E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 287 clinical trials
Relapsing Forms of Multiple Sclerosis (RMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168)

Primary Objective: To assess efficacy of daily SAR442168 compared to a daily dose of 14 mg teriflunomide (Aubagio) measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS Secondary Objective: To assess efficacy of SAR442168 compared to teriflunomide (Aubagio) on disability progression, MRI lesions, cognitive performance …

pregnancy test urine
aubagio
contraceptive use
hmr1726
teriflunomide
Investigational Site Number 8400072
 (6.4 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +120 other locations
Assess the Long Term Efficacy and Safety of Ruxolitinib Cream in Participants With Vitiligo

The purpose of this study is to evaluate the duration of response following withdrawal of ruxolitinib cream (Cohort A vehicle group), safety and maintenance of response with continued use of ruxolitinib cream in participants who have completed either Study NCT04052425 or NCT04057573 (parent studies) in which the participants will have …

Metro Boston Clinical Partners
 (2.0 away) Contact site
  • 176 views
  • 04 Jul, 2021
  • +83 other locations
A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease

This study will be conducted to evaluate the efficacy of lecanemab in participants with early Alzheimer's disease (EAD) by determining the superiority of lecanemab compared with placebo on the change from baseline in the Clinical Dementia Rating-Sum of Boxes (CDR-SB) at 18 months of treatment in the Core Study. This …

Partners Population Health
 (1.8 away) Contact site
  • 0 views
  • 29 Apr, 2021
  • +101 other locations
National Adaptive Trial for PTSD Related Insomnia

Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking medications called trazodone, eszopiclone, or gabapentin can help decrease symptoms of …

poor sleep
nightmares
gabapentin
anxiety
behavior therapy
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
 (5.4 away) Contact site
  • 10 views
  • 14 Jul, 2021
  • +34 other locations
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge

Lahey Hospital and Medical Center
 (8.1 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +74 other locations
A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis

Study CC-93538-EE-001 is a Phase 3, multicenter, multinational, randomized, double-blind, placebo-controlled induction and maintenance study to evaluate the efficacy and safety of CC- 93538 in adult and adolescent participants with eosinophilic esophagitis (EoE). The study will incorporate a 24-week Induction Phase followed by a 24-week Maintenance Phase. Participants will be …

Brigham and Women's Hospital
 (4.5 away) Contact site
  • 0 views
  • 02 May, 2021
  • +200 other locations
Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis

A Multicentre, Randomised, Double-Blind, Parallel-Group, Placebo-Controlled Phase 3 Efficacy and Safety Study of Tezepelumab in Participants with Severe Chronic Rhinosinusitis with Nasal Polyposis

Research Site
 (2.0 away) Contact site
  • 0 views
  • 24 Jul, 2021
  • +116 other locations
Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis

This is a phase 3 study designed to evaluate whether the administration of ganciclovir increases ventilator-free days in immunocompetent patients with sepsis associated acute respiratory failure. Our hypothesis is that IV ganciclovir administered early in critical illness will effectively suppress CMV reactivation in CMV seropositive adults with sepsis-associated acute respiratory …

Brigham & Women's Hospital
 (5.4 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +19 other locations
A Study of BIIB067 When Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation

The primary objective of this study is to evaluate the efficacy of BIIB067 when initiated in presymptomatic adult carriers of a superoxide dismutase 1 (SOD1) mutation with elevated neurofilament (NF). The secondary objectives of this study are to evaluate the safety and tolerability of BIIB067 and to evaluate the effect …

Research Site
 (2.0 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +6 other locations
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

This Phase 3 study will evaluate the efficacy and safety of KSI-301 compared to aflibercept, in participants with neovascular (wet) age-related macular degeneration (wAMD)

Ophthalmic Consultants of Boston
 (6.0 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +65 other locations