Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 103 clinical trials
Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine M7824 ALT-803 and Epacadostat (QuEST1)

Background Immunotherapy drugs help the body to fight cancer. Scientists think that combining some of these drugs will make them work better than when used alone. This may be true for many types of cancer, including castration-resistant prostate cancer (CRPC). Objective To test if the combination of the drugs BN-brachyury, …

cancer
androgen ablation
bilateral orchidectomy
orchiectomy
metastasis
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 18 views
  • 25 Nov, 2020
  • 1 location
Functional Connectivity as a Biomarker of rTMS

Background Traumatic brain injury (TBI) damages the connections between brain cells. This can lead to problems like memory loss. Repetitive transcranial magnetic stimulation (rTMS) can help improve connections between brain areas in healthy people. Researchers want to see if it can be useful in patients with memory problems after TBI. …

memory impairment
amnesia
transcranial magnetic stimulation
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 52 views
  • 02 Jul, 2020
  • 1 location
H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

This is 3-arm, multicenter study that will be conducted through the Pacific Pediatric Neuro-oncology Consortium (PNOC). This study will assess the safety and immune activity of a synthetic peptide vaccine specific for the H3.3.K27M epitope given in combination with poly-ICLC and the H3.3.K27M epitope given in combination with poly-ICLC and …

diffuse intrinsic pontine glioma
glomerular filtration rate
blood transfusion
poly iclc
temozolomide
Children's National Medical Center
 (5.4 away) Contact site
  • 92 views
  • 03 Sep, 2020
  • +12 other locations
Effect of Exercise Training on Physical Cognitive and Behavioral Function in People With TBI

Background Traumatic brain injury (TBI) often causes problems with moving and balance, and thinking and emotions. Exercise can improve these things in people with other brain damage. Researchers want to look at the effect of exercise on these things in people with TBI. Objectives To study how head injuries affect …

head injury
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 87 views
  • 18 Oct, 2020
  • 1 location
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective To see if a new transplant regime is effective, safe and well …

x-rays
blood test
campath
cyclophosphamide
sirolimus
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 2 views
  • 11 Jun, 2020
  • 1 location
Lenalidomide Combined With Modified DA-EPOCH and Rituximab (EPOCH-R2) in Primary Effusion Lymphoma or KSHV-associated Large Cell Lymphoma

Background Primary effusion lymphoma (PEL) is a rare disease with no standard treatment. Researchers want to see if a drug called lenalidomide along with common chemotherapy drugs may be effective in treating PEL. Objective To test a new treatment for PEL. Eligibility People ages 18 and older with PEL. Design …

vincristine
prednisone
doxorubicin
cyclophosphamide
methotrexate
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 9 views
  • 20 May, 2020
  • 1 location
Study of Baricitinib a JAK1/2 Inhibitor in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Background Chronic graft versus host disease (cGVHD) can affect people who had a hematopoietic stem cell transplant using donor cells. It is often fatal. It is usually treated with high doses of steroids. But that helps only about half the people in the long term. Researchers want to see if …

cancer
prednisone
corticosteroids
urine test
second-line therapy
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 23 views
  • 04 Nov, 2020
  • 1 location
Alvelestat (MPH966) an Oral Neutrophil Elastase Inhibitor in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

Background Bronchiolitis obliterans syndrome (BOS) is a complication people can experience after hematopoietic stem cell transplant. It usually affects people with chronic graft versus host disease (cGVHD). This occurs when donor stem cells attack the cells of the person who received them. BOS reduces airflow and oxygen levels in the …

National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 35 views
  • 05 Nov, 2020
  • 1 location
Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

Background In a new cancer therapy, researchers take a person s blood, select a certain white blood cell to grow in the lab, and then change the genes of these cells using a virus. The cells are then given back to the person. This is called gene transfer. For this …

cancer
chemotherapy drug
immunohistochemistry
aldesleukin
cyclophosphamide
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 68 views
  • 25 Nov, 2020
  • 1 location
A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

Background Many people experience fatigue as a side effect of their illnesses and treatments. There are no medicines to treat fatigue, but a drug called ketamine has reduced fatigue in depressed people. Researchers hope that ketamine, compared to a drug called midazolam, can reduce fatigue in people with illnesses. Objective …

cancer
midazolam
National Institutes of Health Clinical Center
 (9.4 away) Contact site
  • 0 views
  • 25 Nov, 2020
  • 1 location