Oak Brook, Illinois Clinical Trials

A listing of Oak Brook, Illinois clinical trials actively recruiting patient volunteers.

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Found 104 clinical trials
The Orchestra Study: An 18-month Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral UCB0599 in Study Participants With Early-stage Parkinson's Disease

The Orchestra Study (study number PD0053) is a clinical research study for people with early-stage Parkinson’s disease (<2 years). The aim of the study is to find out whether an investigational medication known as UCB0599 can slow the progression of Parkinson’s disease and whether it is efficacious and well tolerated (which means …

dopamine
motor symptoms
SPECT Scan
bradykinesia
dopamine transporter
Northwestern Memorial Healthcare - Office of Research
 (10.0 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • +22 other locations
LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active Non-Infectious Uveitis of the Posterior Segment of the Eye

This is a Phase III study to assess the efficacy and safety of DE-109 440 g every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month doublemasked, controlled period allows the …

Illinois Retina Associate
 (9.3 away) Contact site
  • 126 views
  • 01 Aug, 2021
  • +89 other locations
Study of Efficacy and Safety of Brolucizumab Versus Panretinal Photocoagulation Laser in Patients With Proliferative Diabetic Retinopathy

The purpose of this study is to evaluate the efficacy and safety of brolucizumab compared to panretinal photocoagulation laser (PRP) in patients with proliferative diabetic retinopathy (PDR). This evaluation will provide information that brolucizumab is non-inferior to PRP with respect to the change in best corrected visual acuity at Week …

Novartis Investigative Site
 (3.9 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +81 other locations
Safety Tolerability and Pharmacokinetics of Second Generation VIR-7831 Material in Non-hospitalized Participants With Mild to Moderate COVID-19

This is a phase 2 study in which subjects with coronavirus disease 2019 (COVID-19) will receive VIR-7831 (Sotrovimab) Generation 1 (Gen1) or VIR-7831 (Sotrovimab) Generation 2 (Gen2) and will be assessed for safety, tolerability, and pharmacokinetics.

Investigative Site
 (10.0 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +33 other locations
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

This study will evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics (PK) of obinutuzumab compared with tacrolimus in participants with primary membranous nephropathy (pMN).

Loyola University Med Center
 (6.8 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +77 other locations
Study of Sasanlimab (PF-06801591) in Combination With Bacillus Calmette-Guerin (BCG) in Participants With High-Risk Non-Muscle Invasive Bladder Cancer

CREST: Combination of sasanlimab and alternative BCG Regimens to Evaluate outcomes with Subcutaneous anti-PD-1 Treatment Phase 3 Design with 3 study Arms (A, B and C). Arms A and B consists of two study drugs, PF-06801591 plus BCG. Arm C consists of one study drug, BCG. The study is designed …

DuPage Medical Group Ambulatory Surgery Center
 (3.1 away) Contact site
  • 10 views
  • 01 Aug, 2021
  • +218 other locations
A Study to Assess the Effectiveness and Safety of Irinotecan Liposome Injection 5-fluorouracil/Leucovorin Plus Oxaliplatin in Patients Not Previously Treated for Metastatic Pancreatic Cancer Compared to Nab-paclitaxel+Gemcitabine Treatment

The purpose of this study is to look at the efficacy and safety of Irinotecan liposome injection in combination with other approved drugs used for cancer therapy, namely 5 fluorouracil/leucovorin (5FU/LV) plus oxaliplatin compared to nab-paclitaxel + gemcitabine treatment in improving the overall survival of patients not previously treated for …

Elmhurst Cancer Center Research
 (3.9 away) Contact site
  • 31 views
  • 01 Aug, 2021
  • +273 other locations
Fixed-Dose Trial in Early Parkinson's Disease (TemPo-1)

The purpose of this study is to evaluate the clinical efficacy, safety and pharmacokinetics (PK) of 2 fixed doses of tavapadon and placebo in participants with early Parkinson's Disease.

impulse control disorder
mao-b inhibitor
levodopa
dopamine
antiparkinsonian agents
Central DuPage Hospital - Movement Disorders Center
 (10.0 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +76 other locations
ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo …

Edward Hines VA Hospital (Site 074-012), 5000 S. 5th Ave.
 (6.7 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +38 other locations
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-programmed death ligand 1(PD-[L]1) agent …

renal function
transitional cell carcinoma
carcinoma
erdafitinib
vinflunine
Edward Hines Jr V A Hospital
 (6.8 away) Contact site
  • 271 views
  • 01 Aug, 2021
  • +592 other locations