Attleboro, Massachusetts Clinical Trials

A listing of Attleboro, Massachusetts clinical trials actively recruiting patient volunteers.

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Found 15 clinical trials
BrUOG 379 Phase Ib/II Trial ONC201 + Nivolumab in MSS mCRC

This is a single arm Phase Ib/II, open label, safety, pharmacokinetic, pharmacodynamics and efficacy study of ONC201 in combination with Opdivo (Nivolumab) in adult patients with metastatic colorectal cancer, for whom no standard therapy is available. This study will enroll adult patients with metastatic colorectal cancer who progressed after at …

growth factor
folfiri regimen
serum bilirubin level
metastasis
cetuximab
Lifespan Cancer Institute: The Miriam and Rhode Island Hospitals
 (9.6 away) Contact site
  • 0 views
  • 14 May, 2021
  • 1 location
A Study of Copanlisib Combined With Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer

This is a single arm Phase Ib/II, open label, safety, pharmacokinetic and efficacy clinical study in adult patients with metastatic castration-resistant prostate cancer (mCRPC). Patients will be treated with the combination of copanlisib and rucaparib for as long as the patient does not have clinically significant progressive disease and/or unacceptable …

progressive disease
orchiectomy
metastasis
rad51c
neutrophil count
Lifespan Cancer Institute
 (9.6 away) Contact site
  • 0 views
  • 26 Jan, 2021
  • 1 location
MEDI9447(Oleclumab) Pancreatic Chemotherapy Combination Study.

The objective of this study is to evaluate the safety, tolerability, and antitumor activity of oleclumab (MEDI9447) in combination with or without durvalumab plus chemotherapy in subjects with metastatic pancreatic cancer.

leucovorin
chemotherapy regimen
paclitaxel
metastasis
gemcitabine
Research Site
 (9.6 away) Contact site
  • 63 views
  • 24 May, 2021
  • +26 other locations
GEN3013 Trial in Patients With Relapsed Progressive or Refractory B-Cell Lymphoma

The trial is an open-label, multi-center safety trial of epcoritamab GEN3013 (DuoBody-CD3xCD20). The trial consists of two parts: a dose escalation part phase 1, first-in-human (FIH) and an expansion part phase 2a.

renal function
mantle cell lymphoma
pet/ct scan
renal function tests
lymphoma
Rhode Island Hospital
 (9.6 away) Contact site
  • 316 views
  • 24 Feb, 2021
  • +98 other locations
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemia"

This is a Phase 1-2, multicenter, international, single-arm, open-label study designed to identify a recommended dose of bosutinib administered orally once daily in pediatric patients with newly diagnosed chronic phase Ph+ CML (ND CML) and pediatric patients with Ph+CML who have received at least one prior TKI therapy (R/I CML), …

chronic myeloid leukemia
myeloid leukemia
ejection fraction
philadelphia chromosome
bosutinib
Rhode Island Hospital
 (9.6 away) Contact site
  • 0 views
  • 13 Jun, 2021
  • +29 other locations
Dose Escalation of DF6002 in Patients With Advanced Solid Tumors and Expansion in Selected Indications

This study is a Phase 1/2, open-label, dose-escalation study with a consecutive parallel-group efficacy expansion study, designed to determine the safety, tolerability, PK, pharmacodynamics, and preliminary anti-tumor activity of DF6002 as monotherapy and in combination with nivolumab.

renal function
hepatitis
solid tumour
progressive disease
lung carcinoma
Rhode Island Hospital
 (9.6 away) Contact site
  • 12 views
  • 13 Jun, 2021
  • +6 other locations
Comparing Two Treatments That Both Target Smoking Cessation and Weight Loss at the Same Time.

The study has two phases. In Phase 1, the investigators will revise and pilot the distress tolerance (DT) protocol that was originally developed and piloted in a previous study (2P20 GM103430, Spas, PI). Despite the 4-week post-intervention treatment outcomes demonstrating the DT protocol's association with smoking cessation and weight loss, …

Rhode Island College
 (9.4 away) Contact site
  • 0 views
  • 23 Jan, 2021
  • 1 location
Mifepristone for the Prevention of Relapses of Alcohol Drinking

The goal of this study is to determine if, under stress, alcohol drinking is reduced using mifepristone

Center for Alcohol and Addiction Studies, Brown University
 (8.8 away) Contact site
  • 4 views
  • 03 Feb, 2021
  • 1 location
Study of GEN-1 With NACT for Treatment of Ovarian Cancer (OVATION 2)

This is a randomized, open label, multicenter trial to evaluate the safety, dosing, efficacy and biological activity of intraperitoneal GEN-1 plus NACT compared to NACT alone.

paclitaxel
carboplatin
hormone therapy
endometrioid adenocarcinoma
renal function tests
Women & Infants Hopsital of Rhode Island
 (9.3 away) Contact site
  • 151 views
  • 02 Jun, 2021
  • +39 other locations
Impact of Nicotine Reduction on Adolescent Cigarette Use Alternative Tobacco Use and Harm From Tobacco

Adolescents are an important vulnerable population to consider as the FDA moves toward a nicotine reduction policy. Such a policy, which would mandate a reduction of nicotine in all commercially available cigarettes, has the potential to transform public health and greatly reduce the toll of tobacco-related death and disease. Yet, …

Brown University School of Public Health
 (8.8 away) Contact site
  • 6 views
  • 23 Jan, 2021
  • 1 location