Brookline, Massachusetts Clinical Trials

A listing of Brookline, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 2067 clinical trials
Modifiers of Disease Severity in Cerebral Cavernous Malformations

Cerebral cavernous malformations (CCMs) are clusters of abnormal blood vessels in the brain and spine. CCMs can bleed and cause strokes, seizures, and headaches. CCMs are often caused by an inherited gene mutation (alteration) in one of three CCM genes (CCM1, CCM2, or CCM3). There is a wide range of …

Boston Children's Hospital
 (2.5 away) Contact site
  • 26 Jan, 2021
  • +6 other locations
MOON Shoulder Instability-Cohort of Patients Undergoing Operative Treatment.

This project will be a multi-center, prospective longitudinal cohort for all patients undergoing primary shoulder instability surgery, excluding isolated SLAP repairs. We will be looking for risk factors for recurrent instability, revision surgery, and poor outcomes. Patients will be asked to complete the RAND-36, ASES, Shoulder Activity, EQ-5D and WOSI …

Brigham and Women's Hospital
 (4.5 away) Contact site
  • 23 Jan, 2021
  • +10 other locations
Boston Birth Cohort Study

Early life exposures may lead to adverse effects on health in later life. The Boston birth Cohort study is designed to study a broad array of early life factors and their effects on pregnancy, infancy, and child health outcomes.

Boston Medical Center
 (3.3 away) Contact site
  • 24 Jan, 2021
  • 1 location
Prospective Screening for Breast Cancer-related Lymphedema

The primary objectives of this study are twofold: 1) to detect and determine the level of symptoms, functional disability, and changes in quality of life that breast cancer patients experience from changes in their arms during and after treatment for breast cancer by collecting patient reported outcome measures, objective measurements, …

bioimpedance spectroscopy
cancer treatment
breast cancer
Massachusetts General Hospital
 (2.3 away) Contact site
  • 22 Aug, 2021
  • 1 location
Longitudinal Study of the Porphyrias

The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortality in people with these disorders.

Massachusetts General Hospital
 (4.5 away) Contact site
  • 26 Jan, 2021
  • +14 other locations
Genetics of Severe Early Onset Epilepsies

Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to disorders related to epilepsy. These findings may help explain the broad spectrum of clinical characteristics and outcomes seen in people with epilepsy.

Boston Children's Hospital
 (2.5 away) Contact site
  • 05 Aug, 2021
  • 1 location
Genetic Studies of Strabismus Congenital Cranial Dysinnervation Disorders (CCDDs) and Their Associated Anomalies

The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.

Boston Children's Hospital
 (2.5 away) Contact site
  • 19 Sep, 2021
  • 1 location
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention

Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes …

percutaneous coronary intervention
arterial disease
Beth Israel Deaconess Medical Center
 (2.3 away) Contact site
  • 14 Mar, 2021
  • +47 other locations
Lysosomal Acid Lipase (LAL) Deficiency Registry

This is an observational, multi-center, international disease registry designed to collect longitudinal data and create a knowledge base that will be utilized to improve the care and treatment of patients with LAL Deficiency. Participation in the Registry by both physicians and patients is voluntary.

 (2.5 away) Contact site
  • 01 Feb, 2021
  • +27 other locations
Natural History Study of Synucleinopathies

Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein -synuclein in the nervous system. Onset is usually in late adulthood at age 50 or older. Usually, synucleinopathies present clinically with slowness of movement, coordination difficulties or mild cognitive impairment. Development …

multiple system atrophy
mild cognitive impairment
lewy body disease
parkinson's disease
Beth Israel Deaconess Medical Center
 (4.5 away) Contact site
  • 05 Feb, 2021
  • +9 other locations