E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 288 clinical trials
Study to Assess Safety and Efficacy of Engensis in Painful Diabetic Peripheral Neuropathy

The purpose of this study is to evaluate the efficacy and safety of intramuscular (IM) administration of Engensis on pain in participants with painful diabetic peripheral neuropathy (DPN) in the feet and lower legs, as compared to Placebo, as a second Phase 3, well controlled study, sufficient in supporting the …

diabetes
gabapentin
glycosylated hemoglobin
pregabalin
hemoglobin a1c
Brigham and Women's Hospital
 (4.5 away) Contact site
  • 0 views
  • 15 Jul, 2021
  • +19 other locations
Study to Investigate the Efficacy and Safety of Dupilumab in Pediatric Patients With Active Eosinophilic Esophagitis (EoE)

The Primary objective is to demonstrate the efficacy of dupilumab treatment compared with placebo in pediatric patients with active eosinophilic esophagitis (EoE) based on histologic improvement meeting validated histologic criteria. The Secondary objectives are: To demonstrate the efficacy of dupilumab compared to placebo in pediatric patients with active EoE after …

Regeneron Study Site
 (6.4 away) Contact site
  • 0 views
  • 26 May, 2021
  • +17 other locations
A Study to Evaluate the Safety and Efficacy of ION373 in Patients With Alexander Disease (AxD)

The purpose of this study is to evaluate the safety and efficacy of ION373 in improving or stabilizing gross motor function across the full range of affected domains in patients with AxD.

IONIS Investigative Site
 (6.0 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +13 other locations
Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT

This is a Phase III randomized controlled trial of a passive ROM exercise program that will be performed in infants with HLHS and other single right ventricle anomalies following the Norwood procedure at PHN and Auxiliary Centers.

Boston Children's Hospital
 (5.2 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +8 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

metastatic colorectal cancer
metastatic colorectal adenocarcinoma
platelet count
neutrophil count
hydrochlorothiazide
Steward Saint Elizabeth's Medical Center
 (2.0 away) Contact site
  • 65 views
  • 25 Jul, 2021
  • +978 other locations
Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis

This is a phase 3 study designed to evaluate whether the administration of ganciclovir increases ventilator-free days in immunocompetent patients with sepsis associated acute respiratory failure. Our hypothesis is that IV ganciclovir administered early in critical illness will effectively suppress CMV reactivation in CMV seropositive adults with sepsis-associated acute respiratory …

Brigham & Women's Hospital
 (5.4 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +19 other locations
A Study of BIIB067 When Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation

The primary objective of this study is to evaluate the efficacy of BIIB067 when initiated in presymptomatic adult carriers of a superoxide dismutase 1 (SOD1) mutation with elevated neurofilament (NF). The secondary objectives of this study are to evaluate the safety and tolerability of BIIB067 and to evaluate the effect …

Research Site
 (2.0 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +6 other locations
Safety and Efficacy Study of ICXP007 With Compression Bandaging for the Treatment of Non-Infected Venous Leg Ulcers

The main purpose of the study is to compare treatment of non-infected venous leg ulcers using ICXP007 combined with four-layer compression bandaging, placebo combined with four-layer compression bandaging and four-layer compression bandaging alone.

reflux
arterial disease
venous stasis
compression bandaging
ankle brachial pressure index
Boston Medical Center, Department of Vascular Surgery
 (6.2 away) Contact site
  • 358 views
  • 07 Nov, 2020
  • +30 other locations
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)

This Phase 3 study will evaluate the efficacy and safety of KSI-301 compared to aflibercept, in participants with neovascular (wet) age-related macular degeneration (wAMD)

Ophthalmic Consultants of Boston
 (6.0 away) Contact site
  • 0 views
  • 26 Jul, 2021
  • +65 other locations
A Prospective Controlled Treatment Trial for Post-Traumatic Headaches

Post-traumatic headaches (PTH) are the most common complaint after traumatic brain injury, possibly generated by a number of stressors to the trigeminovascular and cervical plexus networks, including inflammation of the high cervical facet joints, traumatic cranial neuralgias, migraines, and myofascial injuries. To date, no treatment guidelines exist for PTH management …

Beth Israel Deaconess Medical Center
 (4.5 away) Contact site
  • 13 views
  • 15 Jun, 2021
  • +1 other locations