Hyattsville, Maryland Clinical Trials

A listing of Hyattsville, Maryland clinical trials actively recruiting patient volunteers.

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Found 142 clinical trials
HERV-E TCR Transduced Autologous T Cells in People With Metastatic Clear Cell Renal Cell Carcinoma

Gene transfer is a new cancer therapy takes white blood cells from a person and grows them in a lab. The cells are changed with a virus to attack tumor cells, then returned to the person. Researchers want to see if this therapy fights kidney cancer cells. Metastatic renal cell …

clear cell renal cell carcinoma
clear cell carcinoma
primary cancer
renal cell cancer
National Heart, Lung, and Blood Institute (NHLBI)
 (9.7 away) Contact site
  • 22 Dec, 2020
  • 1 location
Caregiver-Provided Life Review for Persons with Dementia in Care Facilities

Five percent of community‐dwelling older Americans experience depression. The rate is higher among persons with dementia (PWD)(30%). One in 10 older adults (5.6 million) has Alzheimer’s dementia (2019) and 70% are cared for by their families. This public health issue will worsen as the aging baby boomers grow from 55 …

 (3.6 away) Contact site
  • 12 Jan, 2021
  • +252 other locations
A Study to Evaluate MEDI5752 and Axitinib in Subjects With Advanced Renal Cell Carcinoma

The purpose of this study is to evaluate MEDI5752 in combination with subjects with advanced renal cell carcinoma.

Research Site
 (7.8 away) Contact site
  • 17 Jan, 2021
  • +16 other locations
Nicotinic Receptor Genetic Variation and Alcohol Reward

Background People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this. They will focus on a nicotine receptor gene that may increase a person s AUD risk. Objectives To see …

National Institutes of Health Clinical Center
 (9.4 away) Contact site
  • 18 Jan, 2021
  • 1 location
Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

Background Dopamine (DA) is a chemical signal in the brain linked to learning, memory, and habits. Stimulant drugs like methylphenidate can increase DA in the brain. Researchers want to measure DA with and without this drug. They want to learn how methylphenidate and brain dopamine affect body responses, mood, and …

National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 15 Oct, 2020
  • 1 location
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

Background Glioblastoma (GBM) brain tumors almost always return after treatment. When that happens the tumor can never completely be removed by surgery, so most people also receive drugs. Researchers want to see if combining the drugs nivolumab and BMS-986016 may help. Objectives To study how nivolumab affects the brain s …

recurrent glioblastoma
brain tumor
National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 18 Oct, 2020
  • 1 location
Neoantigen DNA Vaccine in Combination With Nivolumab/Ipilimumab and PROSTVAC in Metastatic Hormone-Sensitive Prostate Cancer

This study study aims to elucidate the immune responses to a shared antigen vaccine (PROSTVAC) and tumor specific antigens generated DNA vaccine in combination with checkpoint blockade using nivolumab (anti-PD-1), and ipilimumab (anti-CTLA-4). Additionally, the investigators will study the impact of the combination immunotherapy on peripheral T cell activation, as …

National Cancer Institute (GU Malignancies Branch)
 (9.7 away) Contact site
  • 17 Jan, 2021
  • +1 other locations
A Single-blind Study to Evaluate the Safety Tolerability and Immunogenicity of a Hantaan Puumala Virus DNA Vaccine

This is a single-center, randomized, single-blinded study of the Hantaan virus HTNV DNA vaccine alone, Puumala virus PUUV DNA vaccine alone, and mixed Hantaan/Puumala HTNV/PUUV DNA vaccines delivered intramuscularly IM by the needle-free PharmaJet Stratus DSJI device.

WRAIR Clinical Trials Center
 (6.2 away) Contact site
  • 23 Jan, 2021
  • 1 location
Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids

Background The immune system defends the body against bacteria and other harmful invaders. But it can overact and attack healthy cells by mistake. The group of drugs called glucocorticoids (GCs) can calm down an overactive immune system. But they often cause negative side effects. Researchers want to learn how human …

National Institutes of Health Clinical Center
 (9.7 away) Contact site
  • 25 Oct, 2020
  • 1 location
Allogeneic Virus-specific T Cell Lines (VSTs)

The primary purpose of the study is to evaluate whether most closely HLA-matched multivirus-specific T cell lines obtained from a bank of allogeneic virus-specific T cell lines (VSTs) have antiviral activity against three viruses: EBV, CMV and adenovirus. Reconstitution of anti-viral immunity by donor-derived VSTs has shown promise in preventing …

Childrens National Medical Center
 (5.4 away) Contact site
  • 23 Jan, 2021
  • 1 location