Asheville, North Carolina Clinical Trials

A listing of Asheville, North Carolina clinical trials actively recruiting patient volunteers.

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Found 81 clinical trials
A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer Compared to Nab-paclitaxel+Gemcitabine Treatment

The purpose of this study is to look at the efficacy and safety of Irinotecan liposome injection in combination with other approved drugs used for cancer therapy, namely 5 fluorouracil/leucovorin (5FU/LV) plus oxaliplatin compared to nab-paclitaxel + gemcitabine treatment in improving the overall survival of patients not previously treated for …

Messino Cancer Center
 (3.8 away) Contact site
  • 31 views
  • 03 Aug, 2021
  • +273 other locations
Fixed-Dose Trial in Early Parkinson's Disease (TemPo-1)

The purpose of this study is to evaluate the clinical efficacy, safety and pharmacokinetics (PK) of 2 fixed doses of tavapadon and placebo in participants with early Parkinson's Disease.

bradykinesia
parkinsonism
impulse control disorder
hallucinations
antiparkinsonian agents
Asheville Neurology Consultants
 (3.8 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +76 other locations
Study of Evobrutinib in Participants With RMS (evolutionRMS 2)

The study is to evaluate the efficacy and safety of evobrutinib administered orally twice daily versus Teriflunomide (Aubagio), administered orally once daily in participants with Relapsing Multiple Sclerosis (RMS).

aubagio
teriflunomide
evobrutinib
Research Site 736
 (0.3 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +258 other locations
Flexible-Dose Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations (TemPo-3)

The purpose of this study is to assess the effect of tavapadon on the change from baseline in total daily hours of "on" time without troublesome dyskinesia in L-Dopa-treated participants with Parkinson's Disease (PD) who are experiencing motor fluctuations.

bradykinesia
carbidopa
mao-b inhibitor
levodopa
dyskinesia
Asheville Neurology Consultants
 (3.8 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +101 other locations
OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)

A 2-year phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.

COAST Investigational Site
 (2.2 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +50 other locations
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

This Phase 3 study will evaluate the efficacy and safety of KSI-301 compared to aflibercept, in participants with neovascular (wet) age-related macular degeneration (wAMD)

Western Carolina Retinal Associate PA
 (4.5 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +65 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

hydrochlorothiazide
major surgery
vitamin d
metastatic colorectal adenocarcinoma
open biopsy
AdventHealth Infusion Center Asheville
 (4.5 away) Contact site
  • 72 views
  • 27 Jul, 2021
  • +978 other locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

nervous
autologous stem cell infusion
stem cell infusion
blood transfusion
interleukins
BI-LO Charities Children's Cancer Center
 (55.6 away) Contact site
  • 997 views
  • 04 Aug, 2021
  • +113 other locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

combination chemotherapy
investigational agent
pulmonary disease
hysterectomy
antibiotics
AdventHealth Infusion Center Asheville
 (2.2 away) Contact site
  • 1047 views
  • 01 Aug, 2021
  • +589 other locations
Reducing Lung CongestIon Symptoms in Advanced Heart Failure

The objective of the RELIEVE-HF study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System by improving meaningful clinical outcomes in patients with New York Heart Association (NYHA) functional Class II, Class III, or ambulatory Class IV heart failure (HF), irrespective of left ventricular …

medical therapy
heart failure with preserved ejection fraction
heart failure
pulmonary congestion
ejection fraction
Mission Hospital
 (0.3 away) Contact site
  • 48 views
  • 24 Jul, 2021
  • +132 other locations