Hines, Illinois Clinical Trials

A listing of Hines, Illinois clinical trials actively recruiting patient volunteers.

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Found 241 clinical trials
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A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

lung cancer
lung carcinoma
docetaxel
cancer chemotherapy
advanced lung cancer
Swedish Covenant Hospital
 (10.0 away) Contact site
  • 213 views
  • 28 Jul, 2021
  • +188 other locations
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in patients with metastatic castrate resistant prostate cancer (mCRPC). There will be nine cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, …

testosterone
bone metastases
olaparib
adenocarcinoma
androgen suppression
Call for Information (Investigational Site 0010)
 (7.7 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +13 other locations
Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adult Participants With COVID-19 (MK-4482-002)

This study aims to evaluate the safety, tolerability and efficacy of molnupiravir (MK-4482) compared to placebo. The primary hypothesis is that molnupiravir is superior to placebo as assessed by the percentage of participants who are hospitalized and/or die through Day 29

Loretto Hospital ( Site 1886)
 (4.5 away) Contact site
  • 1 views
  • 02 Aug, 2021
  • +143 other locations
Flexible-Dose Adjunctive Therapy Trial in Adults With Parkinson's Disease With Motor Fluctuations (TemPo-3)

The purpose of this study is to assess the effect of tavapadon on the change from baseline in total daily hours of "on" time without troublesome dyskinesia in L-Dopa-treated participants with Parkinson's Disease (PD) who are experiencing motor fluctuations.

carbidopa/levodopa
dyskinesia
amantadine
bradykinesia
levodopa
Rush University Medical Center
 (7.7 away) Contact site
  • 0 views
  • 31 Jul, 2021
  • +101 other locations
LUMINA Phase III Study Assessing the Efficacy and Safety of Intravitreal Injections of 440 ug DE-109 Sirolimus for the Treatment of Active Non-Infectious Uveitis of the Posterior Segment of the Eye

This is a Phase III study to assess the efficacy and safety of DE-109 440 g every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month doublemasked, controlled period allows the …

Illinois Retina Associate
 (2.5 away) Contact site
  • 126 views
  • 01 Aug, 2021
  • +89 other locations
Aging and Mixed Perturbation Training to Reduce Falls in Locomotion

The long-term objective of this research is to develop an efficacious training paradigm to enhance older adults' defense mechanisms against falls and possibility reduce healthcare cost. The Centers for Disease Control and Prevention estimates the direct medical cost for fall related injuries to be $30 billion annually. Slips and trips …

University of Illinois at Chicago
 (7.7 away) Contact site
  • 58 views
  • 20 Jul, 2021
  • 1 location
Study of Efficacy and Safety of Brolucizumab Versus Panretinal Photocoagulation Laser in Patients With Proliferative Diabetic Retinopathy

The purpose of this study is to evaluate the efficacy and safety of brolucizumab compared to panretinal photocoagulation laser (PRP) in patients with proliferative diabetic retinopathy (PDR). This evaluation will provide information that brolucizumab is non-inferior to PRP with respect to the change in best corrected visual acuity at Week …

Novartis Investigative Site
 (5.9 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +81 other locations
A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy

This study will evaluate the efficacy, safety, pharmacodynamics, and pharmacokinetics (PK) of obinutuzumab compared with tacrolimus in participants with primary membranous nephropathy (pMN).

Loyola University Med Center
 (1.2 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +77 other locations
Adalimumab vs. Conventional Immunosuppression for Uveitis Trial

Non-infectious intermediate, posterior, and panuveitides are chronic, potentially-blinding diseases. Vision-threatening cases require long-term therapy with oral corticosteroids and immunosuppression. Based upon preliminary data, adalimumab, a fully-human, anti-TNFmonoclonal antibody, now US FDA-approved for uveitis treatment, may be a superior corticosteroid-sparing agent than conventional immunosuppressive drugs. The ADVISE Trial is multicenter randomized, …

tumor necrosis factor
small molecule
tacrolimus
azathioprine
monoclonal antibodies
Rush University Medical Center
 (7.7 away) Contact site
  • 103 views
  • 02 Aug, 2021
  • +32 other locations
Study of Sasanlimab (PF-06801591) in Combination With Bacillus Calmette-Guerin (BCG) in Participants With High-Risk Non-Muscle Invasive Bladder Cancer

CREST: Combination of sasanlimab and alternative BCG Regimens to Evaluate outcomes with Subcutaneous anti-PD-1 Treatment Phase 3 Design with 3 study Arms (A, B and C). Arms A and B consists of two study drugs, PF-06801591 plus BCG. Arm C consists of one study drug, BCG. The study is designed …

John H. Stroger, Jr. Hospital of Cook County
 (7.4 away) Contact site
  • 10 views
  • 01 Aug, 2021
  • +218 other locations