Charlotte, North Carolina Clinical Trials

A listing of Charlotte, North Carolina clinical trials actively recruiting patient volunteers.

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Found 170 clinical trials
A Study to Evaluate Safety and Effectiveness of mRNA-1273 COVID-19 Vaccine in Healthy Children Between 6 Months of Age and Less Than 12 Years of Age

The primary goal for this study is to evaluate up to 3 dose levels of mRNA-1273 vaccine given to healthy children in 2 doses, 28 days apart.

OnSite Clinical Solutions, LLC
 (4.7 away) Contact site
  • 31 views
  • 24 Jul, 2021
  • +69 other locations
Intramuscular VIR-7831 (Sotrovimab) for Mild/Moderate COVID-19

A Phase 3 randomized, multi-center, open label study to assess the efficacy, safety, and tolerability of monoclonal antibody VIR-7831 (sotrovimab) given intramuscularly versus intravenously for the treatment of mild/moderate coronavirus disease 2019 (COVID-19) in high-risk non-hospitalized patients

Investigative Site
 (6.8 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +66 other locations
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity will be assessed. ABBV-154 is …

stiffness
methotrexate
antirheumatics
rheumatism
DJL Clinical Research, PLLC /ID# 230133
 (9.7 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +292 other locations
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-programmed death ligand 1(PD-[L]1) agent …

transitional cell carcinoma
carcinoma
vinflunine
renal function
advanced urothelial carcinoma
Levine Cancer Institute, Carolinas HealthCare System
 (3.4 away) Contact site
  • 271 views
  • 01 Aug, 2021
  • +592 other locations
Long Term Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

This is an extension study of the Phase 3 Studies 15-AVP-786-301, 15-AVP-786-302, and 17-AVP-786-305, which also allows participants from the Phase 2 Study 12-AVR-131 to be included.

ANI Neurology PLLC dba Alzheimer's Memory Center
 (8.8 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +296 other locations
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

The purpose of this study is to evaluate the objective response rate (complete response [CR]+ partial response [PR]) of the selected dose regimen in participants with metastatic or surgically unresectable urothelial cancers that harbor specific FGFR genomic alterations.

dose regimen
measurable disease
adjuvant chemotherapy
erdafitinib
renal function
Levine Cancer Institute
 (3.4 away) Contact site
  • 40 views
  • 28 Jul, 2021
  • +152 other locations
Traditional Versus Early Aggressive Therapy for Multiple Sclerosis Trial

FDA-approved multiple sclerosis (MS) disease-modifying therapies (DMTs) target the relapsing phase of MS but have minimal impact once the progressive phase has begun. It is unclear if, in the relapsing phase, there is an advantage of early aggressive therapy with respect to preventing long-term disability. The infectious risks and other …

Novant Health Neurology and Sleep
 (4.8 away) Contact site
  • 219 views
  • 25 Jul, 2021
  • +49 other locations
PRISM Study-Pruritus Relief Through Itch Scratch Modulation

To investigate the anti-pruritic efficacy and safety of Nalbuphine ER (NAL ER) tablets in Prurigo Nodularis. Subjects will be randomized to NAL ER (or matching placebo) with the primary endpoint evaluation at Week 14. During the open label extension, subjects who received NAL ER will continue on NAL ER and …

nalbuphine
Study Site 129
 (6.0 away) Contact site
  • 661 views
  • 31 Jul, 2021
  • +85 other locations
Efficacy Safety and Tolerability Study of Apremilast to Treat Early Oligoarticular Psoriatic Arthritis.

This clinical study will test the effects of a drug called apremilast in oligoarticular psoriatic arthritis with less than 5 years of disease duration. In previous studies, apremilast has been shown to be safe and efficacious in reducing signs and symptoms of psoriatic arthritis, as well as improving physical function. …

apremilast
Joint and Muscle Research Institute
 (3.4 away) Contact site
  • 265 views
  • 04 Aug, 2021
  • +268 other locations
A Study in Children With Hyperkalaemia Between Birth and <18 Years of Age to Evaluate Doses of Sodium Zirconium Cyclosilicate (SZC) for Correction of Hyperkalaemia and Effectiveness of Same Dose to Maintain Normokalaemia.

Sodium zirconium cyclosilicate has been shown to be effective and safe in adults for the treatment of hyperkalaemia, and therefore it is expected to be beneficial in children. This study will evaluate the efficacy, safety and tolerability of sodium zirconium cyclosilicate for the treatment of hyperkalaemia in children <18 years …

Research Site
 (4.4 away) Contact site
  • 7 views
  • 29 Jul, 2021
  • +37 other locations