E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 286 clinical trials
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168)

Primary Objective: To assess efficacy of daily SAR442168 compared to a daily dose of 14 mg teriflunomide (Aubagio) measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS Secondary Objective: To assess efficacy of SAR442168 compared to teriflunomide (Aubagio) on disability progression, MRI lesions, cognitive performance …

aubagio
brain lesion
hmr1726
teriflunomide
contraceptive use
Investigational Site Number 8400072
 (6.4 away) Contact site
  • 0 views
  • 10 Jun, 2021
  • +118 other locations
Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure

A Phase 3, 22-week, Multi-center, Randomized Withdrawal Study of ampreloxetine in Treating Symptomatic Neurogenic Orthostatic Hypotension in Subjects with Primary Autonomic Failure

Concord Hospital, Neurosciences Department
 (2.0 away) Contact site
  • 11 views
  • 23 May, 2021
  • +89 other locations
Safety and Diagnostic Efficacy of Mangoral in Patients With Focal Liver Lesions and Reduced Kidney Function

The overall objective of this study is to evaluate the safety and diagnostic efficacy of Mangoral in liver MRI in patients with known or suspected focal liver lesions and severe renal impairment. The diagnostic efficacy of Mangoral will be assessed in terms of visualization of detected focal liver lesions in …

Boston University
 (6.2 away) Contact site
  • 0 views
  • 22 May, 2021
  • +48 other locations
Multi-arm Optimization of Stroke Thrombolysis

The primary efficacy objective of the MOST trial is to determine if argatroban (100g/kg bolus followed by 3g/kg per minute for 12 hours) or eptifibatide (135g/kg bolus followed by 0.75g/kg/min infusion for two hours) results in improved 90-day modified Rankin scores (mRS) as compared with placebo in acute ischemic stroke …

Boston Medical Center
 (6.2 away) Contact site
  • 121 views
  • 25 Jan, 2021
  • +87 other locations
A Study of Heterologous Vaccine Regimen of Adenovirus Serotype 26 Mosaic4 Human Immunodeficiency Virus(Ad26.Mos4.HIV) Adjuvanted Clade C gp140 and Mosaic gp140 to Prevent HIV-1 Infection Among Cis-gender Men and Transgender Individuals Who Have Sex With Cis-gender Men and/or Transgender Individuals

The purpose of this study is to evaluate the vaccine efficacy (VE) of a heterologous vaccine regimen utilizing Ad26.Mos4.HIV and aluminum phosphate-adjuvanted Clade C gp140 and Mosaic gp140 for the prevention of HIV-1 infection in HIV-1 seronegative cis-gender men and transgender individuals having sex with cis-gender men and/or transgender individuals.

Dana-Farber/Brigham and Women's Hospital
 (5.2 away) Contact site
  • 74 views
  • 24 May, 2021
  • +78 other locations
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

This is a prospective, multicenter, open-label, randomized, controlled, parallel group, group-sequential, event-driven Phase 3 study to evaluate efficacy, safety and pharmacokinetics (PK) of macitentan in children.

connective tissue disease
heart disease
macitentan
hypertension
Boston Children's Hospital
 (5.2 away) Contact site
  • 172 views
  • 16 Jun, 2021
  • +106 other locations
Bezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001)

The primary objectives of this study are to evaluate the pharmacokinetics (PK), safety, and tolerability of bezlotoxumab in children aged 1 to <18 years of age with a confirmed diagnosis of Clostridium difficile infection (CDI) who are receiving antibacterial drug treatment. The primary hypothesis is that the area under the …

a 10
clostridium difficile
bezlotoxumab
Tufts Medical Center-Floating Hospital for Children ( Site 0046)
 (6.4 away) Contact site
  • 71 views
  • 12 Jun, 2021
  • +78 other locations
Efficacy and Safety APT-1011 in Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)

This is a 2-part randomized, double-blind, placebo-controlled study of APT-1011 in adults and adolescents (12 years) with EoE. Part A will evaluate the efficacy and safety of APT-1011 3 mg administered HS for the induction of response to treatment (histologic and symptomatic) over 12 weeks. Part B will evaluate histological …

dysphagia
esophagogastroduodenoscopy
Adare Pharmaceuticals
 (6.0 away) Contact site
  • 93 views
  • 14 Jun, 2021
  • +141 other locations
Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT

This is a Phase III randomized controlled trial of a passive ROM exercise program that will be performed in infants with HLHS and other single right ventricle anomalies following the Norwood procedure at PHN and Auxiliary Centers.

Boston Children's Hospital
 (5.2 away) Contact site
  • 0 views
  • 22 Apr, 2021
  • +8 other locations
A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)

The purpose of this study is to evaluate the safety and efficacy of ION373 in improving or stabilizing gross motor function across the full range of affected domains in patients with AxD.

IONIS Investigative Site
 (6.0 away) Contact site
  • 0 views
  • 16 Jun, 2021
  • +8 other locations