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Indianapolis, Indiana Clinical Trials

A listing of Indianapolis, Indiana clinical trials actively recruiting patient volunteers.

RESULTS

Found (802) clinical trials

Fontan Udenafil Exercise Longitudinal Assessment Trial

This study is a randomized, double-blinded, efficacy trial of the effects of udenafil vs. placebo on the background of standard therapy on maximal VO2 (ml/kg/min) from baseline to six months in adolescent survivors of the Fontan procedure. . The target sample size is 400 subjects (200 per group).

Phase

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A Extension Study of Udenafil in Adolescents

This will be an open-label extension study. All enrolled subjects will be provided with udenafil for the duration of the study. Subjects completing the Phase III FUEL study will be eligible for recruitment. Additional subjects will be recruited as needed to ensure a minimum of 300 total subjects enroll. Safety, ...

Phase

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Short Stay Unit vs Hospitalization in Acute Heart Failure

Nearly 85% of acute heart failure (AHF) patients who present to the emergency department (ED) with acute heart failure (AHF) are hospitalized. Once hospitalized, within 30 days post-discharge, 27% of patients are re-hospitalized or die. Attempts to improve outcomes with novel therapies have all failed. The evidence for existing AHF ...

Phase

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Improving Adolescent Health Outcomes Through Preventive Care Transformation

Preventive care for adolescents is vitally important for maximizing their health and well-being. Unfortunately, pediatric primary care frequently fails to meet the preventive needs of adolescents as demonstrated by poor health outcomes for this population. In this grant application, the investigators propose to expand an existing computer decision support system ...

Phase N/A

2.26 miles

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Safety Study of Unlicensed Investigational Cord Blood Units Manufactured by the NCBP for Unrelated Transplantation

The primary aim of this study is to examine the safety of administration of the unlicensed investigational NCBP HPC-CORD BLOOD products in a multi-institution setting. Therefore, the study will evaluate prospectively the incidence of serious adverse reactions as well as the incidence of all infusion related reactions after administration of ...

Phase

2.36 miles

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Multi-Center Prospective Randomized Comparison of AWBAT -D vs. Xeroform or Glucan II for Treatment of Donor Sites in Burn Surgery

The purpose of this study is to evaluate AWBAT™-D compared to Xeroform™ or Glucan II™ for the treatment of donor sites in burn surgery. Primary Study Goals: - To compare the rate of healing of donor sites. - To compare patient reported perception of pain - To compare the potential ...

Phase N/A

2.36 miles

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Anti-VEGF vs. Prompt Vitrectomy for VH From PDR

Although vitreous hemorrhage (VH) from proliferative diabetic retinopathy (PDR) can cause acute and dramatic vision loss for patients with diabetes, there is no current, evidence-based clinical guidance as to what treatment method is most likely to provide the best visual outcomes once intervention is desired. Intravitreous anti-vascular endothelial growth factor ...

Phase

2.4 miles

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Zimmer MotionLoc in Distal Tibia Fractures

Primary Endpoint: Radiographic & clinical fracture healing at 3 months post-surgery. Secondary Endpoints: Complications Radiologic & clinical fracture healing at 6 weeks, 3, 6, and 12 months post-surgery. Callus size & distribution at 6 weeks, 3, 6, and 12 months post-surgery. Radiologic fracture healing is defined as bridging of three ...

Phase N/A

2.63 miles

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A Phase 3 Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis

Complement 5a and its receptor C5aR (CD88) are involved in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This is a randomized, double-blind, active-controlled Phase 3 study to evaluate the safety and efficacy of the orally-administered, selective C5aR inhibitor CCX168 (avacopan) in inducing and sustaining remission in patients with anti-neutrophil ...

Phase

2.63 miles

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Study of ADXS11-001 in Subjects With High Risk Locally Advanced Cervical Cancer

This is a double-blind, placebo-controlled randomized study of ADXS11 001 administered in the adjuvant setting after completion of cisplatin-based CCRT in subjects with locally advanced cervical cancer at higher risk for recurrence (HRLACC), or death. All eligible subjects will have received CCRT administered with curative intent according to institutional/national guidelines ...

Phase

2.63 miles

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