Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 147 clinical trials
HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Background Some people with Amyotrophic Lateral Sclerosis (ALS) have a high level of the virus HERV-K in their blood. Researchers do not think this virus causes ALS. But they don t know why some people with ALS have a high level of it. They want to know if HERV-K can …

riluzole
primary lateral sclerosis
edaravone
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 80 views
  • 25 Oct, 2020
  • 1 location
Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamic of Oral Anticoagulants (Rivaroxaban Apixaban) in Health Volunteers

Background Rivaroxaban and apixaban are blood thinners. People with HIV may need to take them to treat or prevent blood clots. The anti-HIV drug darunavir (DRV) can increase the amount of these blood thinners in the body. This can cause bleeding or other health problems. The drug cobicistat (COBI) is …

blood test
fasting
body mass index
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 6 views
  • 05 Nov, 2020
  • 1 location
QUILT-3.017: Study of NEO-201 in Solid Tumors

This is an open label, first-in-human, phase 1, dose escalation study to determine the safety including dose limiting toxicity (DLT) and maximal tolerated dose of the monoclonal antibody NEO-201 in adults with solid tumors (cancer) which has not responded to standard treatments.

pancreatic cancers
neuropathy
monoclonal antibodies
tyrosine
cancer
National Cancer Institute
 (9.7 away) Contact site
  • 40 views
  • 18 Aug, 2019
  • 1 location
Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)

AINV18P1 is a Phase 1 study where palbociclib will be administrated in combination with a standard re-induction platform in pediatric relapsed Acute Lymphoblastic Leukemia (ALL) and lymphoblastic lymphoma (LL). LL patients are included because the patient population is rare and these patients are most commonly treated with ALL regimens. The …

prednisone
pegaspargase
blood cell count
vincristine
prednisolone
Children's National Medical Center
 (5.4 away) Contact site
  • 16 views
  • 28 Oct, 2020
  • +18 other locations
Tumor Associated Antigen Specific T Cells (TAA-T) With PD1 Inhibitor for Lymphoma

This is a Phase I, open-label multi-site trial designed to evaluate the safety of administering rapidly-generated Tumor associated antigen specific T cells (TAA-T) with the Programmed Death1 (PD-1) inhibitor Nivolumab, in relapsed/refractory lymphoma (rel/ref) patients with measurable disease (group A) or as adjunctive therapy following autologous hematopoeitic stem cell transplant(HSCT) …

hodgkin's disease
b-cell lymphoma
pet/ct scan
lymphoma
salvage therapy
Children's National Medical Center
 (5.4 away) Contact site
  • 24 views
  • 19 Aug, 2020
  • +1 other locations
Interleukin-15 (IL-5) in Combination With Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies

Background Some T-cell lymphomas and leukemias do not respond to standard treatment. Researchers hope to develop a treatment that works better than current treatments. Objective To test if interleukin (IL-5) combined with avelumab is safe and effective for treating certain cancers. Eligibility People ages 18 and older with relapsed T-cell …

enteropathy
bone marrow procedure
adult t-cell leukemia
lymphoma
large cell lymphoma
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 18 views
  • 05 Dec, 2020
  • 1 location
PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel TSPO Radioligand

Background Aging-related progressive neurological disorders include frontotemporal dementia, Lou Gehrig s disease, and Alzheimer s disease. Little is known about what causes these disorders. Brain inflammation may be involved. Researchers want to see if scans using radioactive drugs can show brain inflammation. Objective To see if the drug [11C]ER176 can …

huntington's chorea
pick's disease
alzheimer's disease
frontotemporal lobar degeneration
pittsburgh compound b
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 10 views
  • 09 Jul, 2020
  • 1 location
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

This study will evaluate palbociclib in combination with chemotherapy (temozolomide with irinotecan and topotecan with cyclophosphamide) in children, adolescents and young adults with recurrent or refractory solid tumors. The main purpose of this study is to evaluate the safety of palbociclib in combination with chemotherapy in order to estimate the …

renal function
solid tumor
bone marrow procedure
alopecia
biological therapy
Children's National Medical Center
 (5.4 away) Contact site
  • 113 views
  • 05 Nov, 2020
  • +59 other locations
Epigenetic Reprogramming in Relapse/Refractory AML

This is a pilot study using decitabine and vorinostat before and during chemotherapy with fludarabine, cytarabine and G-CSF (FLAG).

hematopoietic growth factors
residual tumor
tacrolimus
remission
refractory acute myeloid leukemia (aml)
Children's National Medical Center
 (5.4 away) Contact site
  • 182 views
  • 08 Oct, 2020
  • +33 other locations
Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

This is a multi-institutional Phase I dose-escalation and dose-expansion trial for patients with advanced, solid tumor malignancies who have pre-identified deleterious germline or somatic mutations in the homologous recombination deoxyribonucleic acid (DNA) repair pathway (HR deficient). The trial is designed to assess the efficacy and safety of niraparib plus carboplatin …

renal function
solid tumor
neutrophil count
carboplatin
advanced solid tumor
Lombardi Comprehensive Cancer Center
 (5.8 away) Contact site
  • 7 views
  • 24 Feb, 2020
  • +1 other locations