E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 306 clinical trials
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A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172 weeks and may include up to 44 visits.

ulcerative colitis or crohn's
crohn's disease
ulcerative colitis
colitis
mirikizumab
MGH for Children - Waltham
 (4.3 away) Contact site
  • 0 views
  • 12 Sep, 2021
  • +6 other locations
None
A Study to Assess the Safety and Efficacy of Inclacumab in Participants With Sickle Cell Disease Experiencing Vaso-occlusive Crises

This Phase 3 study will assess the safety and efficacy of inclacumab, a P-selectin inhibitor, in reducing the frequency of vaso-occlusive crises (VOCs) in approximately 240 adult and adolescent participants ( 12 years of age) with sickle cell disease (SCD). Participants will be randomized to receive inclacumab or placebo.

hydroxyurea
glutamine
thalassemia
voxelotor
narcotics
Brigham and Women's Hospital
 (4.5 away) Contact site
  • 0 views
  • 19 Aug, 2021
  • +2 other locations
None
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics

There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals. There is great controversy over whether or not these animal data are relevant to human clinical scenarios. The changes seen in preclinical studies …

major surgery
opioid
neurodevelopmental disorders
sevoflurane
ketamine
Boston Children's Hospital
 (5.2 away) Contact site
  • 360 views
  • 17 Sep, 2021
  • +26 other locations
None
Adjuvant Avelumab in Merkel Cell Cancer

This randomized phase III trial studies how well avelumab works in treating patients with Merkel cell cancer that has spread to the lymph nodes and have undergone surgery and/or radiation therapy. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere …

Dana Farber Cancer Institute
 (4.5 away) Contact site
  • 4 views
  • 03 Jun, 2021
  • +11 other locations
None
Comparison of the Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis

The main purpose of this study is to compare the Human Acellular Vessel (HAV) with arteriovenous fistula (AVF) when used for hemodialysis access

platelet count
renal failure
chronic renal failure
dialysis
nephropathy
Brigham and Women's Hospital
 (5.2 away) Contact site
  • 122 views
  • 11 Jul, 2021
  • +35 other locations
None
Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase

The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S. aureus) bloodstream infections (BSI), including right-sided infective endocarditis (IE). Patients will be randomized to …

CF-301-105 Study Site
 (8.1 away) Contact site
  • 3 views
  • 15 Oct, 2021
  • +46 other locations