E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 291 clinical trials
Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase

The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S. aureus) bloodstream infections (BSI), including right-sided infective endocarditis (IE). Patients will be randomized to …

CF-301-105 Study Site
 (8.1 away) Contact site
  • 03 Aug, 2021
  • +46 other locations
Safety and Tolerability of Conversion From Oral Injectable or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients.

To assess safety and tolerability of patients converting from approved Relapsing Multiple Sclerosis (RMS) Disease Modifying Therapies (DMTs) to siponimod.

Novartis Investigative Site
 (6.6 away) Contact site
  • 20 Jun, 2021
  • +68 other locations
Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol

To determine if Alvimopan during open or robotic radical cystectomy with urinary diversion results in quicker return of bowel function (GI-2 recovery = time to upper [first toleration of solid food] and lower [first bowel movement] gastrointestinal recovery) compared to placebo.

ileal conduit
radical cystectomy
urinary diversion
Brigham and Women's Hospital
 (5.2 away) Contact site
  • 26 Jul, 2021
  • 1 location
A Study to Evaluate the Efficacy Safety and Drug Concentration of Certolizumab Pegol (CZP) in Children and Adolescent Study Participants With Moderate to Severe Chronic Plaque Psoriasis (PSO)

The purpose of the study is to demonstrate the efficacy and safety of certolizumab pegol in the treatment of moderate to severe chronic plaque psoriasis in study participants aged 6 to 11 and 12 to 17 years.

Ps0007 50158
 (2.0 away) Contact site
  • 17 Jun, 2021
  • +46 other locations
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)

The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters …

exchange transfusion
anti-thymocyte globulin
sickle hemoglobin
hemoglobin s
Boston Medical Center
 (6.2 away) Contact site
  • 31 Jul, 2021
  • +15 other locations
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder that can develop after a traumatic life experience that severely reduces quality of life. This multi-site, double-blind, placebo-controlled, randomized Phase 3 study will assess the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy compared to psychotherapy with placebo in participants diagnosed with …

psychiatric disorder
Trauma Research Foundation
 (3.6 away) Contact site
  • 28 Jun, 2021
  • +14 other locations
Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer

This trial studies how well atezolizumab added to the usual radiation therapy works in treating patients with stage I-IIA non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow …

ct scan
kidney function test
stereotactic body radiation therapy
neutrophil count
Lahey Hospital and Medical Center
 (8.1 away) Contact site
  • 04 Aug, 2021
  • +137 other locations
Evaluation of SARS-CoV-2 (COVID-19) Antibody-containing Plasma thErapy

In this study, investigators will determine whether the early addition of HT-CCP to standard treatment improves the clinical outcome (as assessed by the Modified WHO Ordinal Scale) of patients with COVID-19 who are hospitalized but not yet in moderate or severe ARDS.

acute respiratory distress
respiratory distress
Brigham and Women's Hospital
 (5.2 away) Contact site
  • 24 Jan, 2021
  • 1 location
A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy

This is a randomized, double-blind, placebo-controlled, multi-center study in the United States (U.S.) that will evaluate the effect of mavacamten treatment on reducing the number of septal reduction therapy (SRT) procedures performed in subjects with symptomatic obstructive hypertrophic cardiomyopathy (oHCM [also known as HOCM]) who are eligible for SRT based …

Brigham and Women's Hospital
 (4.5 away) Contact site
  • 18 Jun, 2021
  • +17 other locations
Stereotactic Body Radiation Therapy (SBRT) vs Trans-Arterial Chemoembolization (TACE) as Bridge to Transplant

This study will compare stereotactic body radiation therapy (SBRT) to trans-arterial chemoembolization (TACE) as a bridging strategy for patients with HCC undergoing liver transplantation. We propose that SBRT will be associated with longer time intervals between initial treatment and the need for retreatment, compared to TACE, as a "bridge" to …

liver transplant
stereotactic body radiation therapy
vascular invasion
Lahey Hospital & Medical Center
 (8.1 away) Contact site
  • 25 Jan, 2021
  • 1 location