E Watertown, Massachusetts Clinical Trials

A listing of E Watertown, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 302 clinical trials
Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM

The purpose of this research study is to evaluate the efficacy and safety of an empagliflozin dosing regimen and one dose of linagliptin in patients with type 2 diabetes who are aged 10 to below 18 years and are currently taking metformin, insulin or both drugs (DINAMO TM) or who …

metformin
c-peptide
fasting
empagliflozin
linagliptin
Joslin Diabetes Center
 (4.5 away) Contact site
  • 106 views
  • 20 Sep, 2021
  • +248 other locations
Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Subjects

Randomized, open-label, multi-center, comparative trial to assess the efficacy and safety in immunocompromised subjects with acyclovir resistant or acyclovir susceptible mucocutaneous HSV infection, treated with pritelivir 100 mg once daily (following a loading dose of 400 mg as first dose to rapidly reach steady-state plasma concentration) or foscarnet 40 mg/kg …

copper
organ transplantation
granulocytopenia
neutropenia
famciclovir
Brigham and Women's Hospital
 (5.2 away) Contact site
  • 14720 views
  • 19 Sep, 2021
  • +19 other locations
Therapeutic Use of Tadekinig Alfa in NLRC4 Mutation and XIAP Deficiency

This is a Phase 3 study to assess the safety and efficacy of Tadekinig alfa in patients with monogenic, interleukin-18 (IL 18) driven autoinflammation due to Nucleotide-binding oligomerization domain, leucine-rich repeat and caspase recruiting domain (CARD domain) containing 4 (NLRC4) - Macrophage activation syndrome (MAS) mutation (NLRC4-MAS mutation) or X-linked …

Boston Children's Hospital
 (5.2 away) Contact site
  • 94 views
  • 15 Jun, 2021
  • +15 other locations
A Study to Compare the Long-term Outcomes After Two Different Anaesthetics

There is considerable evidence that most general anaesthetics modulate brain development in animal studies. The impact is greater with longer durations of exposure and in younger animals. There is great controversy over whether or not these animal data are relevant to human clinical scenarios. The changes seen in preclinical studies …

neurodevelopmental disorders
remifentanil
major surgery
dexmedetomidine
propofol
Boston Children's Hospital
 (5.2 away) Contact site
  • 360 views
  • 17 Sep, 2021
  • +26 other locations
Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

This randomized phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that have spread to other places in the body (advanced). Cabozantinib is a chemotherapy drug known as a tyrosine kinase inhibitor, and it targets specific tyrosine …

neutrophil count
history of allergic reaction
potassium
international normalized ratio
calcium
Lahey Hospital and Medical Center
 (8.1 away) Contact site
  • 190 views
  • 19 Sep, 2021
  • +289 other locations
Continuous Erector Spinae Block Versus Continuous Paravertebral Block

Overall Aim: To evaluate the efficacy of continuous erector spinae block (ESB) versus continuous paravertebral block (PVB) for postoperative analgesia in children and adolescents undergoing surgical procedures via unilateral thoracotomy. Hypothesis: The investigators hypothesize that ESP block efficacy is not inferior to that of PVB with respect to pain control …

thoracotomy
postoperative pain relief
opiates
analgesia
ropivacaine
Boston Children"S Hospital
 (6.2 away) Contact site
  • 0 views
  • 27 Feb, 2021
  • 1 location
Testing The Addition of a New Anti-cancer Drug Venetoclax to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated Older Patients With Chronic Lymphocytic Leukemia

This phase III trial compares adding a new anti-cancer drug (venetoclax) to the usual treatment (ibrutinib plus obinutuzumab) in older patients with chronic lymphocytic leukemia who have not received previous treatment. The addition of venetoclax to the usual treatment might prevent chronic lymphocytic leukemia from returning. This trial also will …

corticosteroids
rituximab
ibrutinib
neutrophil count
chronic lymphocytic leukemia
Tufts Medical Center
 (6.4 away) Contact site
  • 382 views
  • 19 Sep, 2021
  • +740 other locations
The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE

The purpose of this study is to compare the efficacy, safety, and durability of two different strategies to treat participants with a history of sub-optimal adherence and control of their HIV infection: long-acting (LA) antiretroviral therapy (ART) and all-oral standard of care (SOC).

HIV Vaccine
antiretroviral therapy
hiv-1 infection
hiv test
antibody test
Brigham and Women's Hospital Therapeutics Clinical Research Site (BWH TCRS) CRS
 (5.2 away) Contact site
  • 242 views
  • 06 Aug, 2021
  • +33 other locations
Lenalidomide and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them …

immunoglobulins
platelet count
blood test
plasmacytoma
arrhythmia
Tufts Medical Center
 (6.4 away) Contact site
  • 15 views
  • 19 Sep, 2021
  • +488 other locations
Exercise Training to Improve Cognitive Function

This project is assessing the feasibility of a novel home-based exercise intervention to improve episodic memory in individuals with mild cognitive impairment.

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
 (5.4 away) Contact site
  • 1 views
  • 12 Feb, 2021
  • 1 location