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Columbia, Missouri Clinical Trials

A listing of Columbia, Missouri clinical trials actively recruiting patient volunteers.

RESULTS

Found (131) clinical trials

Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections

The primary hypothesis of this study is that in addition to standard of care treatment (which includes surgical intervention, antimicrobial therapy and critical care support for organ dysfunction or failure), AB103 will demonstrate a clinically significant treatment benefit over placebo. This hypothesis will be addressed by measuring the effect of ...

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Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function

The notion that cellular stress lowers insulin-induced vasodilation is largely founded on ex vivo studies and experiments in rodents. However, it remains unknown if maintenance of cellular function with the use of dietary supplement tauroursodeoxycholic acid enhances vascular function in humans. The investigators test the hypothesis that daily administration of ...

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Low Intensity Physical Activity During Sitting on Glycemic Control and Vascular Function in Obese Individuals

Experimental Design: Twenty obese subjects with metabolic syndrome will complete 2 study days with measures vascular function and glycemic control. On one study day, the subjects will sit quietly for 3 hours and on the second study day subjects will sit quietly for 3 hours and simultaneously move their legs ...

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Lowering Impaired Fasting Glucose Levels With Exercise

In individuals with type 2 diabetes (T2D), chronically elevated glucose and insulin levels result in numerous health complications. Maintaining tight glucose control is difficult for individuals with T2D, particularly in the postprandial period and in the morning period just prior to waking. In the postprandial period, the combined effect of ...

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Combined Effects of Early Behavioral Intervention and Propranolol on ASD

The investigators' specific aim is to examine the effects of serial doses of propranolol in combination with early intensive behavioral intervention on social interaction, and secondarily on language tasks, anxiety, adaptive behaviors, and global function in children with autism in a double-blinded, placebo-controlled trial. The investigators will also examine whether ...

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Aripiprazole Abilify Maintena Collaborative Clinical Protocol

This is an open-label, multi-center, longitudinal, within-subject comparison study of the effects of aripiprazole once monthly on 30-, 90-, and 180-day psychiatric re-hospitalization rates following hospital discharge in subjects with schizophrenia compared with prior psychiatric hospitalization rates while on oral antipsychotics. Prospective subjects will undergo screening for eligibility for entry ...

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Predicting Treatment Response to Memantine in Autism Using Magnetic Resonance Spectroscopy

Background and Rationale Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental disorder characterized by early childhood onset of marked deficiencies in social and communication skills and presence of restrictive, repetitive behaviors. Its phenotypic heterogeneity makes studying ASD and its treatment a challenging task. Currently, only two FDA approved ...

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Trial of Propranolol in Children and Youth With Autism Spectrum Disorder and Predictors of Response

The specific aim of this study is to examine the effects of serial doses of propranolol on social interaction, and secondarily on language tasks, anxiety, adaptive behaviors, and global function in high functioning adults and adolescents with autism in a double-blinded, placebo-controlled trial. The investigators will also examine whether response ...

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Phase 2 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury

Phase 2 randomized, placebo controlled study assessing the efficacy (complete recovery from AKI) and safety of Reltecimod in patients with suspected or confirmed abdominal sepsis (planned or completed surgical (laparotomy or laparoscopy) or interventional radiologic procedures for control of underlying abdominal infection within 24 hours of evaluation by medical personnel), ...

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Patients' Perspectives About a Pain Education Video

The long-term goal is to reduce disability in patients with chronic pain by improving communication about pain among patients, caregivers, and health care providers (HCPs). The proposed study addresses the long-term goal by conducting a project that investigates the validation and contradiction of patients' preexisting pain beliefs during pain education. ...

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