E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 323 clinical trials
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Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases

Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while excluding the surrounding normal brain. Whole brain radiation therapy with hippocampal …

stereotactic radiosurgery
brain tumor
cancer
metastasis
whole-brain radiotherapy
Tufts Medical Center
 (6.4 away) Contact site
  • 98 views
  • 15 Nov, 2021
  • +72 other locations
None
A Trial to Evaluate the Safety Efficacy and Tolerability of Brexpiprazole in Treating Agitation Associated With Dementia of the Alzheimer's Type

This study compares the efficacy of 2 doses of brexpiprazole with placebo in subjects with agitation associated with dementia of the Alzheimer's type.

dementia
alzheimer's disease
mini-mental state examination
agitation
Alzheimer Disease Center
 (6.1 away) Contact site
  • 58 views
  • 01 May, 2021
  • +65 other locations
None
Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency as Open Label Extension

This is an open-label extension study for patients previously enrolled in the AB2 Bio Ltd. ongoing Phase III clinical trial NLRC4/XIAP.2016.001 (IND N 127953). This OLE study will evaluate the long-term safety and tolerability of Tadekinig alfa in patients suffering from pediatric monogenic autoinflammatory diseases harboring deleterious mutations of NLRC4 …

Boston Children's Hospital
 (5.2 away) Contact site
  • 6 views
  • 26 Apr, 2021
  • +11 other locations
None
A 12-week Extension Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type

Active treatment extension study of the 331-14-213 trial, to assess the long-term safety and tolerability of oral brexpiprazole as treatment in adult subjects with agitation associated with dementia of the Alzheimer's type (AAD).

dementia
agitation
Alzheimer Disease Center
 (6.1 away) Contact site
  • 21 views
  • 28 Apr, 2021
  • +26 other locations
None
Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS)

This is a prospective, multicenter, open-label Phase 3 study of a microbiota suspension of intestinal microbes. Patients who have had at least one recurrence of CDI after a primary episode and have completed at least one round of standard-of-care oral antibiotic therapy or have had at least two episodes of …

stool test
antibiotic therapy
microbiota
antibiotics
diarrhea
Boston
 (6.0 away) Contact site
  • 35 views
  • 22 Apr, 2021
  • +59 other locations
None
Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

This randomized phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that have spread to other places in the body (advanced). Cabozantinib is a chemotherapy drug known as a tyrosine kinase inhibitor, and it targets specific tyrosine …

gastroenteropancreatic neuroendocrine tumor
gilbert's syndrome
cancer
platelet count
history of allergic reaction
Lahey Hospital and Medical Center
 (8.1 away) Contact site
  • 190 views
  • 01 Dec, 2021
  • +290 other locations
None
Exercise Training to Improve Cognitive Function

This project is assessing the feasibility of a novel home-based exercise intervention to improve episodic memory in individuals with mild cognitive impairment.

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
 (5.4 away) Contact site
  • 1 views
  • 21 Oct, 2021
  • 1 location
None
Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol

To determine if Alvimopan during open or robotic radical cystectomy with urinary diversion results in quicker return of bowel function (GI-2 recovery = time to upper [first toleration of solid food] and lower [first bowel movement] gastrointestinal recovery) compared to placebo.

ileal conduit
urinary diversion
radical cystectomy
Brigham and Women's Hospital
 (5.2 away) Contact site
  • 0 views
  • 26 Jul, 2021
  • 1 location
None
A Study to Evaluate the Efficacy Safety and Drug Concentration of Certolizumab Pegol (CZP) in Children and Adolescent Study Participants With Moderate to Severe Chronic Plaque Psoriasis (PSO)

The purpose of the study is to demonstrate the efficacy and safety of certolizumab pegol in the treatment of moderate to severe chronic plaque psoriasis in study participants aged 6 to 11 and 12 to 17 years.

Ps0007 50158
 (2.0 away) Contact site
  • 9 views
  • 12 Sep, 2021
  • +49 other locations
None
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)

The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters …

blood transfusion
sickle hemoglobin
anti-thymocyte globulin
exchange transfusion
thalassemia
Boston Medical Center
 (6.2 away) Contact site
  • 24 views
  • 24 Sep, 2021
  • +15 other locations