E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 124 clinical trials
A Study of the Effects of ALKS 4230 (Nemvaleukin Alfa) on Subjects With Solid Tumors

To better understand the safety and tolerability of ALKS 4230 in humans

Alkermes Investigational Site
 (4.5 away) Contact site
  • 0 views
  • 02 May, 2021
  • +25 other locations
A Study of TAK-788 in Adults With Non-Small Cell Lung Cancer

This study is about a medicine called TAK-788, also known as mobocertinib, given to adults with non-small cell lung cancer. The main aims of this study are to check if there are any side effects from TAK-788, to learn how TAK-788 is processed by the body, and to determine the …

EGFR
growth factor
pemetrexed
HER2
cancer chemotherapy
Beth Israel Deaconess Medical Center
 (4.4 away) Contact site
  • 0 views
  • 31 May, 2021
  • +97 other locations
Safety and Efficacy of Efavaleukin Alfa in Subjects With Steroid Refractory Chronic Graft Versus Host Disease

Phase 1b: To evaluate the safety and tolerability of multiple ascending doses of efavaleukin alfa in subjects with steroid refractory chronic graft versus host disease (cGVHD). Phase 2: To evaluate the efficacy of efavaleukin alfa in subjects with steroid refractory cGVHD as measured by overall response rate (ORR) at 16 …

Dana Farber Cancer Institute
 (4.5 away) Contact site
  • 12 views
  • 12 Jun, 2021
  • +28 other locations
A Study of BLZ945 Single Agent or BLZ945 in Combination With PDR001 in Advanced Solid Tumors

The purpose of this first-in-human (FIH) study of BLZ945 given as a single agent or in combination with PDR001 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and anti-tumor activity of BLZ945, administered orally, as a single agent or in combination with PDR001, administered intravenously (i.v.) in adult patients …

Dana Farber Cancer Institute Dana Farber Cancer Institute
 (4.5 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +17 other locations
CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma

This study is being conducted to test the safety and efficacy of ramucirumab in combination with other chemotherapy in the treatment of relapsed, recurrent, or refractory synovial sarcoma (SS) in children and young adults. This trial is part of the CAMPFIRE master protocol which is a platform to accelerate the …

Dana-Farber Cancer Institute
 (4.5 away) Contact site
  • 0 views
  • 24 Jul, 2021
  • +68 other locations
Novel Use of Cyclosporine Ophthalmic Emulsion 0.05% on Application of PROSE Devices for Management of Patients With Ocular Surface Disease

The goal of this prospective observational pilot study is to evaluate the tolerability and safety of RESTASIS (cyclosporine ophthalmic solution 0.05%) when added to the PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem) lens reservoir in patients with ocular surface disease (OSD). Secondary endpoints include early (1-month) efficacy data for …

BostonSight
 (5.5 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • 1 location
Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGA3 Achromatopsia

This will be a non-randomized, open-label, Phase 1/2 study of the safety and efficacy of AGTC-402, administered to one eye by subretinal injection in individuals with achromatopsia caused by mutations in the CNGA3 gene. The primary study endpoint will be safety and the secondary study endpoint will be efficacy.

Boston Children's Hospital
 (5.2 away) Contact site
  • 152 views
  • 13 Apr, 2021
  • +11 other locations
Safety and Tolerability of hRPC in Retinitis Pigmentosa

hRPC is a cell therapy for retinitis pigmentosa. This is a first-in-human, dose escalation study in which participants with retinitis pigmentosa will receive a single subretinal injection of hRPC cells in one eye to evaluate safety and tolerability. Participants will be followed for two years to evaluate the safety and …

genetic analysis
genetic testing
diabetes
other disease
Massachusetts Eye and Ear Infirmary
 (6.0 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +4 other locations
Exablate Blood-Brain Barrier Disruption for the Treatment of rGBM in Subjects Undergoing Carboplatin Monotherapy

The purpose of this study is to evaluate the safety and feasibility of the Exablate Model 4000 Type 2 system when used as a tool to open the blood-brain-barrier (BBB) in subjects with recurrent glioblastoma (rGBM) undergoing carboplatin monotherapy.

Brigham and Women's Hospital
 (4.5 away) Contact site
  • 0 views
  • 07 Jun, 2021
  • +3 other locations
A Study of TP-0184 to Treat Anemia in Adults With IPSS-R Low or Intermediate Risk MDS

This study will evaluate preliminary safety and efficacy of TP-0184 to treat anemia when administered to adult patients with Revised International Prognostic Scoring System (IPSS-R) low or intermediate risk MDS. The recommended Phase 2 dose (RP2D) will be determined by the maximum tolerated dose (MTD) or maximum administered dose (MAD) …

Massachusetts General Hospital
 (6.0 away) Contact site
  • 0 views
  • 07 May, 2021
  • +5 other locations