Additional Locations, North Carolina Clinical Trials

A listing of Additional Locations, North Carolina clinical trials actively recruiting patient volunteers.

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Found 168 clinical trials
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating …

anticonvulsants
tumor cells
cyclophosphamide
platelet count
medulloblastoma
Mission Hospital Inc-Memorial Campus
 (6.2 away) Contact site
  • 119 views
  • 03 Sep, 2021
  • +136 other locations
Veliparib Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

This phase II trial studies how well veliparib, radiation therapy, and temozolomide work in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations. Poly adenosine diphosphate (ADP) ribose polymerases (PARPs) are proteins that help repair DNA mutations. PARP inhibitors, such as veliparib, can keep PARP from …

glioblastoma multiforme
tumor cells
platelet count
glomerular filtration rate
temozolomide
Mission Hospital
 (6.2 away) Contact site
  • 403 views
  • 22 Sep, 2021
  • +111 other locations
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different …

cancer therapy
liver cancer
tumor cells
fluorouracil
vincristine
Mission Hospital Inc-Memorial Campus
 (6.2 away) Contact site
  • 178 views
  • 01 Aug, 2021
  • +137 other locations
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

Prospective, controlled, multicenter clinical investigation with three trial cohorts: Randomized, Non-Randomized, and Mitral Annular Calcification (MAC). Subjects in the Randomized cohort will be randomized in a 1:1 ratio to the trial device or to the MitraClip system. Subjects in the Non-Randomized and MAC cohorts will receive the trial device. The …

mitral annular calcification
mitral regurgitation
mitral valve repair
mitral valve disease
regurgitation
Mission Health & Hospitals
 (6.2 away) Contact site
  • 323 views
  • 17 Jun, 2021
  • +77 other locations
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

axillary lymph node dissection
endocrine therapy
erbb2
tamoxifen
aromatase inhibitor
Mission Hospital
 (6.2 away) Contact site
  • 598 views
  • 23 Sep, 2021
  • +323 other locations
Reducing Lung CongestIon Symptoms in Advanced Heart Failure

The objective of the RELIEVE-HF study is to provide reasonable assurance of safety and effectiveness of the V-Wave Interatrial Shunt System by improving meaningful clinical outcomes in patients with New York Heart Association (NYHA) functional Class II, Class III, or ambulatory Class IV heart failure (HF), irrespective of left ventricular …

congestion
ejection fraction
b-type natriuretic peptide
heart failure with preserved ejection fraction
medical therapy
Mission Hospital
 (5.9 away) Contact site
  • 48 views
  • 21 Aug, 2021
  • +133 other locations
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying …

thromboembolism
dabigatran
vitamin k antagonist
coronary artery bypass graft
ticagrelor
Mission Hospital
 (6.2 away) Contact site
  • 112 views
  • 23 Sep, 2021
  • +79 other locations
Phase 3 Study of SNF472 for Calciphylaxis

The primary objectives are to assess the efficacy, safety, and tolerability of SNF472 compared to placebo when added to background care for the treatment of calciphylaxis (CUA).

DaVita Clinical Research
 (5.9 away) Contact site
  • 21 views
  • 19 Jul, 2021
  • +62 other locations
Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF

The study is a prospective, multi-center, non-randomized, unblinded worldwide pre-market clinical study. The purpose of the study is to provide data demonstrating the safety and effectiveness of the PulseSelect PFA System for the treatment of atrial fibrillation (AF). The study will also provide first in human insights into clinical safety …

fibrillation
pulmonary vein isolation
antiarrhythmic drug
Mission Hospital
 (6.2 away) Contact site
  • 17 views
  • 22 Aug, 2021
  • +35 other locations
A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy

The XEN1101 Phase 2 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and tolerability of increasing doses of XEN1101 administered as adjunctive treatment in adult patients diagnosed with focal epilepsy, followed by an optional open-label extension (OLE).

adjunctive treatment
adjunctive therapy
seizure
Asheville Neurology Specialists, PA
 (6.4 away) Contact site
  • 104 views
  • 25 Jan, 2021
  • +81 other locations