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St. Charles, Missouri Clinical Trials

A listing of St. Charles, Missouri clinical trials actively recruiting patient volunteers.

RESULTS

Found (13) clinical trials

Dabrafenib Trametinib and Navitoclax in Treating Patients With BRAF Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

PRIMARY OBJECTIVES: I. To determine the maximum tolerated dose (MTD), toxicity, and safety profile of navitoclax when given in combination with dabrafenib and trametinib in patients with BRAF-mutant solid tumors. (Phase I) II. To estimate the complete response (CR) rate in patients with BRAF-mutant melanoma treated with dabrafenib, trametinib, and ...

Phase

6.77 miles

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Safety and Efficacy of MEDI0457 and Durvalumab in Patients With HPV Associated Recurrent/Metastatic Head and Neck Cancer

This is a Phase 1b/2a, open-label, multi-center study to evaluate the safety and tolerability, anti-tumor activity, and immunogenicity of MEDI0457 (also known as INO 3112) a HPV DNA vaccine in combination with durvalumab (also known as MEDI4736) which is a human monoclonal antibody directed against PD-L1, which blocks the interaction ...

Phase

7.13 miles

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Pomalidomide and Dexamethasone With or Without Ixazomib in Treating Patients With Relapsed Multiple Myeloma

PRIMARY OBJECTIVES: I. To establish the maximum tolerated dose (MTD) for combination therapy pomalidomide/dexamethasone/ixazomib. (Phase I) II. To assess whether the combination of pomalidomide/dexamethasone/ixazomib improves progression-free survival (PFS) relative to pomalidomide/dexamethasone. (Phase II) SECONDARY OBJECTIVES: I. To determine dose-limiting toxicities (DLTs). (Phase I) II. To analyze type and grade of ...

Phase

9.39 miles

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Proton or Photon RT for Retroperitoneal Sarcomas

While being screened to determine eligibility for this study you may choose to participate in an additional blood sample for circulating DNA and a genomic DNA sample. Since we are looking for the highest dose of Radiation Therapy that can be administered safely without severe or unmanageable side effects in ...

Phase

9.39 miles

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Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma

PRIMARY OBJECTIVES: I. To determine the safety and maximum tolerable dose of sapanisertib (MLN0128 [TAK-228]) within this patient population. (Phase I) II. To determine the differences in progression-free survival (PFS) in patients with sarcoma who receive MLN0128 (TAK-228) as compared to pazopanib (pazopanib hydrochloride). (Phase II) SECONDARY OBJECTIVES: I. To ...

Phase

9.39 miles

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Electrical Acupuncture and Laser Therapy for Low Back Pain

The purpose of the study is to investigate the effects of electroacupuncture and laser therapy to treat chronic low back pain.

Phase

9.65 miles

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The Effect of Vibration Therapy on the Bone Density of the Tiba in Patients With Spinal Cord Injury

The purpose of this investigation is to determine the effect of lower limb vibration therapy on bone density in the tibia in patients with spinal cord injury. The second purpose is to assess the neuromuscular junction variability at the motor units of the tibialis anterior muscle after a sequence of ...

Phase

9.82 miles

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Standard Process 21 Day Purification Program Project

Elevated low-density lipoprotein (LDL) cholesterol concentrations are a risk factor for cardiovascular diseases. (1) Cholesterol lowering drugs are the most frequently prescribed medications in the U.S. and are known to have muscle, kidney and liver side effects for some users. Recent reviews conclude that benefits outweigh risks reporting statin and ...

Phase

9.82 miles

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The Effect of Acupuncture on Blood Pressure and Heart Rate Variability (HRV)

Outcome measurements include blood pressure and heart rate variability.

Phase

9.82 miles

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Study to Evaluate the Safety and Preliminary Efficacy of IDCT a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration

This is a Phase I, firstinhuman, randomized, doubleblind, vehicle and placebo-controlled, parallelgroup, multi-center study in subjects with singlelevel, symptomatic lumbar intervertebral disc degeneration (>6 months) and unresponsive to conservative therapy for at least 3 months. The study will compare single intradiscal injections of high and low dose IDCT with two ...

Phase

9.82 miles

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