Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 106 clinical trials
A Dose Escalation and Cohort Expansion Study of Subcutaneously-Administered Cytokine (ALKS 4230) as a Single Agent and in Combination With Anti-PD-1 Antibody (Pembrolizumab) in Subjects With Select Advanced or Metastatic Solid Tumors (ARTISTRY-2)

This study will characterize the safety and tolerability and identify the recommended Phase 2 dose (RP2D) of subcutaneous (SC) ALKS 4230 as monotherapy and in combination with pembrolizumab.

Alkermes Investigational Site
 (7.9 away) Contact site
  • 5 views
  • 31 Aug, 2020
  • +9 other locations
REGN5093 in Patients With MET-Altered Advanced Non-Small Cell Lung Cancer

The primary objective of the dose escalation (phase 1) part of the study is to assess the safety, tolerability, and pharmacokinetics (PK) of REGN5093 for determination of the maximum tolerated dose (MTD) and/or definition of the recommended phase 2 dose (RP2D) of REGN5093 in patients with MET-altered Non-small cell lung …

metastasis
solid tumour
measurable disease
Regeneron Research Facility
 (7.9 away) Contact site
  • 29 views
  • 19 Aug, 2020
  • +9 other locations
Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

This is a multi center, Phase I, Phase II and surgical study of the CX-4945 drug (silmitasertib sodium) for patients with recurrent SHH (Sonic Hedgehog) medulloblastoma

Children's National Medical Center
 (5.3 away) Contact site
  • 18 views
  • 28 Jun, 2020
  • +8 other locations
Anti-PD-L1/TGF-beta Trap (M7824) Alone and in Combination With TriAd Vaccine and N-803 for Resectable Head and Neck Squamous Cell Carcinoma Not Associated With Human Papillomavirus Infection

Background Some people who get head and neck cancer will need surgery to treat their cancer. Research suggests that immunotherapy drugs may help fight head and neck cancer if given before surgery. In most cases, there is enough time between cancer diagnosis and surgery to test immunotherapy drugs. In this …

head and neck cancer
oropharyngeal
ct scan
squamous cell carcinoma
neutrophil count
National Institutes of Health Clinical Center
 (9.4 away) Contact site
  • 0 views
  • 02 Nov, 2020
  • 1 location
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag

Background Diamond-Blackfan anemia (DBA) is treated with steroids. But some people cannot take steroids, or steroids don t work. Other patients must get blood transfusions regularly which are time consuming and can have significant side effects. The drug eltrombopag can increase red blood cells. Researchers want to see if it …

cell counts
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 1 views
  • 05 Dec, 2020
  • 1 location
Safety Tolerability Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients

This study is designed to investigate whether the use of copanlisib is safe, feasible and beneficial to pediatric patients with solid solid tumors or lymphoma that are recurrent or refractory to standard therapy.

Children's National Medical Center
 (5.3 away) Contact site
  • 15 views
  • 05 Dec, 2020
  • +18 other locations
Durvalumab and Tremelimumab for Pediatric Malignancies

The purpose of the study is to determine the recommended dose of durvalumab and tremelimumab (immunotherapy drugs) in pediatric patients with advanced solid and hematological cancers and expand in a second phase to test the efficacy of these drugs once this dose is determined.

acute leukemia
cancer
leukemia
lymphoma
durvalumab
Research Site
 (5.4 away) Contact site
  • 15 views
  • 02 Dec, 2020
  • +24 other locations
Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab

This clinical trial is a Phase 1/2, open-label, sequential-group, dose-escalation and cohort expansion study to determine the safety and preliminary anti-tumor activity of FLX475 as monotherapy and in combination with pembrolizumab. The study will be conducted in 2 parts, a dose-escalation phase (Part 1) and a cohort expansion phase (Part …

breast cancer
carcinoma
lymphoma
gastric cancer
metastasis
Georgetown - Lombardi Comprehensive Cancer Center
 (7.9 away) Contact site
  • 50 views
  • 05 Dec, 2020
  • +30 other locations
Safety and Effectiveness of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML) a Cancer of the Blood

Quizartinib is an experimental drug. It is not approved for regular use. It can only be used in medical research. Children or young adults with a certain kind of blood cancer (FLT3-ITD AML) might be able to join this study if it has come back after remission or is not …

hematologic malignancy
cytarabine
consolidation therapy
remission
methotrexate
Children's National Medical Center
 (5.4 away) Contact site
  • 39 views
  • 11 Nov, 2020
  • +30 other locations
A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK ROS1 or NTRK1-3 Rearrangements

Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with advanced solid malignancies harboring an ALK, ROS1, NTRK1, NTRK2, or NTRK3 gene rearrangement. Midazolam DDI substudy …

cancer
ROS1
solid tumor
Georgetown Lombardi Comprehensive Cancer Center PHASE 2
 (7.9 away) Contact site
  • 338 views
  • 12 Oct, 2020
  • +124 other locations