Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 145 clinical trials
A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma

The purpose of this study is to evaluate MEDI5752 in combination with axitinib.in subjects with advanced renal cell carcinoma.

Research Site
 (7.8 away) Contact site
  • 5 views
  • 05 Nov, 2020
  • +16 other locations
TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

Ewing sarcoma is characterized by genomic rearrangements resulting in over-expression of ets family transcription factors driving tumor progression. TK216 is designed to inhibit this effect by inhibiting downstream effects of the EWS-FLI1 transcription factor. This study is a first in human study of TK216 in subjects with Ewing sarcoma. The …

vincristine
refractory ewing sarcoma
Children's National Hospital
 (5.3 away) Contact site
  • 0 views
  • 02 Dec, 2020
  • +8 other locations
Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

Background Dopamine (DA) is a chemical signal in the brain linked to learning, memory, and habits. Stimulant drugs like methylphenidate can increase DA in the brain. Researchers want to measure DA with and without this drug. They want to learn how methylphenidate and brain dopamine affect body responses, mood, and …

National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 0 views
  • 15 Oct, 2020
  • 1 location
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

Background Glioblastoma (GBM) brain tumors almost always return after treatment. When that happens the tumor can never completely be removed by surgery, so most people also receive drugs. Researchers want to see if combining the drugs nivolumab and BMS-986016 may help. Objectives To study how nivolumab affects the brain s …

MRI
brain tumor
recurrent glioblastoma
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 19 views
  • 18 Oct, 2020
  • 1 location
Nicotinic Receptor Genetic Variation and Alcohol Reward

Background People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this. They will focus on a nicotine receptor gene that may increase a person s AUD risk. Objectives To see …

National Institutes of Health Clinical Center
 (9.4 away) Contact site
  • 9 views
  • 23 Nov, 2020
  • 1 location
Research Study Utilizing Expanded Multi-antigen Specific Lymphocytes for the Treatment of Solid Tumors

Patients with high-risk solid tumors, those that are refractory to standard up front therapy or relapse after completion of therapy, have a very poor prognosis despite attempts to induce remission with salvage regimen. Novel therapies are critical for this patient population with high-risk cancer. The ability of tumors to be …

sarcoma
lymphoma
conventional therapy
cancer
Children's National Medical Center
 (5.4 away) Contact site
  • 0 views
  • 08 Nov, 2020
  • 1 location
Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids

Background The immune system defends the body against bacteria and other harmful invaders. But it can overact and attack healthy cells by mistake. The group of drugs called glucocorticoids (GCs) can calm down an overactive immune system. But they often cause negative side effects. Researchers want to learn how human …

National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 0 views
  • 25 Oct, 2020
  • 1 location
Phase 1 Safety Study of ACT-PFK-158 2HCl in Patients With Advanced Solid Malignancies

ACT-PFK-158 is a novel anti-cancer agent that inhibits glucose uptake in cancer cells. The primary objective of the study will be to determine the maximum tolerated dose (MTD) and to describe any dose limiting toxicity. The secondary objectives of the study will be to determine the safety profile of the …

solid neoplasm
renal function test
metastasis
platelet count
neutrophil count
Lombardi Comprehensive Cancer Center, Georgetown University
 (7.9 away) Contact site
  • 13 views
  • 07 Nov, 2020
  • +2 other locations
Computer-Assisted Self-Administration of Ethanol

This study will test the reliability of a procedure for self-administering ethanol (alcohol) intravenously (through a vein), using a computer-assisted method. People ordinarily self-administer alcohol through drinking alcoholic beverages, but blood alcohol levels resulting from drinking vary greatly among individuals. For research on alcohol dependence and treatment, a tool for …

National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 5 views
  • 24 Sep, 2020
  • 1 location
ABI-009 an mTOR Inhibitor for Patients With Severe Pulmonary Arterial Hypertension

mTOR activation has been shown to be relevant in the development and progression of pulmonary hypertension. Inhibition of mTOR has been shown to reverse or regress pulmonary hypertension in animal models. ABI-009 is an albumin-bound mTOR inhibitor with improved penetration in lung tissue.

left ventricular end-diastolic pressure
primary pulmonary hypertension
pulmonary arterial hypertension
pulmonary function test
congenital heart defects
National Institutes of Health
 (9.7 away) Contact site
  • 0 views
  • 15 Dec, 2019
  • +5 other locations