Cornelius, North Carolina Clinical Trials

A listing of Cornelius, North Carolina clinical trials actively recruiting patient volunteers.

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Found 88 clinical trials
MGC018 With or Without MGA012 in Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of MGC018 administered alone and in combination with MGA012 in patients with advanced solid tumors.

measurable disease
pd-l1
cancer
hormone therapy
solid tumour
Carolina Biooncology Institute
 (5.0 away) Contact site
  • 12 views
  • 31 Aug, 2021
  • +17 other locations
A Study to Determine the Safety Tolerability Pharmacokinetics and Preliminary Efficacy of ABBV-927 With ABBV-368 Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or chemotherapy in participants with selected solid tumors. This study consists of 2 main parts, a dose-escalation phase and a dose-expansion phase. The dose-expansion phase can begin once the recommended phase 2 dose/maximum …

immunohistochemistry
epidermal growth factor receptor
estrogen
growth factor
advanced malignant solid tumor
Carolina BioOncology Institute /ID# 210664
 (5.0 away) Contact site
  • 52 views
  • 01 Aug, 2021
  • +37 other locations
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer The PDIGREE Study

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

measurable disease
cancer
pembrolizumab
tremelimumab
il-2
Novant Health Presbyterian Medical Center Huntersville
 (5.0 away) Contact site
  • 157 views
  • 27 Sep, 2021
  • +688 other locations
Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab

This clinical trial is a Phase 1/2, open-label, sequential-group, dose-escalation and cohort expansion study to determine the safety and preliminary anti-tumor activity of FLX475 as monotherapy and in combination with pembrolizumab. The study will be conducted in 2 parts, a dose-escalation phase (Part 1) and a cohort expansion phase (Part …

carcinoma
metastasis
gastric cancer
squamous cell carcinoma
lung cancer
Carolina BioOncology Institute
 (5.0 away) Contact site
  • 50 views
  • 05 Jul, 2021
  • +30 other locations
Durvalumab Long-Term Safety and Efficacy Study

The aims of the study are to monitor the long-term safety of durvalumab, to provide continued treatment or retreatment with durvalumab to eligible patients, and to collect overall survival (OS) information.

cancer treatment
antineoplastic
Research Site
 (5.0 away) Contact site
  • 23 views
  • 27 Sep, 2021
  • +180 other locations
Tezepelumab COPD Exacerbation Study

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 2a Study to Explore the Efficacy and Safety of Tezepelumab in Adults with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD)

copd exacerbation
bronchodilator
severe chronic obstructive pulmonary disease
ct scan
Research Site
 (7.6 away) Contact site
  • 131 views
  • 12 Sep, 2021
  • +107 other locations
A Study of TAK-994 in Adults With Type 1 and Type 2 Narcolepsy

The main aims of the study are: To check for side effects from TAK-994 and check what dose of TAK-994 participants can tolerate. To check what dose range provides adequate relief of narcolepsy symptoms. To check how much TAK-994 stays in the blood of participants, over time. The study will …

Research Carolina Elite - Denver Office
 (9.7 away) Contact site
  • 356 views
  • 22 Sep, 2021
  • +115 other locations
CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such …

docetaxel
estrogen
targeted therapy
carcinoma in situ
trastuzumab
Novant Health Cancer Institute - Huntersville
 (4.6 away) Contact site
  • 50 views
  • 27 Sep, 2021
  • +602 other locations
Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations

Phase 3 study to evaluate the efficacy and safety of a benralizumab in patients with moderate to very severe COPD with a history of frequent COPD exacerbations and elevated peripheral blood eosinophils (300/L). Eligible patients must have a history of 2 moderate and/or severe COPD exacerbations in the previous year …

corticosteroids
eosinophil count
severe chronic obstructive pulmonary disease
antibiotics
bronchodilator
Research Site
 (7.6 away) Contact site
  • 838 views
  • 10 Sep, 2021
  • +438 other locations
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

cancer
pembrolizumab
adjuvant chemotherapy
crizotinib
carcinoma
Lake Norman Hematology Oncology Specialists-Huntersville
 (5.0 away) Contact site
  • 1114 views
  • 26 Sep, 2021
  • +1139 other locations