St. Cloud, Minnesota Clinical Trials

A listing of St. Cloud, Minnesota clinical trials actively recruiting patient volunteers.

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Found 64 clinical trials
Randomized Trial of Standard Chemotherapy Alone or Combined With Atezolizumab as Adjuvant Therapy for Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

atezolizumab
immunosuppressive
hysterectomy
pulmonary disease
corticosteroids
Saint Cloud Hospital
 (2.1 away) Contact site
  • 1145 views
  • 15 Sep, 2022
  • +545 other locations
A Randomized Phase II/III Trial of De-Intensified Radiation Therapy for Patients With Early-Stage, P16-Positive, Non-Smoking Associated Oropharyngeal Cancer

This phase II/III trial studies how well a reduced dose of radiation therapy works with nivolumab compared to cisplatin in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer that is early in its growth and may not have spread to other parts of the body (early-stage), and is not associated …

pet-ct scan
hysterectomy
administration intravenous
tumor cells
neutrophil count
Coborn Cancer Center at Saint Cloud Hospital
 (2.1 away) Contact site
  • 196 views
  • 15 Sep, 2022
  • +226 other locations
The PEERLESS Study (PEERLESS)

This study is a prospective, multicenter, randomized controlled trial of the FlowTriever System compared to Catheter-Directed Thrombolysis (CDT) for acute intermediate-high-risk pulmonary embolism (PE), and includes a non-randomized cohort of up to 150 subjects with an absolute contraindication to thrombolytics.

thrombectomy
troponin
angiography
ctpa
pulmonary angiography
CentraCare St. Cloud Hospital
 (2.1 away) Contact site
  • 5 views
  • 15 Sep, 2022
  • +32 other locations
PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated REnal Cell CancEr [PDIGREE]

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

interleukin-2
atezolizumab
nephrectomy
tumor cells
systemic therapy
Coborn Cancer Center at Saint Cloud Hospital
 (2.1 away) Contact site
  • 319 views
  • 19 Sep, 2022
  • +344 other locations
MAIN-CAV: Phase III Randomized Trial of Maintenance Cabozantinib and Avelumab vs Maintenance Avelumab After First-Line Platinum-Based Chemotherapy in Patients With Metastatic Urothelial Cancer

This phase III trial compares the effect of adding cabozantinib to avelumab versus avelumab alone in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy …

Coborn Cancer Center at Saint Cloud Hospital
 (2.1 away) Contact site
  • 0 views
  • 19 Sep, 2022
  • +80 other locations
ACURATE IDE: Transcatheter Replacement of Stenotic Aortic Valve Through Implantation of ACURATE in Subjects InDicatEd for TAVR

To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR.

ejection fraction
aortic valve replacement
regurgitation
stenosis
aortic valve stenosis
Centracare Heart and Vascular Center
 (2.1 away) Contact site
  • 84 views
  • 19 Sep, 2022
  • +84 other locations
A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%) (FINEARTS-HF)

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits …

ejection fraction
heart disease
diuretic therapy
nt-probnp
heart failure
St. Cloud Hospital
 (2.1 away) Contact site
  • 84 views
  • 19 Sep, 2022
  • +597 other locations
Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO (ACCIO)

This phase III ALCHEMIST trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and …

platelet count
gemcitabine
pembrolizumab
carboplatin
carcinoma
Coborn Cancer Center at Saint Cloud Hospital
 (1.7 away) Contact site
  • 136 views
  • 20 Sep, 2022
  • +466 other locations
SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial (SMART)

The purpose of this trial is to generate clinical evidence on valve safety and performance of self-expanding (SE) versus balloon-expandable (BE) transcatheter aortic valve replacement (TAVR) in subjects with a small aortic annulus and symptomatic severe native aortic stenosis. Additionally, a stress echocardiography sub-study will be conducted as part of …

stenosis
aortic valve replacement
St. Cloud Hospital
 (2.1 away) Contact site
  • 8 views
  • 23 Sep, 2022
  • +84 other locations
WATCHMAN FLX Versus NOAC for Embolic ProtectION in in the Management of Patients With Non-Valvular Atrial Fibrillation (CHAMPION-AF)

The primary objective of this study is to determine if left atrial appendage closure (LAAC) with the WATCHMAN FLX device is a reasonable alternative to non-vitamin K oral anticoagulants in patients with non-valvular atrial fibrillation.

left atrial appendage closure
hypertension
vitamin k
anticoagulants
fibrillation
Centracare Heart and Vascular Center
 (2.1 away) Contact site
  • 131 views
  • 20 Sep, 2022
  • +147 other locations