Maplewood, Minnesota Clinical Trials

A listing of Maplewood, Minnesota clinical trials actively recruiting patient volunteers.

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Found 137 clinical trials
Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma

This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.

tumor cells
intracranial meningioma
central pathology review
step 2
ct scan
Regions Hospital
 (4.6 away) Contact site
  • 1040 views
  • 15 Sep, 2022
  • +121 other locations
Randomized Phase II/III Study of Nivolumab Plus Ipilimumab Plus Sargramostim Versus Nivolumab Plus Ipilimumab in Patients With Unresectable Stage III or Stage IV Melanoma

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may …

tumor cells
immunomodulators
monoclonal antibody therapy
diabetes
metastatic melanoma
Minnesota Oncology Hematology PA-Woodbury
 (3.5 away) Contact site
  • 162 views
  • 17 Sep, 2022
  • +415 other locations
A Phase III Randomized Study of Maintenance Nivolumab Versus Observation in Patients With Locally Advanced, Intermediate Risk HPV Positive OPSCC

This phase III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has …

Minnesota Oncology Hematology PA-Woodbury
 (3.4 away) Contact site
  • 428 views
  • 18 Sep, 2022
  • +460 other locations
A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma

This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the …

tumor cells
lymphoma
positron emission tomography/computed tomography
vinblastine
mixed cellularity hodgkin lymphoma
Minnesota Oncology Hematology PA-Maplewood
 (4.5 away) Contact site
  • 101 views
  • 18 Sep, 2022
  • +350 other locations
PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated REnal Cell CancEr [PDIGREE]

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

tumor cells
atezolizumab
systemic therapy
programmed cell death 1 ligand 1
kidney cancer
Minnesota Oncology Hematology PA-Maplewood
 (4.5 away) Contact site
  • 319 views
  • 19 Sep, 2022
  • +344 other locations
MAIN-CAV: Phase III Randomized Trial of Maintenance Cabozantinib and Avelumab vs Maintenance Avelumab After First-Line Platinum-Based Chemotherapy in Patients With Metastatic Urothelial Cancer

This phase III trial compares the effect of adding cabozantinib to avelumab versus avelumab alone in treating patients with urothelial cancer that has spread to other places in the body (metastatic). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy …

Regions Hospital
 (4.6 away) Contact site
  • 0 views
  • 19 Sep, 2022
  • +80 other locations
ACURATE IDE: Transcatheter Replacement of Stenotic Aortic Valve Through Implantation of ACURATE in Subjects InDicatEd for TAVR

To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects with severe native aortic stenosis who are indicated for TAVR.

aortic valve replacement
ejection fraction
cancer
transcatheter aortic valve implantation
stenosis
St. Joseph's Hospital-St. Paul
 (6.2 away) Contact site
  • 84 views
  • 19 Sep, 2022
  • +84 other locations
A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Finerenone on Morbidity and Mortality in Participants With Heart Failure (NYHA II-IV) and Left Ventricular Ejection Fraction ≥ 40% (LVEF ≥ 40%) (FINEARTS-HF)

The purpose of this study is to evaluate the effect of finerenone compared to placebo (a tablet without active substance) in the reduction of cardiovascular death (generally meaning death due to disease of the heart or blood vessels) and total Heart Failure (HF) events, including HF hospitalization and urgent visits …

ejection fraction
stroke
heart failure
heart disease
natriuretic peptide
M Health Fairview
 (4.9 away) Contact site
  • 84 views
  • 19 Sep, 2022
  • +597 other locations
A Randomized, Double-blind, Placebo-controlled, Active Comparator Phase 2/3 Study of Tucatinib in Combination With Trastuzumab, Ramucirumab, and Paclitaxel in Subjects With Previously Treated, Locally-advanced Unresectable or Metastatic HER2+ Gastric or Gastroesophageal Junction Adenocarcinoma (GEC) (MOUNTAINEER-02)

This study is being done to see if tucatinib with trastuzumab, ramucirumab and paclitaxel works better than ramucirumab and paclitaxel to treat HER2-positive (HER2+) cancer of the gut (stomach or gastroesophageal cancer). This study will also look at what side effects happen when participants take this combination of drugs. A …

Minnesota Oncology Hematology P.A.
 (5.9 away) Contact site
  • 0 views
  • 19 Sep, 2022
  • +39 other locations
A Phase 1b Multicentre, Open-label, Modular, Dose-finding and Dose-expansion Study to Explore the Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of Trastuzumab Deruxtecan (T-DXd) in Combination With Other Anti-cancer Agents in Patients With Metastatic HER2-low Breast Cancer (DESTINY-Breast08) (DB-08)

DESTINY-Breast 08 will investigate the safety, tolerability, PK and preliminary anti-tumour activity of T-DXd in combination with other therapies in patients with Metastatic HER2-low Advanced or Metastatic Breast Cancer

Research Site
 (6.2 away) Contact site
  • 0 views
  • 19 Sep, 2022
  • +29 other locations