Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 104 clinical trials
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma

This study is being conducted to test the safety and efficacy of ramucirumab in combination with other chemotherapy in the treatment of relapsed, recurrent, or refractory synovial sarcoma (SS) in children and young adults. This trial is part of the CAMPFIRE master protocol which is a platform to accelerate the …

Children's National Medical Center
 (5.3 away) Contact site
  • 0 views
  • 28 Nov, 2020
  • +59 other locations
Phase 1/2 Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects With Chronic Graft Versus Host Disease (cGVHD)

Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects with Chronic Graft Versus Host Disease (cGVHD)

ibrutinib
cell transplantation
immunosuppression
Children's National Medical Center
 (5.4 away) Contact site
  • 47 views
  • 27 May, 2020
  • +49 other locations
Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab

This clinical trial is a Phase 1/2, open-label, sequential-group, dose-escalation and cohort expansion study to determine the safety and preliminary anti-tumor activity of FLX475 as monotherapy and in combination with pembrolizumab. The study will be conducted in 2 parts, a dose-escalation phase (Part 1) and a cohort expansion phase (Part …

squamous cell carcinoma
breast cancer
lung cancer
carcinoma
lymphoma
Georgetown - Lombardi Comprehensive Cancer Center
 (7.9 away) Contact site
  • 50 views
  • 29 Nov, 2020
  • +30 other locations
Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection

Background Some people who get head and neck cancer will need surgery to treat their cancer. Research suggests that immunotherapy drugs may help fight head and neck cancer if given before surgery. In most cases, there is enough time between cancer diagnosis and surgery to test immunotherapy drugs. In this …

neck cancer
ct scan
squamous cell carcinoma
head and neck cancer
cancer
National Institutes of Health Clinical Center
 (9.4 away) Contact site
  • 0 views
  • 02 Nov, 2020
  • 1 location
Single Escalating Dose Pilot Trial of Canakinumab (ILARIS ) in Duchenne Muscular Dystrophy

Canakinumab is an anti-interleukin 1 beta (IL1) antibody approved for use in young children with familial Mediterranean fever, systemic onset juvenile idiopathic arthritis and TNF-receptor associated periodic fever syndrome. This study is a pilot trial to investigate the effects of canakinumab on clinical safety and potential clinical efficacy as demonstrated …

muscular dystrophy
glucocorticoids
Children's National Medical Center
 (5.4 away) Contact site
  • 20 views
  • 12 May, 2019
  • 1 location
A Study of APG-115 in Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Part 1 is a phase Ib standard "3 + 3" design will be employed to determine the MTD of APG-115 by assessing the DLT of APG-115 in combination with pembrolizumab. Part 2 is a Simon two-stage phase II study design. At RP2D of APG-115 in combination with pembrolizumab, approximately 43 …

Childrens National Research Institute
 (6.0 away) Contact site
  • 33 views
  • 13 Aug, 2020
  • +11 other locations
TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer

This is a multi-institutional pilot trial for patients with advanced breast cancer. The trial is designed to assess the safety and tolerability of induction talazoparib followed by combination of talazoparib and avelumab. As an exploratory endpoint, the study team will evaluate the immunomodulatory effects of induction talazoparib followed by the …

advanced breast cancer
measurable disease
MedStar Georgetown University Hospital
 (7.9 away) Contact site
  • 32 views
  • 10 Sep, 2020
  • +1 other locations
Phase I Nab-Paclitaxel Plus Gemcitabine With Proton Therapy for Locally Advanced Pancreatic Cancer (LAPC)

The purpose of this study is to determine the maximum tolerated dose of the chemotherapy drugs nab-paclitaxel and gemcitabine when combined with hypofractionated ablative proton therapy for the treatment of locally advanced pancreatic cancer. You will receive proton therapy once a day (Monday - Friday) for 3 weeks. Participants will …

MedStar Georgetown University Hospital
 (7.8 away) Contact site
  • 3 views
  • 01 Jul, 2020
  • +2 other locations
Poly-ICLC (Hiltonol) and Anti-PD1 or Anti-PD-L1

This is an open labeled, non-randomized adaptive pilot study. The study interventions involved in this study are: Poly-ICLC (Polyinosinic-Polycytidylic acid stabilized with polylysine and carboxymethylcellulose, also known as Hiltonol) treatment in combination with anti-PD-1 (Nivolumab, Cemiplimab or Pembrolizumab) or anti-PD-L1 (Atezolizumab or Durvalumab)

Chevy Chase RCCA
 (8.1 away) Contact site
  • 78 views
  • 04 Nov, 2019
  • +2 other locations
Addition of SNS-301 to Ongoing Checkpoint Inhibitor Treatment in Metastatic/Recurrent SCCHN

To evaluate safety, immunogenicity and anti-tumor responses of intradermally delivered SNS-301 added to ongoing checkpoint inhibitor therapy in locally advanced unresectable or metastatic/recurrent squamous cell carcinoma of the head and neck (SCCHN) patients.

head and neck carcinoma
squamous cell carcinoma
nivolumab
measurable disease
pembrolizumab
Georgetown University
 (5.8 away) Contact site
  • 19 views
  • 18 Oct, 2020
  • +10 other locations