Burlington, North Carolina Clinical Trials

A listing of Burlington, North Carolina clinical trials actively recruiting patient volunteers.

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Found 27 clinical trials
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

tumor cells
erlotinib
squamous cell carcinoma
lung cancer
pembrolizumab
Cone Heath Cancer Center at Mebane
 (12.9 away) Contact site
  • 1103 views
  • 15 Sep, 2021
  • +1139 other locations
Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

This randomized phase III trial studies lymph node dissection and radiation therapy to see how well it works compared to radiation therapy alone in treating patients with breast cancer previously treated with chemotherapy and surgery. Lymph node dissection may remove cancer cells that have spread to nearby lymph nodes in …

ductal carcinoma in situ
tumor cells
sentinel node
endocrine therapy
estrogen
Cone Heath Cancer Center at Mebane
 (12.9 away) Contact site
  • 476 views
  • 22 Jun, 2021
  • +741 other locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

tumor cells
oxaliplatin
monoclonal antibodies
calcium
hysterectomy
Cone Health Cancer Center
 (18.6 away) Contact site
  • 1047 views
  • 15 Sep, 2021
  • +595 other locations
Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

This randomized phase III trial studies how well doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel with or without carboplatin work in treating patients with triple-negative breast cancer. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, …

sentinel node
tumor cells
pet/ct scan
estrogen
epidermal growth factor receptor
Cone Heath Cancer Center at Mebane
 (12.9 away) Contact site
  • 814 views
  • 24 Jan, 2021
  • +810 other locations
Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

This randomized phase III trial studies how well paclitaxel, trastuzumab, and pertuzumab with or without atezolizumab works in treating patients with breast cancer that has spread to other parts of the body (metastatic). Chemotherapy drugs, such as paclitaxel, work in different ways to stop the growth of tumor cells, either …

tumor cells
estrogen
measurable disease
monoclonal antibodies
staining intensity
Cone Heath Cancer Center at Mebane
 (12.9 away) Contact site
  • 445 views
  • 15 Sep, 2021
  • +459 other locations
Redesigning Systems to Improve Quality for Hospitalized Patients

Despite recent improvements, healthcare systems are still a long way from consistently delivering high quality care to hospitalized patients. In this study, the research team is assisting hospitals in implementing a set of complementary, mutually reinforcing interventions to redesign care for hospitalized medical patients. The investigators anticipate the interventions will …

Indiana University Ball Memorial Hospital
 (429.6 away) Contact site
  • 168 views
  • 25 Jul, 2021
  • +3 other locations
Researching the Effect of Aerobic Exercise on Cancer

This study is being done to answer the following question: Will aerobic exercise (exercise that stimulates and strengthens the heart and lungs, and improves the body's use of oxygen) change the biomarkers (signs of disease) found in the blood?

primary cancer
hormone therapy
endocrine therapy
immunostimulants
cancer treatment
LABORATORY CORPORATION OF AMERICA HOLDINGS (Data or Specimen Analysis Only)
 (5.2 away) Contact site
  • 0 views
  • 04 Jun, 2021
  • +10 other locations
KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated Nonsquamous NSCLC

This is a Phase 2, randomized, multicenter, double-blind study of the glutaminase inhibitor telaglenastat with standard-of-care pembrolizumab and chemotherapy versus placebo with standard-of-care pembrolizumab and chemotherapy for first line treatment of metastatic disease in patients with KEAP1/NRF2-mutated, stage IV, nonsquamous, non-small cell lung cancer (NSCLC). The study primary endpoints are …

LKB1
measurable disease
proto-oncogene tyrosine-protein kinase ros
systemic therapy
pembrolizumab
Cone Health at Alamance Regional
 (5.2 away) Contact site
  • 389 views
  • 11 Sep, 2021
  • +106 other locations
Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial)

This phase II Lung-MAP non-Match treatment trial studies how well ramucirumab and pembrolizumab work versus standard of care in treating patients with non-small cell lung cancer that is stage IV or has come back. Immunotherapy with monoclonal antibodies, such as ramucirumab and pembrolizumab, may help the body's immune system attack …

tumor cells
major surgery
measurable disease
insulin
ramucirumab
Cone Health Cancer Center at Alamance Regional
 (5.2 away) Contact site
  • 86 views
  • 25 Jan, 2021
  • +628 other locations
A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioblastoma With Elevated Mutational Burden

This phase II trial studies the effect of immunotherapy drugs (ipilimumab and nivolumab) in treating patients with glioblastoma that has come back (recurrent) and carries a high number of mutations. Cancer is caused by changes (mutations) to genes that control the way cells function. Tumors with high number of mutations …

Cone Heath Cancer Center at Mebane
 (12.9 away) Contact site
  • 0 views
  • 08 Sep, 2021
  • +311 other locations