Plainfield, Illinois Clinical Trials

A listing of Plainfield, Illinois clinical trials actively recruiting patient volunteers.

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Found 21 clinical trials
A Prospective Multi-center Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

depressive disorder
depressive symptoms
depressive episode
Joliet Center For Clinical Research
 (5.2 away) Contact site
  • 637 views
  • 01 Aug, 2021
  • +65 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

cancer treatment
metastatic colorectal adenocarcinoma
major surgery
solid tumors
hydrochlorothiazide
Edward Hospital/Cancer Center?Plainfield
 (3.9 away) Contact site
  • 65 views
  • 27 Jul, 2021
  • +978 other locations
A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant

The purpose of this study is to assess the efficacy of seltorexant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with an selective serotonin reuptake …

Joliet Center for Clinical Research
 (5.2 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +115 other locations
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)

Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence. More effective treatment options are needed for this patient population. This study will examine the efficacy and safety of trastuzumab deruxtecan (T-DXd) compared with trastuzumab emtansine …

Edward Cancer Center Plainfield
 (4.0 away) Contact site
  • 0 views
  • 17 Jul, 2021
  • +425 other locations
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

metastasis
tumor cells
squamous cell carcinoma
pembrolizumab
lung cancer
Edward Hospital/Cancer Center?Plainfield
 (3.9 away) Contact site
  • 1103 views
  • 01 Aug, 2021
  • +1138 other locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

brain metastasis
erdafitinib
antiretroviral therapy
treatment regimen
white blood cells
Edward Hospital/Cancer Center?Plainfield
 (3.9 away) Contact site
  • 6087 views
  • 01 Aug, 2021
  • +1020 other locations
Study of Telisotuzumab Vedotin (ABBV-399) in Participants With Previously Treated c-Met+ Non-Small Cell Lung Cancer

This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that over express c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage …

growth factor
epidermal growth factor
stage iv non-small cell lung cancer
cancer treatment
lung carcinoma
Joliet Oncology-Hematology /ID# 203238
 (5.2 away) Contact site
  • 118 views
  • 01 Aug, 2021
  • +366 other locations
Chemoradiation With or Without Atezolizumab in Treating Patients With Limited Stage Small Cell Lung Cancer

This phase III trial studies how well chemotherapy and radiation therapy (chemoradiation) with or without atezolizumab works in treating patients with limited stage small cell lung cancer. Drugs used in chemotherapy, such as etoposide, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by …

Edward Hospital/Cancer Center?Plainfield
 (3.9 away) Contact site
  • 85 views
  • 01 Aug, 2021
  • +334 other locations
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer The PDIGREE Study

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

interleukin 2
measurable disease
cabozantinib
metastasis
tumor cells
Edward Hospital/Cancer Center?Plainfield
 (3.9 away) Contact site
  • 157 views
  • 01 Aug, 2021
  • +677 other locations
Study of First-line Pembrolizumab (MK-3475) With Lenvatinib (MK-7902/E7080) in Urothelial Carcinoma Cisplatin-ineligible Participants Whose Tumors Express Programmed Cell Death-Ligand 1 and in Participants Ineligible for Platinum-containing Chemotherapy (MK-7902-011/E7080-G000-317/ LEAP-011)

The purpose of this study is to evaluate the efficacy and safety of lenvatinib (MK-7902/E7080) in combination with pembrolizumab (MK-3475) in the treatment of cisplatin-ineligible participants with a Programmed Cell Death-Ligand 1 (PD-L1) Combined Positive Score (CPS) 10, or in participants ineligible for any platinum-containing chemotherapy regardless of CPS, with …

platinum-based chemotherapy
cancer
solid tumour
neuropathy
metastasis
Joliet Oncology Hematology ( Site 0091)
 (8.0 away) Contact site
  • 69 views
  • 01 Aug, 2021
  • +228 other locations