Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 145 clinical trials
Pevonedistat Irinotecan and Temozolomide in Treating Patients With Recurrent or Refractory Solid Tumors or Lymphoma

This phase I trial studies the side effects and best dose of pevonedistat when given together with irinotecan hydrochloride and temozolomide in treating patients with solid tumors, central nervous system (CNS) tumors, or lymphoma that have come back after a period of improvement (recurrent) or that do not respond to …

stem cell infusion
metastasis
interferon
blood count
glomerular filtration rate
Children's National Medical Center
 (5.4 away) Contact site
  • 8 views
  • 25 Nov, 2020
  • +17 other locations
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

This study will examine the safety of giving the experimental drug, resiniferatoxin (RTX), to treat severe pain in patients with advanced cancer. RTX is a chemical extracted from a cactus-like plant. It is similar to capsaicin, the active ingredient in hot pepper. RTX has relieved pain and reduced the need …

neurological examinations
antidepressants
analgesics
administration of blood products
aspirin
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 326 views
  • 18 Oct, 2020
  • 1 location
Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation

Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a procedure that transplants bone marrow cells (stem cells) from a matching donor into a recipient in order to allow the donor stem cells to produce cells that will attack the recipient s cancer cells. AlloHSCT is performed when chemotherapy, immunotherapy, or …

cell transplantation
chemotherapy regimen
diffuse large b-cell lymphoma
high grade lymphoma
cancer chemotherapy
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 9 views
  • 25 Nov, 2020
  • +1 other locations
A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia

Patients with relapsed or refractory leukemia often develop resistance to chemotherapy and some patients who relapse following CD19 directed therapy relapse with CD19 negative leukemia. For this reason, the investigators are attempting to use T-cells obtained directly from the patient, which can be genetically modified to express two chimeric antigen …

leukemia
graft versus host disease
immunosuppressive agents
refractory leukemia
Children's National Medical Center
 (5.4 away) Contact site
  • 72 views
  • 03 Aug, 2020
  • +2 other locations
NHS-IL12 for Solid Tumors

Background The experimental drug NHS-IL12 may help the immune system become more active and kill cancer cells that have not responded to standard treatments. NHS-IL12 has been designed to cause less severe side effects than other anticancer drugs, and may be more effective. More research is needed to test NHS-IL12 …

ct scan
chemotherapy regimen
metastasis
cancer chemotherapy
cancer
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 2 views
  • 11 Nov, 2020
  • 1 location
HIV-1 Specific T -Cells (HST-NEETs) for HIV-Infected Individuals

This is a phase I, multi-site, study of the safety, immunologic and virologic responses of ex vivo expanded HIV-1 multi-antigen specific T-cell therapy (HST-NEET) as a therapeutic strategy in HIV-infected individuals suppressed on antiretroviral therapy (ART).

antiretroviral agents
enzyme-linked immunosorbent assay
protease
reverse transcriptase inhibitor
hiv-1 infection
Children's National Health System
 (5.4 away) Contact site
  • 18 views
  • 20 Jul, 2020
  • +2 other locations
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

Background Human immunodeficiency virus (HIV) is treated with antiretroviral drugs. Many people with HIV also have the lung infection tuberculosis (TB). Most TB treatments are complicated. A simpler treatment of two TB drugs can be taken once a week. Researchers want to study how the HIV and TB drugs affect …

blood test
vitamins
cervical cap
fasting
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 9 views
  • 17 Sep, 2020
  • 1 location
Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas

Background The new drug LMP744 damages DNA. This causes cell death. Researchers want to see if it can treat certain kinds of cancer. They want to understand how the drug works and how it affects the body. Objective To test the safety of LMP744 and find out the dose of …

chemotherapy regimen
anticancer agents
measurable disease
neutrophil count
cancer
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 44 views
  • 25 Nov, 2020
  • +1 other locations
A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors

This study is looking to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of lyso-thermosensitive liposomal doxorubicin (LTLD) administered in combination with MR-HIFU in children with relapsed/refractory solid tumors, which may include but are not limited to rhabdomyosarcoma and other soft tissue sarcomas, Ewing's sarcoma family …

cancer chemotherapy
monoclonal antibodies
colony stimulating factor
doxorubicin
sargramostim
Children's National Medical Center
 (5.4 away) Contact site
  • 50 views
  • 30 Sep, 2020
  • 1 location
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Background Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect. For most people, this lasts a week or less. Repeated doses of ketamine may help maintain this effect. Objective Main Study: To study …

anxiety
antidepressants
transcranial magnetic stimulation
major depressive disorder
depression
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 1858 views
  • 25 Nov, 2020
  • 1 location