Springfield, Illinois Clinical Trials

A listing of Springfield, Illinois clinical trials actively recruiting patient volunteers.

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Found 57 clinical trials
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The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

The objective of the RADIANCE II Pivotal study is to demonstrate the effectiveness and safety of the Paradise System in subjects with Stage 2 hypertension on 0-2 medications at the time of consent. Prior to randomization, subjects will be hypertensive in the absence of hypertension medication.

angiography
hypertensive medication
renal angiogram
antihypertensive drugs
antihypertensive therapy
Southern Illinois University
 (3.2 away) Contact site
  • 877 views
  • 01 Aug, 2021
  • +82 other locations
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity will be assessed. ABBV-154 is …

stiffness
methotrexate
antirheumatics
rheumatism
Springfield Clinic /ID# 228124
 (3.6 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +291 other locations
OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)

A 2-year phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.

COAST Investigational Site
 (1.2 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +50 other locations
Efficacy and Safety APT-1011 in Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2)

This is a 2-part randomized, double-blind, placebo-controlled study of APT-1011 in adults and adolescents (12 years) with EoE. Part A will evaluate the efficacy and safety of APT-1011 3 mg administered HS for the induction of response to treatment (histologic and symptomatic) over 12 weeks. Part B will evaluate histological …

esophagogastroduodenoscopy
dysphagia
Adare Pharmaceuticals
 (1.2 away) Contact site
  • 93 views
  • 19 Jul, 2021
  • +141 other locations
A Prospective Multi-center Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

depressive episode
depressive symptoms
depressive disorder
Southern Illinois University School of Medicine
 (3.5 away) Contact site
  • 637 views
  • 01 Aug, 2021
  • +65 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

monoclonal antibodies
rifampin
hydrochlorothiazide
metastatic colorectal cancer
platelet count
Memorial Medical Center
 (3.2 away) Contact site
  • 65 views
  • 27 Jul, 2021
  • +978 other locations
A Study to Evaluate Safety and Effectiveness of Cendakimab (CC-93538) in Participants With Moderate to Severe Atopic Dermatitis

The purpose of this study is to evaluate the effectiveness and safety of 3 dose regimen of CC-93538 in adult participants with moderate to severe Atopic Dermatitis (AD).

ultraviolet light
corticosteroids
topical agents
asthma
montelukast
Sneeze Wheeze and Itch Associates LLC
 (3.6 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +84 other locations
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer the CompassHER2 RD Trial

This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted …

Memorial Medical Center
 (3.2 away) Contact site
  • 0 views
  • 26 Jul, 2021
  • +762 other locations
A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin

The purpose of this study is to compare the safety and efficacy of the study drug tirzepatide to insulin lispro (U100) three times a day in participants with type 2 diabetes that are already on insulin glargine (U100), with or without metformin.

insulin
type 2 diabetes mellitus
metformin
hemoglobin a1c
Prairie Education and Research Cooperative
 (1.3 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +164 other locations
Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy

This phase III trial compares survival in urothelial cancer patients who stop immune checkpoint inhibitor treatment after being treated for about a year to those patients who continue treatment with immune checkpoint inhibitors. Immunotherapy with monoclonal antibodies, such as avelumab, durvalumab, pembrolizumab, atezolizumab, and nivolumab, may help the body's immune …

Memorial Medical Center
 (3.2 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +282 other locations