Durate, Illinois Clinical Trials

A listing of Durate, Illinois clinical trials actively recruiting patient volunteers.

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Found 509 clinical trials
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The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

The objective of the RADIANCE II Pivotal study is to demonstrate the effectiveness and safety of the Paradise System in subjects with Stage 2 hypertension on 0-2 medications at the time of consent. Prior to randomization, subjects will be hypertensive in the absence of hypertension medication.

antihypertensive therapy
antihypertensive drugs
hypertension
renal angiogram
angiography
Northwestern University
 (6.7 away) Contact site
  • 877 views
  • 01 Aug, 2021
  • +82 other locations
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Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation (KRYSTAL-7)

This Phase 2 study evaluates the clinical activity and safety of MRTX849 in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS.

pembrolizumab
KRAS
USOR - Illinois Cancer Specialists - Niles
 (8.1 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • +40 other locations
featured
A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

squamous non-small cell lung cancer
lung carcinoma
cancer chemotherapy
advanced non-squamous non-small cell lung cancer
experimental drug
Swedish Covenant Hospital
 (3.9 away) Contact site
  • 199 views
  • 28 Jul, 2021
  • +188 other locations
Safety Tolerability and Evidence of Activity Study of UBX1325 in Patients With Diabetic Macular Edema (DME)

This study is intended to assess the safety, tolerability and evidence of pharmacodynamic activity of a single intravitreal (IVT) injection of UBX1325 in patients with diabetic macular edema (DME)

Northwestern University
 (9.8 away) Contact site
  • 0 views
  • 26 Jul, 2021
  • +31 other locations
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

The purpose of this study is to evaluate the objective response rate (complete response [CR]+ partial response [PR]) of the selected dose regimen in participants with metastatic or surgically unresectable urothelial cancers that harbor specific FGFR genomic alterations.

erdafitinib
renal function
adjuvant chemotherapy
dose regimen
measurable disease
Northwestern University Feinberg School of Medicine
 (6.7 away) Contact site
  • 40 views
  • 28 Jul, 2021
  • +152 other locations
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)

The purpose of this study is to assess the safety and efficacy of pembrolizumab (MK-3475) combination therapy in patients with metastatic castrate resistant prostate cancer (mCRPC). There will be nine cohorts in this study: Cohort A will receive pembrolizumab + olaparib, Cohort B will receive pembrolizumab + docetaxel + prednisone, …

testosterone
soft tissue disease
olaparib
solid tumour
docetaxel
Call for Information (Investigational Site 0010)
 (4.3 away) Contact site
  • 0 views
  • 25 Jul, 2021
  • +13 other locations
A Safety Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA

A randomized withdrawal study in which responders to open-label treatment with tofacitinib will be randomized in a 1:1 ratio to tofacitinib or placebo in a double-blind phase. In the double-blind phase "time to sJIA flare" will be evaluated as primary endpoint and subjects will be discontinued once they experience sJIA …

Ann & Robert H Lurie Children's Hospital of Chicago
 (7.1 away) Contact site
  • 134 views
  • 28 Jul, 2021
  • +100 other locations
Safety and Efficacy of Fibrin Sealant Grifols as an Adjunct to Haemostasis During Surgery in Paediatric Subjects

This is a prospective, randomized, active-controlled, single-blind, parallel group clinical trial to evaluate the safety and efficacy of FS Grifols as an adjunct to hemostasis during surgery in pediatric subjects. Pediatric subjects (<18 years of age) requiring an elective (non-emergent), open (non-laparoscopic), pelvic, abdominal, or thoracic (non-cardiac) surgical procedure, wherein …

Lurie Childrens Hospital of Chicago
 (6.7 away) Contact site
  • 0 views
  • 20 Jul, 2021
  • +44 other locations
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity will be assessed. ABBV-154 is …

stiffness
methotrexate
rheumatism
antirheumatics
Great Lakes Clinical Trials /ID# 228699
 (5.4 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +291 other locations
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix

This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters.

Northwestern University-Prentice Hospital
 (6.7 away) Contact site
  • 219 views
  • 26 Jul, 2021
  • +13 other locations