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E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

RESULTS

Found (725) clinical trials

The Effects of Nicotinamide Riboside Supplementation on NAD+/NADH Ratio and Bioenergetics

The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain NAD+/NADH ratio and bioenergetics functions in healthy individuals using phosphorus magnetic resonance spectroscopy (31P MRS) imaging. The secondary aim is to investigate the effects of NR on brain structure and neurotransmitter ...

Phase

1.78 miles

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Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression

In this study, the investigators will examine changes in brain activity from Low Field Magnetic Stimulation in subjects over the age of 50 with bipolar disorder who are currently depressed using functional Magnetic Resonance Imaging and proton Magnetic Resonance Spectroscopy. Following screening visits, study procedures include two visits, at least ...

Phase N/A

1.78 miles

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Neuroimaging Studies of Reward Processing in Depression

The overarching goals of this research are to investigate: (1) stress-induced glutamatergic abnormalities and their relation to disruption within the corticostriatal valuation circuit in MDD; (2) stress-induced DA signaling disruptions in MDD; and (3) the predictive validity of these two pathophysiological mechanisms. This will be achieved through an innovative integration ...

Phase N/A

1.78 miles

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Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients

By design, all subjects in the Intervention arm will start by being under treatment. During the course of follow-up, we expect that some will stay consistently on treatment, some will discontinue treatment (become non-adherent), while others will make transitions on and off treatment in various patterns. In contrast, by design, ...

Phase

1.78 miles

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Study of Treatment for Opioid Dependence and Anxiety Disorders

This Stage 1 behavioral treatment development trial involves two stages: manual development and pilot testing in an open trial, and a small randomized controlled trial. In both phases, opioid use and anxiety symptoms will be measured as the primary clinical outcome, along with measures of feasibility and patient satisfaction. These ...

Phase N/A

1.78 miles

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McLean and Genomind Prospective Study

Importance / Relevance: Psychiatric disorders are etiologically complex and clinically heterogeneous which makes them challenging to diagnose and effectively treat. Thus, they pose a huge societal burden and involve substantial costs in human and financial terms. Specifically in the U.S., mental health disorders including MDD and PTSD account for 6.2% ...

Phase N/A

1.78 miles

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Genetic and Neural Predictors of Adolescent Depression

This study aims to examine the relationship between mood and brain activity in adolescent girls in order to better understand the genetic and neural predictors of adolescent depression. The participants in this study will be healthy female adolescents aged 12-14 and their mothers. They will participate for a total of ...

Phase N/A

1.78 miles

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Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease (AD) (THC-AD)

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of aging, affecting an estimated 5.2 million Americans and predicted to increase to 13.8 million by 2050. AD affects both cognition and emotion. Neuropsychiatric symptoms (NPS) in AD are a major cause of burden to patients, caregivers, and society and are ...

Phase

1.78 miles

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Sex Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression

The goals of this research are to investigate: (1) functional and neurochemical features associated with depression irrespective of clinical state; (2) moderating effects of hormones on stress circuitry in MDD; and (3) sex differences in symptoms. To this end, the study is enrolling adults with current depression and remitted depression, ...

Phase N/A

1.78 miles

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A Controlled Trial of Losartan in Posttraumatic Stress Disorder

There are limited current treatments available for PTSD, and the only FDA-approved medications are SSRIs, which were empirically found to be somewhat helpful. Losartan provides a potentially important and exciting development in that it is readily available, safe, inexpensive (available as a generic drug), and has a neurobiological mechanism based ...

Phase N/A

1.78 miles

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