Mattoon, Illinois Clinical Trials

A listing of Mattoon, Illinois clinical trials actively recruiting patient volunteers.

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Found 69 clinical trials
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

bevacizumab
rifampin
major surgery
vitamin d
tumor cells
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 65 views
  • 27 Jul, 2021
  • +978 other locations
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer the CompassHER2 RD Trial

This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted …

Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 0 views
  • 26 Jul, 2021
  • +762 other locations
Trying to Find the Correct Length of Treatment With Immune Checkpoint Therapy

This phase III trial compares survival in urothelial cancer patients who stop immune checkpoint inhibitor treatment after being treated for about a year to those patients who continue treatment with immune checkpoint inhibitors. Immunotherapy with monoclonal antibodies, such as avelumab, durvalumab, pembrolizumab, atezolizumab, and nivolumab, may help the body's immune …

Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 0 views
  • 30 Jul, 2021
  • +282 other locations
Additional Support Program Via Text Messaging and Telephone-Based Counseling for Breast Cancer Patients Receiving Hormonal Therapy

This phase III trial compares an additional support program (text message reminders and/or telephone-based counseling) with usual care in making sure breast cancer patients take their endocrine therapy medication as prescribed (medication adherence). Medication adherence is how well patients take the medication as prescribed by their doctors, and good medical …

Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 0 views
  • 27 Jul, 2021
  • +340 other locations
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery …

invasive carcinoma
beta human chorionic gonadotropin
mastectomy
diabetes
human chorionic gonadotropin
Carle Physician Group-Effingham
 (26.6 away) Contact site
  • 335 views
  • 28 Jul, 2021
  • +911 other locations
A Phase II/III Trial of Nivolumab Ipilimumab and GM-CSF in Patients With Advanced Melanoma

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may …

nitrosoureas
colony-stimulating factors
monoclonal antibody therapy
diabetes
mdx-ctla-4
Carle Physician Group-Effingham
 (26.6 away) Contact site
  • 46 views
  • 01 Aug, 2021
  • +430 other locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

transitional cell carcinoma
ovarian cancer
chordoma
human immunodeficiency virus
autoimmune disease
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 6047 views
  • 01 Aug, 2021
  • +814 other locations
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

gemcitabine
erlotinib
squamous cell carcinoma
adjuvant chemotherapy
tumor cells
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 1103 views
  • 01 Aug, 2021
  • +1138 other locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

HIV Infection
human immunodeficiency virus
mammogram
crizotinib
protease inhibitor
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 6087 views
  • 01 Aug, 2021
  • +1020 other locations
Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy

This randomized phase III trial studies how well olanzapine with or without fosaprepitant work in preventing chemotherapy induced nausea and vomiting in cancer patients receiving chemotherapy that causes vomiting. Olanzapine and fosaprepitant dimeglumine may help control nausea and vomiting in patients during chemotherapy. Olanzapine is usually given in combination with …

dexamethasone
diabetes
nausea
emetics
bilateral oophorectomy
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 109 views
  • 29 Jul, 2021
  • +603 other locations