mainly affects liver cells and causes the liver to become inflamed and damaged. This study will evaluate how safe and effective glecaprevir/pibrentasvir (GLE/PIB) is in adult and adolescent participants with acute HCV infection. GLE/PIB is an approved drug for …

Atrium Health - Huntersville /ID# 238365
 (4.6 away) Contact site
  • 0 views
  • 26 Sep, 2021
  • +56 other locations
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer The PDIGREE Study

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

carcinoma
calcium
metastatic renal cell carcinoma
pd-l1
karnofsky performance status
Novant Health Presbyterian Medical Center Huntersville
 (5.0 away) Contact site
  • 157 views
  • 27 Sep, 2021
  • +688 other locations
CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

This is a Phase 1/1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in …

breast cancer
colorectal neoplasm
bladder cancer
triple negative breast cancer
sarcoma
Carolina BioOncology Institute
 (4.6 away) Contact site
  • 1241 views
  • 05 Aug, 2021
  • +26 other locations
A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies

This is a Phase 1, multicenter, open-label, dose-escalation study to evaluate the safety, tolerability, PK, PD, and clinical activity of domvanalimab (AB154) as monotherapy and in combination with zimberelimab (AB122) in participants with advanced solid malignancies.

hepatitis
monoclonal antibodies
cancer chemotherapy
cancer
growth factor
Carolina BioOncology Institute
 (4.6 away) Contact site
  • 160 views
  • 02 Aug, 2021
  • +20 other locations
Testing the Combination of Olaparib and Durvalumab Cediranib and Durvalumab Olaparib and Capivasertib and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone and Olaparib Alone

This phase II trial studies the effects of the combination of olaparib and durvalumab, cediranib and durvalumab, olaparib and capivasertib, and cediranib alone in treating patients with endometrial cancer that has come back (recurrent) or does not respond to treatment (refractory). Olaparib, cediranib, and capivasertib may stop the growth of …

carcinoma
adenocarcinoma
ct scan
serous adenocarcinoma
progesterone
Novant Health Presbyterian Medical Center Huntersville
 (5.0 away) Contact site
  • 81 views
  • 26 Sep, 2021
  • +504 other locations