Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 137 clinical trials
Recombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory Cancers

Background The drug IL-15 activates the immune system. The drugs nivolumab and ipilimumab unblock immune cells. The drugs together may allow immune cells to recognize and attack cancer cells, causing tumors to shrink. Objective To test the effects and maximum dose of IL-15, nivolumab, and ipilimumab. Eligibility People ages 18 …

National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 27 Apr, 2021
  • 1 location
The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females

Background Insomnia is associated with difficulty sleeping. The drug zolpidem is widely prescribed for insomnia. Women have reported worse effects from the drug than men. Women have higher amounts of zolpidem in their body that may persist after waking. Drug exposure may also depend on male hormones that change during …

definitive treatment
cancer treatment
National Institutes of Health Clinical Center
 (9.4 away) Contact site
  • 21 May, 2021
  • 1 location
A Single Dose of Pembrolizumab in HIV-Infected People

Background Human immunodeficiency virus (HIV) attacks the immune system. Some people with HIV have a low CD4+ T-cell count despite taking antiviral medicines that control HIV replication. These cells fight disease, so a low count makes it easier for people to become sick. Researchers want to see if a new …

antibody test
hormonal contraception
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 02 Apr, 2021
  • 1 location
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

Background Blood, tissue, and tumor cells contain genes. Genes are made up of DNA. DNA is the instruction book for each cell. In some people with cancer, the genes that might have slowed the growth of their tumor were turned off. Researchers want to see if a new drug can …

bone metastases
liver metastasis
tumor growth
primary cancer
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 13 Mar, 2021
  • 1 location
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Background Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Objective To …

clear cell renal cell carcinoma
platelet count
chemotherapy drugs
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 05 Apr, 2021
  • 1 location
Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas

It is believed that the body's immune system protects the body by attacking and killing tumor cells. T-lymphocytes (T-cells) are part of the immune system and can attack when they recognize special proteins on the surface of tumors. In most patients with advanced cancer, T-cells are not stimulated enough to …

malignant glioma
cellular therapy
neutrophil count
Children's National Hospital
 (5.4 away) Contact site
  • 16 Apr, 2021
  • +1 other locations
Durvalumab and Vicinium in Subjects With High-Grade Non-Muscle-Invasive Bladder Cancer Previously Treated With Bacillus Calmette-Guerin (BCG)

Background Non-muscle-invasive bladder cancer is in the early stages. But it usually comes back after treatment. The drugs Vicinium and Durvalumab may help the immune system find and destroy cancer cells. Objective To test if the drugs Durvalumab and Vicinium together are safe and effective to treat people with bladder …

transurethral resection
bladder tumor
luteinizing hormone
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 16 Jun, 2021
  • 1 location
Prostate SBRT for Locally Recurrent Prostate Cancer After Prior Radiotherapy

Background Prostate cancer is the second leading cause of cancer death in U.S. men. Radiation is an effective treatment for most patients with localized prostate cancer, but sometimes the tumor returns. Researchers want to see if a highly focused type of radiation can help. It is given in only 5 …

recurrent prostate cancer
pet/ct scan
prostate tumor
external beam radiation therapy
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 27 May, 2021
  • 1 location
PD-1 Inhibition to Determine CNS Reservoir of HIV-Infection

Background HIV affects millions of people. The disease may "hide" in the brain, even in people with well-controlled HIV without cancer. Then it may "wake up" and continue. The drug pembrolizumab uses the body s immune system to fight cells like cancer cells. It is approved to treat some cancers …

antiretroviral therapy
HIV Vaccine
immune globulin
antiretroviral agents
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 09 May, 2021
  • 1 location
CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies

Background B-cell leukemias and lymphomas are cancers that are often difficult to treat. The primary objective of this study is to determine the ability to take a patient's own cells (T lymphocytes) and grow them in the laboratory with the CD19/CD22-CAR receptor gene through a process called 'lentiviral transduction (also …

chemotherapy drug
kinase inhibitor
oxygen saturation
cell transplantation
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 01 May, 2021
  • 1 location