Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 147 clinical trials
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

Background Glioblastoma (GBM) brain tumors almost always return after treatment. When that happens the tumor can never completely be removed by surgery, so most people also receive drugs. Researchers want to see if combining the drugs nivolumab and BMS-986016 may help. Objectives To study how nivolumab affects the brain s …

recurrent glioblastoma
brain tumor
MRI
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 19 views
  • 18 Oct, 2020
  • 1 location
A Trial For The Study of Falciparum Malaria Protein 013 Administered Via Intramuscular Injection in Healthy Adults

A Phase 1, open label clinical study to evaluate the safety, immunogenicity, tolerability and efficacy of Plasmodium falciparum Malaria Protein 013 (FMP013) combined with (ALF with QS-21), saponin molecule derived from the bark of Quillaja species (ALFQ)) in healthy adult volunteers at different doses and dosing schedules.

WRAIR, Clinical Trials Center
 (6.7 away) Contact site
  • 6 views
  • 29 Mar, 2020
  • 1 location
A Trial For The Study of Falciparum Malaria Protein 014 Administered Via Intramuscular Injection in Healthy Adults

A Phase 1, open label clinical study to evaluate the safety, immunogenicity, tolerability and efficacy of Plasmodium falciparum Malaria Protein 014 (FMP014) combined with (ALF with QS-21), saponin molecule derived from the bark of Quillaja species (ALFQ)) in healthy adult volunteers at different doses and dosing schedules.

Walter Reed Army Institute of Research
 (6.7 away) Contact site
  • 2 views
  • 30 Mar, 2020
  • 1 location
DS-1062a in Combination With Pembrolizumab in Advanced or Metastatic Non-Small Cell Lung Cancer Without Actionable Genomic Alterations (TROPION-Lung02)

This study will assess safety and treatment activity of DS-1062a in combination with pembrolizumab in participants with advanced or metastatic NSCLC without actionable genomic alterations who have had previously treated with platinum-based therapy with or without prior immunotherapy.

Johns Hopkins Kimmel Cancer Center
 (8.1 away) Contact site
  • 12 views
  • 05 Dec, 2020
  • +6 other locations
SARC037: A Phase I Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients

This study evaluates the trabectedin and irinotecan in the treatment of Ewings sarcoma, with a EWS-FLI1 mutation. Patients will also receive an infusion of 18F-FLT in combination with a Positron Emission Tomography (PET) scan to help evaluate the effect of treatment.

refractory ewing sarcoma
irinotecan
measurable disease
National Cancer Institute
 (9.4 away) Contact site
  • 0 views
  • 05 Oct, 2020
  • +2 other locations
Study of Proton Therapy in Adjuvant Pancreatic Cancer

This trial aims to determine a safe schedule of short-course proton beam radiation therapy with adjuvant mFOLFIRINOX for patients with resected pancreatic adenocarcinoma.

Georgetown University Medical Center - Lombardi Comprehensive Cancer Center
 (7.8 away) Contact site
  • 0 views
  • 12 Aug, 2020
  • 1 location
TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

Ewing sarcoma is characterized by genomic rearrangements resulting in over-expression of ets family transcription factors driving tumor progression. TK216 is designed to inhibit this effect by inhibiting downstream effects of the EWS-FLI1 transcription factor. This study is a first in human study of TK216 in subjects with Ewing sarcoma. The …

refractory ewing sarcoma
vincristine
Children's National Hospital
 (5.3 away) Contact site
  • 0 views
  • 05 Dec, 2020
  • +8 other locations
A Study Exploring the Safety Tolerability Pharmacokinetics and Pharmacodynamics of INCB086550 in Participants With Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics, pharmacodynamics, and early clinical activity of INCB086550 in participants with advanced solid tumors who have failed prior treatments.

solid tumor
monoclonal antibodies
Medstar Georgetown Medical Center, Inc
 (7.8 away) Contact site
  • 0 views
  • 12 Nov, 2020
  • +27 other locations
Study of TSR-042 an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody in Participants With Advanced Solid Tumors

This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics …

sarcoma
measurable disease
endocrine therapy
cancer chemotherapy
fluoropyrimidine
GSK Investigational Site
 (7.8 away) Contact site
  • 0 views
  • 17 Jun, 2020
  • +186 other locations
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging …

trastuzumab
MRI
metastasis
ejection fraction
breast cancer
Georgetown University Medical Center
 (7.9 away) Contact site
  • 79 views
  • 22 Oct, 2020
  • +25 other locations