Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 240 clinical trials
Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

This randomized phase III trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). Mutations, or changes, in ALK can make it very active and important …

neutrophil count
ct scan
cardiac arrhythmia
biomarker analysis
Sibley Memorial Hospital
 (8.2 away) Contact site
  • 28 May, 2020
  • +1089 other locations
Assessment of Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)

The purpose of this study is to evaluate the efficacy and safety of ruxolitinib in the treatment of participants with COVID-19-associated Acute Respiratory Distress Syndrome (ARDS) who require mechanical ventilation.

mechanical ventilation
coronavirus infection
respiratory distress
Georgetown University Hospital
 (7.8 away) Contact site
  • 25 Dec, 2020
  • +37 other locations
A Study to Assess AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis (Formerly Referred to as Eosinophilic Gastroenteritis)

This is a Phase 3, multi-center, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of lirentelimab (AK002), given monthly for 6 doses, in patients with moderately to severely active Eosinophilic Gastritis and/or Eosinophilic Duodenitis (formerly referred to as Eosinophilic Gastroenteritis) who have an inadequate response with, lost response …

Allakos Investigational Site
 (8.1 away) Contact site
  • 26 Dec, 2020
  • +53 other locations
Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure

This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. Approximately 200 patients will be enrolled from approximately 200 centers in North America, …

postoperative hemorrhage
coronary artery bypass graft
packed red blood cells
MedStar Health Research Institute
 (5.4 away) Contact site
  • 11 Oct, 2020
  • +7 other locations
Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian or Primary Peritoneal Cancer

This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the body which in turn may stop the …

primary peritoneal carcinoma
neutrophil count
residual tumor
Sibley Memorial Hospital
 (8.2 away) Contact site
  • 18 Nov, 2019
  • +219 other locations
The Safety and Efficacy of a Tumor Necrosis Factor Receptor Fusion Protein on Uveitis Associated With Juvenile Rheumatoid Arthritis

This study will investigate the safety and effectiveness of the drug Enbrel (TNFR:Fc) to treat uveitis (eye inflammation) in patients with juvenile rheumatoid arthritis.

fusion protein
eye inflammation
anterior uveitis
National Institutes of Health
 (9.7 away) Contact site
  • 07 Nov, 2020
  • 1 location
Use of Acthar in Patients With FSGS That Will be Undergoing Renal Transplantation

This study will evaluate the use of Acthar in patients to undergo renal transplantation and will measure the rate of FSGS recurrence.

kidney transplant
Medstar Georgetown Transplant Institute
 (6.0 away) Contact site
  • 23 Dec, 2020
  • 1 location
Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer

This phase III trial studies how well chemotherapy and radiation therapy work with or without atezolizumab in treating patients with localized muscle invasive bladder cancer. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as gemcitabine, cisplatin, fluorouracil and mitomycin-C, work in different …

bladder cancer
gilbert's syndrome
systemic therapy
Sibley Memorial Hospital
 (8.1 away) Contact site
  • 14 Jan, 2021
  • +137 other locations
A Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Participants With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant

The purpose of this study is to evaluate conversion rate to minimal residual disease (MRD) negativity following the addition of daratumumab to lenalidomide relative to lenalidomide alone, when administered as maintenance treatment to anti-cluster of differentiation 38 (CD38) treatment naive participants with newly diagnosed multiple myeloma who are MRD positive …

cell transplantation
progressive disease
bone marrow procedure
MedStar Georgetown University Hospital
 (7.9 away) Contact site
  • 20 Nov, 2020
  • +69 other locations
Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy

Background Partial lipodystrophy can cause high blood fat levels and resistance to insulin. This can lead to health problems including diabetes. Researchers have found that the drug metreleptin improves health in people with this disease. Objective To test the safety and effectiveness of metreleptin. Eligibility People age 6 months and …

hemoglobin a1c
oral glucose tolerance test
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 10 Nov, 2019
  • 1 location