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Takoma Park, Maryland Clinical Trials

A listing of Takoma Park, Maryland clinical trials actively recruiting patient volunteers.

RESULTS

Found (16) clinical trials

Fish Skin Compared to Cadaver Skin as Temporary Cover for Full Thickness Burns

Mortality after severe burns has diminished during the last decades and survival is no longer considered the primary end point of care. More attention is paid to the final functional and cosmetic outcome of the affected area but outcomes are still far from optimal. For the time being, one of ...

Phase N/A

3.88 miles

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A Study Assessing the Safety Tolerability and Efficacy of RO7171009 in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

This study will evaluate the safety, tolerability, and efficacy of intravitreal injections of RO7171009 administered every 4 weeks (Q4W) or every 8 weeks (Q8W) for approximately 76 weeks in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) compared with sham control.

Phase

4.38 miles

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Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)

Approximately 650 adult participants (18 to 70 years old, inclusive) with DM1 will be enrolled at 15 centers (up to 70 patients will be recruited at each site). No treatment will be administered as part of this study. Participants will receive standard of care as determined by the investigators. Study ...

Phase N/A

5.58 miles

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Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma

PRIMARY OBJECTIVES: I. Determine the toxicities and maximum tolerated dose (MTD) of birinapant concurrent with intensity modulated re-irradiation therapy (IMRRT). SECONDARY OBJECTIVES: I. Determine the objective response rate of patients with locoregionally recurrent head and neck squamous cell carcinoma (HNSCC) treated with re-irradiation and birinapant. II. Determine the local-regional control, ...

Phase

5.67 miles

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Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

Background BRCA1-Associated Protein-1 (BAP1), a deubiquitinase involved in regulating DNA repair enzymes, is believed to be a prominent mutation in malignant mesothelioma Germline mutations involving BAP1 have been reported in familial studies. These have been associated with a higher likelihood of mesothelioma as well as several other malignancies, including uveal ...

Phase N/A

5.67 miles

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Mechanism of Action Underlying Ketamine s Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

Objective Work by our group and others has demonstrated that a single intravenous dose of the glutamatergic modulator ketamine consistently produces rapid (within two hours), robust, and relatively sustained (approximately one to two weeks) antidepressant effects in patients with treatment-resistant major depressive disorder (MDD) and bipolar depression. Although ketamine is ...

Phase

5.67 miles

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Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

Leptin is an adipocyte-derived hormone that can be thought of as a signal from adipose tissue to the rest of the body conveying information about long-term nutritional status. Patients with the very rare condition of generalized lipodystrophy have leptin deficiency secondary to lack of adipose tissue. The combination of leptin ...

Phase

5.67 miles

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T-cells Expressing an Anti-SLAMF7 CAR for Treating Multiple Myeloma

Background Multiple myeloma (MM) is a nearly always incurable malignancy of plasma cells. T cells can be genetically modified to express chimeric antigen receptors (CARs) that target malignancy-associated antigens. SLAMF7 is highly and uniformly expressed on MM cells but is absent on normal tissues except for some leukocytes, including a ...

Phase

5.67 miles

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Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess

Growth hormone excess is a rare and potentially lethal condition associated with hypersecretion of growth hormone (GH), usually by a pituitary tumor or hyperplasia. When it occurs prior to the complete fusion of growth plates, it leads to pathological tall stature, and it is called gigantism. After the fusion of ...

Phase

5.67 miles

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Mapping Institutional Identities and the Production of Ethics

Objective: The study has two objectives. The primary objective is to explore what dynamics exist within IRB committees, how members in each role interact with each other, and how these interactions affect participation in the deliberation/decision-making process. The secondary objective of this research is to explore what each member/staff perceives ...

Phase N/A

5.67 miles

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