Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 296 clinical trials
A Study of CMV Vaccine (HB-101) in Kidney Transplant Patients

HB-101 is a bivalent recombinant vaccine against human CMV infection. This is a randomized, placebo-controlled, phase 2 study to assess the safety, reactogenicity, immunogenicity, and efficacy of HB-101 in CMV-Seronegative patients receiving a kidney transplant from a CMV-Seropositive living donor and CMV-Seropositive patients.Patients enrolled should have a living donor kidney …

kidney transplant
Georgetown University Medical Center
 (7.9 away) Contact site
  • 28 Oct, 2020
  • +40 other locations
Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG

The purpose of this study is to investigate the activity of dabrafenib in combination with trametinib in children and adolescent patients with BRAF V600 mutation positive low grade glioma or relapsed or refractory high grade glioma.

measurable disease
malignant glioma
progressive disease
Children s National Hospital
 (5.4 away) Contact site
  • 26 Oct, 2020
  • +79 other locations
A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study

The purpose of this study is to collect long term safety data in subjects who are continuing to derive clinical benefit from treatment with Enzalutamide from the subjects participation in an enzalutamide clinical study sponsored by Astellas or Medivation (i.e., parent study) which has completed, at a minimum, the primary …

androgen suppression
Site US10050
 (7.0 away) Contact site
  • 01 Jan, 2021
  • +130 other locations
Study of Efficacy and Safety of Novel Spartalizumab Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

The primary purpose of this study is to evaluate the efficacy of novel spartalizumab (PDR001) combinations in previously treated unresectable or metastatic melanoma

measurable disease
systemic therapy
cytotoxic t-lymphocyte antigen 4
metastatic melanoma
Georgetown University/Lombardi Cancer Center CERL080AUS67
 (7.9 away) Contact site
  • 15 Jan, 2021
  • +31 other locations
Study of Dose Confirmation and Safety of Crizanlizumab in Pediatric Sickle Cell Disease Patients

The purpose of the Phase 2 CSEG101B2201 study is to confirm and to establish appropriate dosing and to evaluate the safety in pediatric participants ages 6 months to <18 years with a history of VOC with or without HU/HC, receiving crizanlizumab for 2 years. The efficacy and safety of crizanlizumab …

absolute neutrophil count
Children s National Hospital
 (5.3 away) Contact site
  • 31 Dec, 2020
  • +82 other locations
A Study to Assess the Antitumor Activity Safety Pharmacokinetics and Biomarkers of Zolbetuximab (IMAB362) in Participants With Claudin (CLDN) 18.2 Positive Metastatic or Advanced Unresectable Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma

The purpose of this study is to determine the Objective Response Rate (ORR) of zolbetuzimab as a single agent as assessed by an independent central reader. This study will also assess the ORR and Progression Free Survival (PFS) of zolbetuximab in combination with mFOLFOX6 and in combination with pembrolizumab, assess …

neutrophil count
adjuvant chemotherapy
Georgetown Univ Hospital
 (7.9 away) Contact site
  • 13 Dec, 2020
  • +22 other locations
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL LN-144 (Lifileucel)/LN-145 in combination with pembrolizumab or TIL LN-145/LN-145-S1 as a single therapy.

measurable disease
lung cancer
metastatic squamous cell carcinoma
stage iv non-small cell lung cancer
systemic therapy
Georgetown University Medical Center
 (7.8 away) Contact site
  • 16 Sep, 2020
  • +38 other locations
A Study of INCB050465 in Participants With Autoimmune Hemolytic Anemia

The purpose of this study is to evaluate the safety and efficacy of parsaclisib administered orally to participants with autoimmune hemolytic anemia (AIHA) who have decreased hemoglobin and evidence of ongoing hemolysis that requires treatment intervention.

Georgetown University Hospital
 (7.8 away) Contact site
  • 14 Oct, 2020
  • +24 other locations
CANTATA: CB-839 With Cabozantinib vs. Cabozantinib With Placebo in Patients With Metastatic Renal Cell Carcinoma

This clinical trial is a randomized Phase 2 evaluation of CB-839 (telaglenastat) in combination with cabozantinib versus placebo with cabozantinib in patients with advanced or metastatic Renal Cell Carcinoma with a clear cell component.

measurable disease
vascular endothelial growth factor
Georgetown University Medical Center
 (7.9 away) Contact site
  • 18 Aug, 2019
  • +138 other locations
PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0706

The study is conducted to evaluate the efficacy, safety and tolerability of two doses of K0706 compared to placebo in subjects with early Parkinson's Disease who are not receiving dopaminergic therapy.

early parkinson's
SPARC Site 26
 (7.9 away) Contact site
  • 04 Mar, 2020
  • +46 other locations