E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 290 clinical trials
Study of Octaplex a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk.

To demonstrate that the efficacy of OCTAPLEX as a reversal agent in patients under Vitamin K Antagonist (VKA) therapy with the need for urgent surgery with significant bleeding risk is clinically non-inferior to that Beriplex P/N (Kcentra).

Octapharma Research Site
 (6.0 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +76 other locations
Establishing the Safety and Efficacy of Reloxaliase in Patients With Enteric Hyperoxaluria

The purpose of this study is to determine the efficacy, durability and long-term safety of reloxaliase in patients with enteric hyperoxaluria.

Brigham and Women's Hospital
 (4.5 away) Contact site
  • 7 views
  • 04 Aug, 2021
  • +83 other locations
Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)

This study will evaluate the efficacy and safety of pembrolizumab (MK-3475) with lenvatinib (E7080/MK-7902) vs. docetaxel in participants with metastatic non-small cell lung cancer (NSCLC) and progressive disease (PD) after platinum doublet chemotherapy and treatment with one prior anti-PD-1/PD-L1 monoclonal antibody (mAb). The primary hypotheses of this study are that …

pd-l1
measurable disease
ct scan
monoclonal antibodies
metastasis
The Mass General Cancer Center at Newton-Wellesley ( Site 1692)
 (4.7 away) Contact site
  • 122 views
  • 04 Aug, 2021
  • +149 other locations
Bezlotoxumab (MK-6072) Versus Placebo in Children With Clostridium Difficile Infection (CDI) (MK-6072-001)

The primary objectives of this study are to evaluate the pharmacokinetics (PK), safety, and tolerability of bezlotoxumab in children aged 1 to <18 years of age with a confirmed diagnosis of Clostridium difficile infection (CDI) who are receiving antibacterial drug treatment. The primary hypothesis is that the area under the …

a 10
clostridium difficile
bezlotoxumab
Tufts Medical Center-Floating Hospital for Children ( Site 0046)
 (6.4 away) Contact site
  • 71 views
  • 31 Jul, 2021
  • +79 other locations
A Study of Galcanezumab (LY2951742) in Participants 6 to 17 Years of Age With Episodic Migraine

The main purpose of this study is to evaulate the efficacy and safety of galcanezumab in participants 6 to 17 years of age for the preventive treatment of episodic migraine. The primary objective is to demonstrate the superiority of galcanezumab versus placebo in the reduction of monthly migraine headache days …

MedVadis Research Corp
 (4.3 away) Contact site
  • 43 views
  • 26 Jul, 2021
  • +93 other locations
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFPEF) is common and deadly but without therapy. Inconclusive studies such as TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is …

n-terminal pro-bnp
atrial fibrillation
aldosterone antagonists
spironolactone
aldosterone
Newton-Wellesley Hospital
 (4.7 away) Contact site
  • 46 views
  • 02 Jul, 2021
  • +147 other locations
Multi-arm Optimization of Stroke Thrombolysis

The primary efficacy objective of the MOST trial is to determine if argatroban (100g/kg bolus followed by 3g/kg per minute for 12 hours) or eptifibatide (135g/kg bolus followed by 0.75g/kg/min infusion for two hours) results in improved 90-day modified Rankin scores (mRS) as compared with placebo in acute ischemic stroke …

Boston Medical Center
 (6.2 away) Contact site
  • 121 views
  • 04 Aug, 2021
  • +87 other locations
A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

The purpose of this study is to evaluate the efficacy and safety of nipocalimab compared to placebo in participants with generalized myasthenia gravis (gMG).

generalized myasthenia gravis
weakness
St. Elizabeth Medical Center
 (2.0 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +116 other locations
Long Term Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

This is an extension study of the Phase 3 Studies 15-AVP-786-301, 15-AVP-786-302, and 17-AVP-786-305, which also allows participants from the Phase 2 Study 12-AVR-131 to be included.

Boston Center for Memory
 (4.7 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +296 other locations
Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer

Phase III, double-blind, randomised study assessing the efficacy of capivasertib + fulvestrant vs placebo + fulvestrant for the treatment of patients with locally advanced (inoperable) or metastatic HR+/HER2- breast cancer following recurrence or progression on or after AI therapy.

Research Site
 (6.4 away) Contact site
  • 50 views
  • 04 Aug, 2021
  • +223 other locations