Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 142 clinical trials
Pevonedistat Irinotecan and Temozolomide in Treating Patients With Recurrent or Refractory Solid Tumors or Lymphoma

This phase I trial studies the side effects and best dose of pevonedistat when given together with irinotecan hydrochloride and temozolomide in treating patients with solid tumors, central nervous system (CNS) tumors, or lymphoma that have come back after a period of improvement (recurrent) or that do not respond to …

seizure disorder
neutrophil count
cytotoxic chemotherapy
iobenguane
cns tumors
Children's National Medical Center
 (5.4 away) Contact site
  • 8 views
  • 03 Dec, 2020
  • +17 other locations
Multi-institutional Prospective Research of Expanded Multi-antigen Specifically Oriented Lymphocytes for the Treatment of VEry High Risk Hematopoietic Malignancies

This Phase I dose-escalation trial is designed to evaluate the safety of administering rapidly -generated tumor multi-antigen associated -specific cytotoxic T lymphocytes, to HSCT recipients (Arm A) or future HSCT recipients (Arm B) for the treatment of high-risk or relapsed or refractory hematopoietic malignancies. In addition to safety, this study …

Childrens National Medical Center
 (5.4 away) Contact site
  • 19 views
  • 19 Jul, 2020
  • +1 other locations
Haploidentical Hematopoietic Stem Cell Transplantation

The study is designed as a Pilot/Phase 1 trial of reduced intensity Haploidentical HSCT in patients with sickle cell disease and thalassemia. The purpose of the study is to assess the safety and toxicity of reduced intensity conditioning haploidentical hematopoietic stem cell transplantation.

cell transplantation
transfusion dependent thalassemia
iron overload
stroke
iron
Childrens National Medical Center
 (5.3 away) Contact site
  • 143 views
  • 20 Jul, 2020
  • 1 location
Combination Nilotinib and Paclitaxel in Adults With Relapsed Solid Tumors

Background Researchers want to find better ways to treat cancer. One drug that treats cancer is paclitaxel. Sometimes proteins block that drug from working. Researchers want to see if another drug, nilotinib, helps paclitaxel work better. Objective To test the safety of nilotinib plus paclitaxel and find out what doses …

advanced cancer
neutrophil count
paclitaxel
metastasis
nitrosoureas
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 0 views
  • 18 Dec, 2020
  • 1 location
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Background The Gigaxonin gene lets the body make a protein chemical called Gigaxonin. Nerves need Gigaxonin to work properly. Giant Axonal Neuropathy (GAN) causes a shortage of functional Gigaxonin. Nerves stop working normally in people with GAN. This causes problems with walking and sometimes with eating, breathing, and many other …

weakness
skin biopsy
MRI Scan
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 43 views
  • 27 Dec, 2020
  • 1 location
Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors

Background Researchers want to develop better ways to treat cancer. In this study, they will give people with cancer two drugs. These drugs have been used on their own to treat some blood cell cancers. Objectives To test the safety and efficacy of the drug combination of bortezomib and clofarabine. …

advanced cancer
neutrophil count
primary cancer
neuropathy
solid neoplasm
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 25 views
  • 17 Jan, 2021
  • 1 location
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Background A glioblastoma is a tumor in the brain. It is treated with surgery, chemotherapy and radiation therapy. However, most people s tumors come back after therapy. When the tumor grows back, surgery or chemotherapy may not be possible or may no longer work. Repeat radiation therapy or re-irradiation, is …

cytotoxic chemotherapy
temozolomide
gliosarcoma
glioblastoma multiforme
combined modality therapy
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 41 views
  • 15 Dec, 2020
  • 1 location
Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation

Background Drugs like nalmefene interfere with opioid receptors. This might reduce drinking. The gene OPRM1 determines opioid receptor functions. Researchers want to see if nalmefene affects people s responses to alcohol cues. They also want to compare how nalmefene affects people with different forms of OPRM1. Objectives To test nalmefene …

National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 9 views
  • 19 Jan, 2021
  • 1 location
Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies

Background One type of cancer therapy takes blood cells from a person, changes them in a lab, then gives the cells back to the person. In this study, researchers are using an anti-CD22 gene, a virus, and an immune receptor to change the cells. Objective To see if giving anti-CD22 …

cell transplantation
neutrophil count
chemotherapy drug
white blood cell count
blood cell count
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 31 views
  • 24 Dec, 2020
  • 1 location
Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma

Background Kaposi sarcoma (KS) is a cancer most often seen in people with HIV. It causes lesions. These are usually on the skin but sometimes in the lymph nodes, lungs, and gastrointestinal tract. Researchers think a combination of drugs may help treat KS. Objective To test a combination of the …

neutrophil count
cytotoxic chemotherapy
diastolic blood pressure
atazanavir
progressive disease
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 11 views
  • 01 Oct, 2020
  • 1 location