Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 146 clinical trials
A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma

The purpose of this study is to evaluate MEDI5752 in combination with axitinib.in subjects with advanced renal cell carcinoma.

Research Site
 (7.8 away) Contact site
  • 5 views
  • 05 Nov, 2020
  • +16 other locations
Experimental Infection of Hookworm-na ve Adults With Dermally-applied Infectious Necator Americanus Hookworm Larvae

An experimental hookworm infection model is being developed to provide early proof-of-concept that a hookworm vaccine targeting the blood-feeding pathway of adult hookworms is feasible and efficacious. The proposed model consists of vaccinating healthy, hookworm-nave adults with a candidate hookworm vaccine, followed by challenging them with the investigational product, Necator …

George Washington University Medical Faculty Associates
 (7.1 away) Contact site
  • 86 views
  • 10 Feb, 2020
  • 1 location
Phase 1 Safety Study of ACT-PFK-158 2HCl in Patients With Advanced Solid Malignancies

ACT-PFK-158 is a novel anti-cancer agent that inhibits glucose uptake in cancer cells. The primary objective of the study will be to determine the maximum tolerated dose (MTD) and to describe any dose limiting toxicity. The secondary objectives of the study will be to determine the safety profile of the …

solid neoplasm
metastasis
renal function test
neutrophil count
platelet count
Lombardi Comprehensive Cancer Center, Georgetown University
 (7.9 away) Contact site
  • 13 views
  • 07 Nov, 2020
  • +2 other locations
Nicotinic Receptor Genetic Variation and Alcohol Reward

Background People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this. They will focus on a nicotine receptor gene that may increase a person s AUD risk. Objectives To see …

National Institutes of Health Clinical Center
 (9.4 away) Contact site
  • 9 views
  • 23 Nov, 2020
  • 1 location
A Single-blind Study to Evaluate the Safety Tolerability and Immunogenicity of a Hantaan Puumala Virus DNA Vaccine

This is a single-center, randomized, single-blinded study of the Hantaan virus HTNV DNA vaccine alone, Puumala virus PUUV DNA vaccine alone, and mixed Hantaan/Puumala HTNV/PUUV DNA vaccines delivered intramuscularly IM by the needle-free PharmaJet Stratus DSJI device.

WRAIR Clinical Trials Center
 (6.2 away) Contact site
  • 17 views
  • 02 Mar, 2020
  • 1 location
Research Study Utilizing Expanded Multi-antigen Specific Lymphocytes for the Treatment of Solid Tumors

Patients with high-risk solid tumors, those that are refractory to standard up front therapy or relapse after completion of therapy, have a very poor prognosis despite attempts to induce remission with salvage regimen. Novel therapies are critical for this patient population with high-risk cancer. The ability of tumors to be …

conventional therapy
lymphoma
sarcoma
cancer
Children's National Medical Center
 (5.4 away) Contact site
  • 0 views
  • 08 Nov, 2020
  • 1 location
Computer-Assisted Self-Administration of Ethanol

This study will test the reliability of a procedure for self-administering ethanol (alcohol) intravenously (through a vein), using a computer-assisted method. People ordinarily self-administer alcohol through drinking alcoholic beverages, but blood alcohol levels resulting from drinking vary greatly among individuals. For research on alcohol dependence and treatment, a tool for …

National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 5 views
  • 24 Sep, 2020
  • 1 location
ABI-009 an mTOR Inhibitor for Patients With Severe Pulmonary Arterial Hypertension

mTOR activation has been shown to be relevant in the development and progression of pulmonary hypertension. Inhibition of mTOR has been shown to reverse or regress pulmonary hypertension in animal models. ABI-009 is an albumin-bound mTOR inhibitor with improved penetration in lung tissue.

primary pulmonary hypertension
pulmonary arterial hypertension
congenital heart defects
pulmonary function test
left ventricular end-diastolic pressure
National Institutes of Health
 (9.7 away) Contact site
  • 0 views
  • 15 Dec, 2019
  • +5 other locations
TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

Ewing sarcoma is characterized by genomic rearrangements resulting in over-expression of ets family transcription factors driving tumor progression. TK216 is designed to inhibit this effect by inhibiting downstream effects of the EWS-FLI1 transcription factor. This study is a first in human study of TK216 in subjects with Ewing sarcoma. The …

refractory ewing sarcoma
vincristine
Children's National Hospital
 (5.3 away) Contact site
  • 0 views
  • 21 Sep, 2020
  • +8 other locations
Technical Development of Cardiovascular Magnetic Resonance Imaging

The goal of this study is to develop advances in cardiovascular diagnostic and treatment methods using magnetic resonance imaging (MRI), a test that uses a strong magnetic field and radio waves to show anatomic detail. For the scan, the patient lies on a table in a cylinder containing a magnetic …

arteriopathy
angiography
atherosclerosis
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 13 views
  • 07 Nov, 2020
  • 1 location