Brookline, Massachusetts Clinical Trials

A listing of Brookline, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 2067 clinical trials
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes …

percutaneous coronary intervention
arterial disease
Beth Israel Deaconess Medical Center
 (2.3 away) Contact site
  • 14 Mar, 2021
  • +47 other locations
Lysosomal Acid Lipase (LAL) Deficiency Registry

This is an observational, multi-center, international disease registry designed to collect longitudinal data and create a knowledge base that will be utilized to improve the care and treatment of patients with LAL Deficiency. Participation in the Registry by both physicians and patients is voluntary.

 (2.5 away) Contact site
  • 01 Feb, 2021
  • +27 other locations
Natural History Study of Synucleinopathies

Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein -synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of movement, coordination difficulties or mild cognitive impairment. Development …

lewy body disease
parkinson's disease
Beth Israel Deaconess Medical Center
 (4.5 away) Contact site
  • 05 Feb, 2021
  • +9 other locations
Parkinson's Foundation Quality Improvement Initiative

In a recent study it was found that neurologist care for Parkinson's provides a 20% reduction in nursing home placement, hip fracture, and death (Willis 2011). However, as the authors recognized, the investigators don't know what it is about expert care that delivers this benefit. The Parkinson's Foundation's Quality Improvement …

Beth Israel Deaconess Medical Center Parkinson's Disease Movement Disorder Center
 (4.5 away) Contact site
  • 23 Jan, 2021
  • +23 other locations
DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer

The goal of this project is to improve lung cancer screening in high-risk individuals by identifying biomarkers of preclinical disease and disease risk that are measured in minimally invasive and non-invasive biospecimens. Existing biomarkers for lung cancer diagnosis as well as new biomarkers discovered specifically in this clinical setting will …

fiberoptic bronchoscopy
lung cancer screening
Boston University Medical Center
 (3.3 away) Contact site
  • 01 May, 2021
  • +14 other locations
Identification of Biomarkers for Patients With Vascular Anomalies

The study will use blood (serum and plasma) and tissue obtained from participants undergoing prescribed surgical resection of vascular anomalies of interest proposed in this study. The study will also use blood (serum and plasma) and tissue collected and stored in a tissue bank maintained by the Department of Hematology/Oncology.

Boston Children's Hospital
 (2.5 away) Contact site
  • 15 Feb, 2021
  • +1 other locations
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 20,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD …

Beth Israel Deaconess Medical Center
 (2.3 away) Contact site
  • 20 May, 2021
  • +255 other locations
A Prospective Study of Plasma Genotyping as a Noninvasive Biomarker for Genotype-directed Cancer Care

Tumor genotyping has become an essential biomarker for the care of advanced lung cancer and melanoma, and is currently used to identify patients for treatment with targeted kinase inhibitors like erlotinib and vemurafenib. However, tumor genotyping can be slow and cumbersome, and is limited by availability of tumor biopsy tissue …

egfr t790m
Dana-Farber Cancer Institute
 (2.3 away) Contact site
  • 26 Sep, 2021
  • 1 location
Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Peripheral Neuropathy Receiving Paclitaxel for Breast Cancer

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with peripheral neuropathy receiving chemotherapy for breast cancer. Studying samples of germline DNA in the laboratory from patients with peripheral neuropathy receiving paclitaxel for breast cancer may help doctors learn more …

peripheral neuropathy
breast cancer
biomarker analysis
Eastern Cooperative Oncology Group
 (2.3 away) Contact site
  • 30 Mar, 2021
  • 1 location
Cerebral Palsy Hip Outcomes Project - International Multi-centre Study

The primary purpose of the project is to evaluate the effectiveness of different intervention strategies to prevent or relieve symptoms associated with hip instability in children with severe cerebral palsy, using the validated Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) questionnaire as the primary outcome measure …

Children's Hospital Boston
 (4.5 away) Contact site
  • 18 Feb, 2021
  • +26 other locations