Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 145 clinical trials
Trial to Evaluate the Safety of Talimogene Laherparepvec Injected Into Tumors Alone and in Combination With Systemic Pembrolizumab MK-3475-611/Keynote-611

This is a phase 1b/2, multicenter, open-label, basket trial to evaluate the safety of talimogene laherparepvec injected intrahepatically into liver tumors alone and in combination with systemic IV administration of pembrolizumab, in subjects with non-HCC liver metastases from BC, CRC, gastroesophageal cancer (GEC), melanoma, NSCLC, RCC in Part 1 Group …

liver tumor
cancer
HER2
antiviral drugs
metastasis
Research Site
 (7.9 away) Contact site
  • 0 views
  • 20 Nov, 2020
  • +29 other locations
A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

This is a Phase I, open-label, dose escalation and dose expansion study with BID (suspension) and TID (tablet) oral dose of tazemetostat. Subjects will be screened for eligibility within 14 days of the planned first dose of tazemetostat. A treatment cycle will be 28 days. Response assessment will be evaluated …

Children's National Medical Center
 (5.4 away) Contact site
  • 0 views
  • 13 May, 2020
  • +35 other locations
Study of TSR-042 an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody in Participants With Advanced Solid Tumors

This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics …

solid tumor
bilateral oophorectomy
lymphoma
bevacizumab
endocrine therapy
GSK Investigational Site
 (7.8 away) Contact site
  • 0 views
  • 17 Jun, 2020
  • +186 other locations
First-in-human Study of BAY2287411 Injection a Thorium-227 Labeled Antibody-chelator Conjugate in Patients With Tumors Known to Express Mesothelin

The purpose of this study is to evaluate, in patients with tumors known to express the protein mesothelin, the following properties of BAY2287411 injection: safety (to identify, assess, minimize, and appropriately manage the risks associated to the study drug) tolerability (the degree to which side effects can be tolerated by …

National Cancer Institute
 (9.7 away) Contact site
  • 266 views
  • 20 Nov, 2020
  • +9 other locations
Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

The purpose of the study is to determine the maximum tolerated dose and assess the safety, tolerability and activity of carfilzomib, alone and in combination with induction chemotherapy, in children with relapsed or refractory acute lymphoblastic leukemia (ALL).

Research Site
 (5.4 away) Contact site
  • 125 views
  • 07 Oct, 2020
  • +78 other locations
A Study Exploring the Safety Tolerability Pharmacokinetics and Pharmacodynamics of INCB086550 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB086550 in participants with advanced solid tumors who have failed prior treatments.

solid tumor
monoclonal antibodies
Medstar Georgetown Medical Center, Inc
 (7.8 away) Contact site
  • 0 views
  • 12 Nov, 2020
  • +27 other locations
A Study to Evaluate the Safety Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With Human Immunodeficiency Virus (HIV)-1

This study will be conducted in two stages and will test the safety/tolerability, pharmacokinetics (how the body handles study drug) and pharmacodynamics (effects on the immune system and the virus) of the study drug ABBV-181 in HIV-1 infected participants undergoing ART interruption.

antiretroviral agents
drug test
body mass index
hiv-1 rna measurement
antiretroviral therapy
George Washington University Medical Faculty Associates /ID# 213893
 (7.0 away) Contact site
  • 147 views
  • 13 Sep, 2020
  • +22 other locations
Multi-institutional Prospective Research of Expanded Multi-antigen Specifically Oriented Lymphocytes for the Treatment of VEry High Risk Hematopoietic Malignancies

This Phase I dose-escalation trial is designed to evaluate the safety of administering rapidly -generated tumor multi-antigen associated -specific cytotoxic T lymphocytes, to HSCT recipients (Arm A) or future HSCT recipients (Arm B) for the treatment of high-risk or relapsed or refractory hematopoietic malignancies. In addition to safety, this study …

Childrens National Medical Center
 (5.4 away) Contact site
  • 19 views
  • 19 Jul, 2020
  • +1 other locations
Walking Therapy In Hemiparetic Stroke Patients Using Robotic-Assisted Treadmill Training

The overall goal of this study is to determine whether robotic-assisted gait training is better than standard physical therapy treatments for improving walking ability in hemiparetic stroke patients.

gait training
stroke
hemiparesis
other therapy
National Rehabilitation Hospital
 (5.4 away) Contact site
  • 19 views
  • 07 Nov, 2020
  • 1 location
Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal Neuropathy

Background The Gigaxonin gene lets the body make a protein chemical called Gigaxonin. Nerves need Gigaxonin to work properly. Giant Axonal Neuropathy (GAN) causes a shortage of functional Gigaxonin. Nerves stop working normally in people with GAN. This causes problems with walking and sometimes with eating, breathing, and many other …

skin biopsy
National Institutes of Health Clinical Center, 9000 Rockville Pike
 (9.7 away) Contact site
  • 43 views
  • 15 Oct, 2020
  • 1 location