Minneapolis, Minnesota Clinical Trials

A listing of Minneapolis, Minnesota clinical trials actively recruiting patient volunteers.

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Found 485 clinical trials
A Study of Tucatinib Plus Trastuzumab Deruxtecan in HER2+ Breast Cancer (HER2CLIMB-04)

This trial studies how well the drug tucatinib works when given with trastuzumab deruxtecan (T-DXd). It will also look at what side effects happen when these drugs are given together. A side effect is anything a drug does besides treating cancer. Participants in this trial have HER2-positive (HER2+) breast cancer …

taxane
her2/neu-positive breast cancer
mammogram
erbb2
HER2
Allina Health Cancer Institute
 (3.1 away) Contact site
  • 0 views
  • 07 Oct, 2022
  • +30 other locations
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

Background Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia. Allogenic stem cell transplants encourage the growth of new bone marrow to replace that of the recipient. Because stem cell …

cell transplantation
fludarabine
paroxysmal nocturnal hemoglobinuria
anemia severe
methotrexate
National Marrow Donor Program (NMDP)
 (0.1 away) Contact site
  • 52 views
  • 07 Oct, 2022
  • +2 other locations
A Safety Study of SGN-LIV1A in Breast Cancer Patients

This study will examine the safety and tolerability of ladiratuzumab vedotin (LV) in patients with metastatic breast cancer. LV will be given alone or in combination with trastuzumab.

hormone therapy
trastuzumab
measurable disease
triple negative breast cancer
stage iv breast cancer
University of Minnesota
 (1.9 away) Contact site
  • 323 views
  • 07 Oct, 2022
  • +28 other locations
Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the body which in turn may …

residual tumor
carboplatin
oophorectomy
cytoreductive surgery
estrogen
Hennepin County Medical Center
 (0.8 away) Contact site
  • 207 views
  • 07 Oct, 2022
  • +452 other locations
Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers

This phase II trial studies how well ramucirumab and paclitaxel or the FOLFIRI regimen (leucovorin calcium, fluorouracil, and irinotecan hydrochloride) work in treating patients with small bowel cancers that have spread extensively to other anatomic sites (advanced) or are no longer responding to treatment (refractory). Ramucirumab is a monoclonal antibody …

Hennepin County Medical Center
 (0.8 away) Contact site
  • 12 views
  • 07 Oct, 2022
  • +425 other locations
Naptumomab Estafenatox (NAP) in Combination With Docetaxel Following Obinutuzumab Pretreatment in Subjects With Checkpoint Inhibitor Pretreated Advanced or Metastatic NSCLC (NT-NAP-102-1)

Phase 2a Open-Label, Multicenter Trial of Naptumomab Estafenatox (NAP), on Days 1-4, in Combination with Docetaxel, on Day 5, Following Obinutuzumab Pretreatment, on Days -13 and -12. Treatment cycles will be 21 days in duration.

docetaxel
cancer chemotherapy
EGFR
platinum-based chemotherapy
NeoTX - 10304
 (1.6 away) Contact site
  • 0 views
  • 07 Oct, 2022
  • +11 other locations
Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age

The purpose of this study is to evaluate the pharmacokinetics, safety, tolerability and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in CF participants with at least 1 triple combination responsive (TCR) mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

cftr gene
tezacaftor
fibrosis
Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota
 (1.6 away) Contact site
  • 0 views
  • 07 Oct, 2022
  • +7 other locations
Study of HST5040 in Subjects With Propionic or Methylmalonic Acidemia (HERO)

This is an interventional study to assess the safety, PK, and efficacy of HST5040 in 12 subjects - 6 with Methylmalonic Acidemia (MMA) and 6 with Propionic Acidemia (PA). The study consists of 3 parts: Part A: Open-label, within-subject, dose escalation study in PA and MMA subjects ≥ 2 years …

University of Minnesota
 (1.9 away) Contact site
  • 0 views
  • 07 Oct, 2022
  • +10 other locations
Implementation and Effectiveness Trial of HN-STAR (HN-STAR)

People who have been treated for head and neck cancer (HNC survivors) can experience serious consequences from their cancer and its treatment, ongoing risks of new cancers, and other unrelated illnesses. These concerns pose challenges to the provision of comprehensive care to HNC survivors. We created HN-STAR to facilitate and …

dental caries
carcinoma
squamous cell carcinoma of head and neck
squamous cell carcinoma
Park Nicollet Clinic - Saint Louis Park
 (4.1 away) Contact site
  • 0 views
  • 07 Oct, 2022
  • +24 other locations
Control-IQ Technology for High Insulin Users With Type 1 Diabetes (Higher-IQ)

A prospective, single-arm study of 13 weeks of home use of the t:slim X2 insulin pump with Control-IQ technology in individuals with type 1 diabetes who will plan to use at least one basal rate > 3 units/hr.

glucagon
diabetes
hemoglobin a1c
hypoglycemia
hyperglycemia
International Diabetes Center
 (4.1 away) Contact site
  • 0 views
  • 07 Oct, 2022
  • +3 other locations