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Silver Spring, Maryland Clinical Trials

A listing of Silver Spring, Maryland clinical trials actively recruiting patient volunteers.

RESULTS

Found (18) clinical trials

Phase 3, 56-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Utilizing Patient-Reported and Radiographic Outcomes to Evaluate the Efficacy and Safety of a Single Injection of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects

Phase

2.45 miles

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Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1)

Approximately 650 adult participants (18 to 70 years old, inclusive) with DM1 will be enrolled at 15 centers (up to 70 patients will be recruited at each site). No treatment will be administered as part of this study. Participants will receive standard of care as determined by the investigators. Study ...

Phase N/A

5.24 miles

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Malarone Pharmacokinetics Under Simulated Physiologic Stressors of Deployment

A clinical trial under controlled heat exposure and moderate intensity exercise, determined by VO2max testing and calibration, to determine if physiologic changes during heat exposure and exercise change the pharmacokinetics of malarone to a degree that falls outside the range of that which is considered bioequivalent or 80-125% concentration using ...

Phase

5.24 miles

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Safety and Efficacy of Pegvisomant in Children With Growth Hormone Excess

Growth hormone excess is a rare and potentially lethal condition associated with hypersecretion of growth hormone (GH), usually by a pituitary tumor or hyperplasia. When it occurs prior to the complete fusion of growth plates, it leads to pathological tall stature, and it is called gigantism. After the fusion of ...

Phase

5.27 miles

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Mapping Institutional Identities and the Production of Ethics

Objective: The study has two objectives. The primary objective is to explore what dynamics exist within IRB committees, how members in each role interact with each other, and how these interactions affect participation in the deliberation/decision-making process. The secondary objective of this research is to explore what each member/staff perceives ...

Phase N/A

5.27 miles

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A Clinical Study of Anetumab Ravtansine in Adults With Solid Tumors Who Have Been Treated in Previous Bayer-sponsored Anetumab Ravtansine Studies

The primary objective of the study is to collect long-term safety information on anetumab ravtansine and to enable patients, who received an anetumab ravtansine-containing treatment in any Bayer-sponsored anetumab ravtansine parent study, to continue the treatment. The secondary objective is to further investigate the efficacy of the drug.

Phase

5.27 miles

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Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome

We have previously reported that inherited mutations of TP53, which causes the premature cancer disorder Li-Fraumeni syndrome (LFS), can promote mitochondrial function both in patients and mouse models. In the course of our follow up studies, we encountered a LFS patient with a long-standing history of fatigue and muscle weakness ...

Phase

5.27 miles

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Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab Busulfan and TBI With Post-Transplant Cyclophosphamide

Allogeneic transplant using human leukocyte antigen (HLA) matched donors, both related and unrelated, has proven curative for patients with various immunodeficiencies, including those with ongoing infections. However, donor availability remains a limiting factor in the application of this treatment modality. For this protocol, a haploidentical donor is a related donor ...

Phase N/A

5.27 miles

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Sunitinib in Sarcomas of the Central Nervous System

Background Gliosarcoma and primary CNS sarcomas are malignant brain tumors uniformly associated with poor outcome. There are no known effective medical therapies for these cancers. Sunitinib is an orally administered small molecule that inhibits signaling of multiple receptor tyrosine kinases including those known to be activated in CNS sarcomas. Objectives ...

Phase

5.27 miles

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Immunotherapy With E7 T Cell Receptor T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions

Background Vulvar high-grade squamous intraepithelial lesion (HSIL) is a premalignant epithelial lesion that is frequently multifocal and/or recurrent. The primary treatment is surgery, which may result in disfigurement and compromise of the urethra, anus, or clitoris. Recurrence after surgery is common and primarily treated with additional surgery. Vulvar HSIL is ...

Phase

5.27 miles

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