Mattoon, Illinois Clinical Trials

A listing of Mattoon, Illinois clinical trials actively recruiting patient volunteers.

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Found 105 clinical trials
Testing the Addition of Ruxolitinib to the Usual Treatment (Tyrosine Kinase Inhibitors) for Chronic Myeloid Leukemia

This randomized phase II trial studies how well ruxolitinib phosphate, and bosutnib, dasatinib, or nilotinib, work in treating patients with chronic myeloid leukemia. Chronic myeloid leukemia cells produce a protein called BCR-ABL. The BCR-ABL protein helps chronic myeloid leukemia cells to grow and divide. Tyrosine kinase inhibitors, such as bosutinib, …

Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 38 views
  • 11 May, 2021
  • +441 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

rifampin
adjuvant therapy
tumor cells
major surgery
neutrophil count
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 65 views
  • 27 Jul, 2021
  • +978 other locations
A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy

This randomized, placebo-controlled phase III trial is evaluating the benefit of rucaparib and enzalutamide combination therapy versus enzalutamide alone for the treatment of men with prostate cancer that has spread to other places in the body (metastatic) and has become resistant to testosterone-deprivation therapy (castration-resistant). Enzalutamide helps fight prostate cancer …

Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +251 other locations
T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer the CompassHER2 RD Trial

This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted …

Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 0 views
  • 26 Jul, 2021
  • +762 other locations
Platinum Based Chemotherapy or Capecitabine in Treating Patients With Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Chemotherapy

This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the …

biomarker analysis
warfarin
epidermal growth factor receptor
oophorectomy
experimental drug
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 508 views
  • 24 Jan, 2021
  • +702 other locations
Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer

This randomized phase III trial studies how well hypofractionated radiation therapy works in preventing recurrence in patients with stage IIa-IIIa cancer who have undergone mastectomy. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells that remain after surgery …

carcinoma in situ
carcinoma
tumor cells
skin carcinoma
oophorectomy
Carle Physician Group-Effingham
 (26.6 away) Contact site
  • 335 views
  • 28 Jul, 2021
  • +911 other locations
A Phase II/III Trial of Nivolumab Ipilimumab and GM-CSF in Patients With Advanced Melanoma

This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may …

tumor cells
gilbert's syndrome
gm-csf
ipilimumab
diabetes
Carle Physician Group-Effingham
 (26.6 away) Contact site
  • 46 views
  • 01 Aug, 2021
  • +430 other locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

thyroiditis
thyroidectomy
trophoblastic disease
MRI
cholangiocarcinoma
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 6047 views
  • 01 Aug, 2021
  • +814 other locations
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes.

carcinoma
crizotinib
tumor cells
nivolumab
adenocarcinoma
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 1103 views
  • 01 Aug, 2021
  • +1138 other locations
Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy

This randomized phase III trial studies lymph node dissection and radiation therapy to see how well it works compared to radiation therapy alone in treating patients with breast cancer previously treated with chemotherapy and surgery. Lymph node dissection may remove cancer cells that have spread to nearby lymph nodes in …

carcinoma
tumor cells
estrogen
pertuzumab
skin carcinoma
Carle Physician Group-Mattoon/Charleston
 (0.3 away) Contact site
  • 476 views
  • 22 Jun, 2021
  • +741 other locations