Chapel Hill, North Carolina Clinical Trials

A listing of Chapel Hill, North Carolina clinical trials actively recruiting patient volunteers.

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Found 311 clinical trials
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The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

The objective of the RADIANCE II Pivotal study is to demonstrate the effectiveness and safety of the Paradise System in subjects with Stage 2 hypertension on 0-2 medications at the time of consent. Prior to randomization, subjects will be hypertensive in the absence of hypertension medication.

hypertensive medication
hypertension
antihypertensive drugs
renal angiogram
angiography
The University of North Carolina at Chapel Hill
 (1.6 away) Contact site
  • 877 views
  • 01 Aug, 2021
  • +82 other locations
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Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation (KRYSTAL-7)

This Phase 2 study evaluates the clinical activity and safety of MRTX849 in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS.

pembrolizumab
KRAS
Duke University Medical Center
 (8.0 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • +40 other locations
Phase III Trial Assessing the Efficacy and Safety of PXT3003 in CMT1A Patients

The purpose of this study is to determine whether PXT3003 is effective and safe in the treatment of Charcot-Marie-Tooth disease - Type 1A. This double-blind study will assess in parallel groups 1 dose of PXT3003 compared to Placebo in CMT1A patients treated for 15 months.

UNC Department of Neurology Peripheral Neuropathy Center
 (3.6 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +47 other locations
ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo …

Duke University Hospital (Site 301-006), 2301 Erwin Road
 (8.0 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +38 other locations
Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer

This randomized phase III trial studies digital tomosynthesis mammography and digital mammography in screening patients for breast cancer. Screening for breast cancer with tomosynthesis mammography may be superior to digital mammography for breast cancer screening and may help reduce the need for additional imaging or treatment.

UNC Lineberger Comprehensive Cancer Center
 (9.9 away) Contact site
  • 2012 views
  • 01 Aug, 2021
  • +71 other locations
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix

This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters.

University of North Carolina - Chapel Hill
 (9.9 away) Contact site
  • 219 views
  • 26 Jul, 2021
  • +13 other locations
Study of OT-101 in Treating Myopia

This is a phase III, randomized, double-masked, placebo-controlled, parallel-group, multicenter safety, tolerability, and efficacy study of atropine sulfate 0.01% (OT-101) as an investigational treatment for myopia in pediatric subjects

Scott & Christie and Associates
 (1.1 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +3 other locations
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to …

Novo Nordisk Investigational Site
 (8.6 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +256 other locations
Gastroschisis Outcomes of Delivery (GOOD) Study

The objective of this study is to investigate the hypothesis that delivery at 35 0/7- 35 6/7 weeks in stable patients with gastroschisis is superior to observation and expectant management with a goal of delivery at 38 0/7 - 38 6/7 weeks. To test this hypothesis, we will complete a …

University of North Carolina Hospitals
 (9.9 away) Contact site
  • 228 views
  • 22 Jul, 2021
  • +19 other locations
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-programmed death ligand 1(PD-[L]1) agent …

carcinoma
advanced urothelial carcinoma
adjuvant chemotherapy
vinflunine
pembrolizumab
Duke University
 (9.7 away) Contact site
  • 271 views
  • 01 Aug, 2021
  • +592 other locations